Preserving　the　vital　pulp　poses　significant　challenges　in　clinical　pulp　injury　repair.　Tricalcium　silicate　(C3S)based　cement　has　emerged　as　a　successful　pulp　capping　biomaterial.　However,　its　efficacy　in　inducing　pulp-　dentin　complex　regeneration　requires　enhancement,　and　handling　difficulties,　poor　anti-collapsible　ability　and　inadequate　self-setting　performance　remain　significant　obstacles,　restricting　its　broader　application　in　endodontics.　In　this　study,　a　multifunctional　SrCO3-doped　C3S　biocement　(C3S-Sr/F127-nHA)　reinforced　by　Pluronic　(R)　F127　thermoreversible　hydrogel　and　nano　hydroxyapatite　(nHA)　was　developed　to　overcome　the　limitations　of　C3S-based　cements.　The　thermoresponsive　characteristic　of　F127　conferred　the　C3S　pastes　smart　response　behavior,　allowing　for　optimal　operability　at　room　temperature　and　maintaining　excellent　anti-collapse　properties　at　body　temperature.　C3S-Sr/F127-nHA　exhibited　an　injectability　rate　of　up　to　93　%.　nHA　facilitated　the　hydration　kinetics　of　C3S,　resulting　in　reduced　setting　time　and　enhanced　compressive　strength.　Furthermore,　C3S-Sr/F127-nHA　demonstrated　excellent　apatite　mineralization　ability,　cytocompatibility,　and　potential　for　osteo/odontogenic　induction.　The　inclusion　of　Sr2+　ions　and　nHA　promoted　osteo/odontogenic　differentiation　of　stem　cells　isolated　from　human　exfoliated　deciduous　teeth　(SHED).　In　vivo　findings　indicated　that　C3S-Sr/F127nHA　could　stimulate　the　formation　of　a　homogeneous　dentin　bridge.　Consequently,　C3S-Sr/F127-nHA　is　a　promising　biocement　for　use　in　regenerative　endodontics.