This　study　characterizes　the　effect　on　different　engineering　demand　parameters　owing　to　lateral　spreading　caused　by　liquefaction.　1　g　large-scale　shaking　table　experiments　were　conducted　along　with　efficient　numerical　simulations　of　the　pilessupported　pier-superstructure　system　response　to　strong　earthquakes.　An　integrated　nonlinear　numerical　method　was　established　and　evaluated　with　the　results　of　the　shake　table　experiments,　and　the　seismic　response　characteristics　of　the　system　was　discussed　by　combining　the　experimental　and　numerical　results.　The　influence　of　the　initial　soil　hydraulic　conductivity　on　soil　liquefaction　was　evaluated　and　the　inertia　and　kinematic　effects　were　evaluated　employing　cross-correlation　analyses.　The　results　indicated　that　soil　softening　diminished　as　the　permeability　coefficient　increased,　and　consequently　the　lateral　displacements　of　soil　and　superstructure　decreased,　and　the　superstructure　acceleration　demand　increased.　Increased　permeability　coefficient　shifted　the　fragile　location　of　the　piles-supported　pier-superstructure　from　the　liquefiable　soil　bottom　to　the　pier　bottom.　Finally,　the　inertial　effect　increased　on　pile　curvature　near　pile　head　while　the　kinematic　effect　decreased　as　the　permeability　coefficient　increased.