Waste　fluidized　catalytic　cracking　(FCC)　catalysts　contain　strategic　metals　with　high　recycling　value,　and　effective　treatment　of　these　waste　catalysts　is　crucial　for　resource　recovery　and　environmental　protection.　In　this　study,　a　leaching　process　of　＂oxidation　treatment-alkali　roasting-wet　mill　leaching＂　was　proposed　for　the　extraction　of　tungsten　(W)　and　molybdenum　(Mo)　valuable　metals　from　spent　FCC　catalysts,　and　a　technological　pathway　suitable　for　industrial　production　was　explored　through　a　detailed　investigation　of　the　conversion　mechanism　and　process　optimization.　After　the　pretreatment　by　oxidation　and　roasting　at　600　degrees　C　for　4　h,　the　optimal　conditions　for　alkali　roasting　were　found　to　be　950　degrees　C　with　the　addition　of　three　times　the　theoretical　amount　of　alkali　(Na2CO3),　which　ensured　full　conversion　and　avoided　the　generation　of　impurities.　Through　one-factor　exploration　and　response　surface　optimization,　the　average　leaching　rate　for　W　and　Mo　reached　87.23%　and　99.50%,　respectively,　under　the　wet　mill　leaching　conditions　of　a　200-mesh　particle　size,　liquid-solid　ratio　of　2.79,　a　wet　milling　time　of　1.18　h,　a　pellet　ratio　of　6.44:1,　and　a　roasting　time　of　114.61　min.　It　was　observed　that　both　heating　leaching　and　wet　mill　leaching　could　achieve　full　extraction　with　a　relatively　small　liquid-solid　ratio,　thereby　minimizing　the　production　and　discharge　of　waste　liquid.　The　formation　of　nickel　tungstate　(NiWO4)　was　identified　as　the　main　factor　limiting　the　leaching　of　W,　and　it　was　found　that　increasing　the　oxygen　content　during　the　roasting　process　could　improve　the　leaching　efficiency.　This　study　provides　practical　guidance　and　a　scientific　basis　for　the　environmentally　friendly　and　resource-efficient　utilization　of　spent　FCC　catalysts.