A　multiphase　catalyst　(CoFe2O4@2D-V)　was　constructed　by　loading　CoFe2O4　on　two-dimensional　vermiculite　surface　via　hydrothermal　synthesis.　Levofloxacin　(LVX),　as　a　typical　antibiotic,　was　used　to　estimate　the　performance　of　CoFe2O4@2D-V　by　PMS　activation.　CoFe2O4@2D-V　exhibited　an　excellent　adsorption　and　degradation　performance　for　LVX.　Experimental　results　showed　an　88.6　%　of　LVX　removal　efficiency　and　0.048　min−1　of　LVX　removal　rate　obtained　in　CoFe2O4@2D-V/PMS　system　under　the　conditions　of　a　15　%　CoFe2O4　mass　ratio　(15　%-CoFe2O4@2D-V),　initial　pH　6.89,　[LVX]0　10　mg/L,　[Catalyst]0　0.3　g/L,　and　[PMS]0　0.35　mM.　Adsorption　removal　accounted　for　35.1　%　of　LVX　removal.　The　prominent　roles　of　LVX　degradation　were　radical　way　mainly　contributed　by　•SO4-　and　non-radical　way　achieved　by　1O2.　The　redox　cycle　between　Co(III)/Co(II)　and　Fe(III)/Fe(II)　played　a　crucial　role　in　activating　PMS　to　generate　reactive　oxygen　species　(ROS).　In　addition,　15　%-CoFe2O4@2D-V　had　less　ion　leakage,　high　reusability,　and　excellent　adaptability.　Four　degradation　pathways　of　LVX　in　15　%-CoFe2O4@2D-V/PMS　system　were　proposed.　ECOSAR　evaluation　show　that　LVX　and　its　degradation　intermediates　pose　minimal　harm　to　the　ecosystem.　15　%-CoFe2O4@2D-V　is　an　environmentally　friendly　and　efficient　catalyst　for　LVX　removal　by　PMS　activation,　which　may　provide　a　new　idea　for　developing　loaded　catalysts　for　antibiotics　removal　through　adsorption　and　catalysis.　©　2024　Elsevier　Ltd