The　seismic　dynamic　response　of　pile　foundation　in　inclined　liquefaction　site　is　an　important　issue　in　the　field　of　geotechni‑　cal　seismic　engineering.　Based　on　the　shaking　table　model　test　carried　out　by　our　research　group　and　the　OpenSees　software　plat‑　form，a　two-dimensional　integrated　numerical　model　of　inclined　liquefied　soil-pile　group-structure　interaction　is　established　in　this　paper.　The　nonlinearity　of　pile-soil　contact　and　the　shear　localization　of　soil　layer　are　considered　in　the　model.　The　rationality　and　ef‑　fectiveness　of　the　numerical　simulation　method　are　verified　by　comparing　with　the　shaking　table　test　results.　On　this　basis，a　typical　inclined　liquefied　site-pile　group-structure　interaction　finite　element　model　is　established　to　discuss　the　influence　of　different　overly‑　ing　crust　on　the　seismic　response　of　site　and　structure　system.　The　calculation　results　show　that　with　the　increase　of　the　thickness　of　overlying　crust，the　pore　pressure　ratio　in　the　saturated　sand　decreases，the　horizontal　residual　displacement　of　soil　decreases，and　the　displacement　of　pile　body　and　the　pile　curvature　decrease.　The　effect　of　the　strength　of　overlying　crust　on　the　dynamic　response　of　pile　foundation　is　more　obvious.　The　increase　of　the　thickness　of　overlying　crust　can　reduce　the　liquefaction　degree　of　sand　and　improve　the　mechanical　performance　of　pile　foundation.　©　2024　Nanjing　University　of　Aeronautics　an　Astronautics.　All　rights　reserved.