It　is　important　to　assess　the　temporal　evolution　of　environmental　impacts　arising　from　municipal　solid　waste　(MSW)　under　different　policies,　especially　in　China.　However,　most　previous　research　has　primarily　focused　on　the　effects　of　policies　at　the　system　management　level,　neglecting　their　influence　on　technical-level　implementation,　which　compromises　the　accuracy　of　policy　effect　simulations.　This　study　developed　a　comprehensive　simulation　model　that　integrates　a　life　cycle　assessment　(LCA)　and　a　dynamic　simulation　model　of　a　complex　system　to　enhance　the　accuracy　of　environmental　impact　simulations　of　the　MSW　management　system　in　Guangzhou.　The　model　considers　how　different　measures　affect　changes　in　the　physical　composition　of　MSW　at　the　technical　level　and　their　subsequent　impact　on　MSW　generation　at　the　system　level.　The　study　employed　five　scenarios　to　simulate　the　impacts　of　different　strategies　on　MSW　generation　levels　and　environmental　consequences　of　MSW　treatment　systems,　encompassing　the　entire　process　of　generation,　collection,　and　disposal.　LCA　results　simulate　a　24.14%　reduction　in　the　unit　environmental　impact　of　incineration　technology　due　to　MSW　classification,　which　alters　the　material　composition,　decreases　water　content,　and　enhances　the　caloric　value.　The　comprehensive　simulation　model＇s　results　illustrate　that　implementing　measures　such　as　MSW　charging,　economic　control,　and　population　control　can　effectively　reduce　overall　MSW　by　31.35%.　In　terms　of　environmental　impact,　Guangzhou　reached　its　peak　in　2018　but　experienced　a　subsequent　decline　due　to　the　continuous　implementation　of　MSW　classification　policies.　Among　the　various　strategies　considered,　the　scenario　focusing　on　technological　improvement　exhibited　the　most　significant　reduction　in　overall　environmental　impact　by　enhancing　power　generation　efficiency　and　minimizing　pollution　emissions,　followed　by　metering　and　charging　policies　utilizing　economic　levers.　Finally,　recommendations　on　the　coupling　effect　of　policies,　greenhouse　gas　emission　reduction,　and　incineration　residue　recycling　are　proposed.　The　comprehensive　simulation　model　can　provide　scientific　theoretical　support　to　build　a　sustainable　MSW　treatment　system　for　Guangzhou　and　other　cities　worldwide.