Modulating　the　Fenton-like　activity　of　metal-carbon　catalysts　relies　highly　on　the　regulation　of　the　active　sites,　but　the　detailed　correlation　mechanism　between　active　metal　center　and　oxidation　pathway　is　still　challenging　but　highly　desirable.　Herein,　metal-organic　framework　(MOF)　derived　carbon-coated　Co/MnO　composites　(Co/　MnO@C)　with　varying　Co/Mn　proportion　were　constructed　for　activating　peroxymonosulfate　(PMS)　to　efficiently　degrade　tetracycline　(TC).　Theoretical　and　experimental　analyses　testified　that　the　proper　proportion　of　Co/Mn　in　Co/MnO@C　not　only　regulate　PMS　adsorption　and　improve　the　charge　density,　but　also　facilitate　interfacial　charge　deliver　to　cleave　O-O　bonds　of　adsorbed　PMS　molecules,　which　was　favorable　to　strengthen　the　singlet　oxygen　(1O2)　and　electron　transfer　mediated　nonradical　oxidation　process,　and　further　to　achieve　almost　90　%　nonradical　oxidation.　When　ratioCo/Mn　in　precursor　became　1.35,　Co/MnO@C1.35　exhibited　the　best　degradation　performance　with　the　rate　constant　of　1.015　min-1　and　degradation　rate　of　93　%　within　15　min.　Furthermore,　Co/MnO@C1.35/PMS/TC　system　exhibited　wide　applicability　and　high　long-term　operation　stability,　the　biological　toxicity　of　Co/MnO@C1.35/PMS/TC　system　was　significantly　attenuated　by　wheat　growth　experiments　and　toxicity　assessment　analysis.　This　work　provides　valuable　insights　into　precise　regulation　of　active　sites　of　metal-carbon　confinement　catalysts,　and　in　turn　modulation　of　reaction　mechanism　for　Fenton-like　decontamination.