MXene　are　a　new　class　of　materials　that　have　gained　great　attention　due　to　their　potential　as　multifunctional　materials　for　a　variety　of　advanced　technological　applications.　The　density　functional　theory　was　utilized　to　investigate　the　effect　of　layer-dependent　physical　properties　of　V-based　MXenes.　Therefore,　first　principle　calculation　was　conducted　to　examine　the　effect　of　atomic　layers　on　the　structure　stability,　electronic,　optical　and　thermodynamic　properties　of　investigated　compounds.　The　findings　indicate　that　the　atomic　layers　significantly　affect　structural　stability.　The　electronic　properties　reveal　that　V-based　MXenes　are　metallic　in　nature,　as　increase　the　atomic　layers　the　total　density　of　states　at　fermi　level　increases.　The　optical　properties　of　different　atomic　layers　were　calculated,　and　the　results　showed　that　increasing　the　number　of　layers　leads　to　an　increase　in　optical　properties.　Furthermore,　the　thermodynamic　properties　of　V-based　MXenes　such　as　bulk　modulus,　Debye　temperature,　heat　capacity,　entropy　and　Gibbs　free　energy　with　different　atomic　layers　were　calculated　through　Gibbs2　code.　An　increase　in　the　number　of　atomic　layers　leads　to　significant　changes　in　the　physical　properties,　enhancing　their　suitability　for　optoelectronic　and　energy　storage　applications.　The　study　of　V-based　MXenes　in　this　work　offers　valuable　insights　for　the　advancement　of　cutting-edge　technologies.　©　2025　Elsevier　Ltd