In　this　paper,　the　soil　and　structure　as　an　integrate　system,　using　plan　soil-structure　interaction　model,　a　practical　seismic　response　analysis　method　considering　soil-structure　interaction　of　high-rise　buildings　is　proposed.　In　this　method,　the　plan　frame-shear　wall　(tube)　cooperative　work　model　is　used　in　the　upper　structure.　A　soil　mass　with　height　H　and　width　B,　and　thickness　t　is　used　to　simulate　the　foundation　soils.　About　the　constitutive　model　of　soil,　Duncan-Chang　model　is　used　in　static　analysis,　the　equivalent　linearization　model　is　used　in　dynamic　analysis.　The　flexible,　rigid　and　pile　foundation　are　simulated　by　beam　element,　rigid　block　or　plate　element,　respectively.　The　influence　of　soil-structure　interaction　on　seismic　response　of　high-rise　buildings　and　the　application　of　this　method　are　illustrated　by　two　examples　of　high-rise　buildings　with　deep　foundation　soil.