Based　on　the　assumption　that　the　variation　rate　of　average　thickness　of　the　deposition　layer　is　proportional　to　the　difference　in　the　masses　of　solutes　brought　to　the　membrane　surface　by　the　bulk　fluid　flow　and　the　solutes　removed　from　the　membrane　surface　by　the　shear　rate　of　the　tangential　flow,　a　simple　convective　model　for　unsteady-state　transient　flux　prediction　in　cross-flow　microfiltration　has　been　developed.　The　correlation　coefficient　between　the　model　parameter　B　and　operating　conditions　was　used　to　analyze　the　influence　of　operating　conditions　on　the　model　parameter　B.　The　experiment　was　carried　out　with　yeast　suspension　under　different　operating　conditions　in　0.1　μm　PVDF　hollow-fiber　module　with　0.3　m2　filtration　area,　and　the　model　was　validated　with　experimental　data.　The　analytical　result　showed　that　the　model　parameter　B　was　independent　of　operating　conditions　when　taking　the　significance　level　α　=　0.05,　and　when　the　mean　value　of　the　model　parameter　B　under　different　operating　conditions　as　a　constant　was　put　into　the　model,　the　result　showed　that　the　model　prediction　is　in　accordance　with　the　experimental　observation.　©　2009　Elsevier　B.V.　All　rights　reserved.