An　experimental　investigation　of　performance　and　a　two-phase　flow　in　a　liquid　fed　direct　methanol　fuel　cell　with　a　three-channel　serpentine　anodic　flow　field　has　been　conducted.　Carbon　dioxide　bubbles　and　methanol　solution　in　the　anode　flow　bed　of　liquid　fed　direct　methanol　fuel　cells　forms　a　two-phase　flow　system.　The　characteristics　of　the　two-phase　flow　are　influenced　by　the　design,　operating　condition　and　operating　angle　of　the　flow　channel,　and　impact　the　performance　of　fuel　cells　at　the　same　time.　A　three-channel　serpentine　flow　field　was　designed.　The　visualization　experiments　of　a　liquid　fed　direct　methanol　fuel　cell　were　performed　to　investigate　relation　between　current　density　and　the　two-phase　flow　in　a　three-channel　serpentine　anodic　flow　field.　The　two-phase　flow　and　performance　of　fuel　cells　at　different　angles　were　studied.　The　experimental　results　indicated　that　fuel　cell　showed　good　performance　in　different　orientations.