In　major　city,　buried　pipelines　are　more　and　more　important　in　our　life.　Its　types　and　layouts　are　very　various,　and　its　surroundings　are　very　complicated.　Now,　it　has　been　a　research　hot　topic　in　world　earthquake　engineering　field　that　how　to　ensure　its　safety　when　extreme　earthquake　occurred　in　the　future.　So,　in　this　paper,　based　on　the　ABAQUS　software,　seismic　responses　of　the　soil-pipeline　system　under　different　cases　are　studied,　then,　the　effects　of　some　factors　on　seismic　response　of　buried　pipeline　are　analyzed,　including　the　vibration　direction　of　earthquake,　embedded　depth　of　pipe,　pipe　diameter,　wall　thickness　of　pipe,　and　tube　spacing.　Finally,　some　effect　laws　are　proposed.