A　novel　waveguided　metallic　photonic　crystal　based　label-free　biosensor　which　couples　the　particle　plasmon　resonance　and　the　waveguide　resonance　mode　has　been　developed.　It　enhances　the　sensitivity　of　the　particle　Plasmon　resonance　by　several　times.　And　the　sensor　chip　was　further　modified　with　protein　A.　Three　different　concentrations　of　mouse　IgG　were　detected.　The　results　indicate　that　the　response　has　correlation　with　the　concentrations.　And　the　sensor　chips　can　be　reused　many　times　by　cleaning　with　the　plasma　cleaner.　The　biosensor　has　advantages　of　low　cost,　simple　design　and　simple　operation.　©　2013　IEEE.