The　outbreak　of　Hand-Foot-Mouth　Disease　(HFMD)　has　brought　a　serious　threat　to　people＇s　health.　There　is　no　research　considering　both　the　natural　and　social　environment　to　study　the　outbreak　and　propagation　of　HFMD　quantitatively　by　now.　In　this　study,　we　acquired　environmental　impact　factors　of　HFMD　using　remote　sensing　and　GIS.　Then　we　analyzed　the　relationship　between　density　of　HFMD　cases　and　environmental　impact　factors　for　year　2009　in　Shenzhen.　It　was　found　that　density　of　HFMD　cases　was　significantly　associated　with　population　density,　hospital　density,　road　density,　annual　average　of　aerosol　optical　depth,　and　annual　average　of　normalized　difference　vegetation　index.　A　linear　regression　model　was　constructed　with　the　R2　value　of　0.677　using　environmental　impact　factors,　and　both　hospital　density　and　annual　average　of　aerosol　optical　depth　were　included　in　the　model.　©　2012　IEEE.