A　series　of　new　fluoro　S-nitrosothiols　is　reported　as　potential　nitric　oxide　(NO)　donors.　A　three-step　synthesis　and　the　NO　releasing　kinetic　profiles　of　these　species　are　presented.　The　stoichiometric　release　of　NO,　with　the　clean　formation　of　corresponding　disulfides,　confirms　that　these　new　species　can　facilitate　their　application　as　NO　donors　for　various　applications　including　creating　novel　antimicrobial　and　thromboresistant　fluoropolymer-based　medical　devices.