This　study　explored　the　flap-protective　effects　of　high　concentrations　of　hydrogen　(HCH)　inhalation　in　a　rat　flap　ischemia/reperfusion　(I/R)　injury　model　and　the　potential　mechanism　of　necroptosis.　Forty-five　male　Sprague-Dawley　rats　were　randomly　divided　into　three　groups:　SH,　IR　and　HCH　groups.　After　undergoing　3　h　of　I/R　management,　the　surgery　groups　were　treated　with　ambient　air　(SH　and　IR)　and　high　concentrations　of　hydrogen　(HCH).　On　the　third　postoperative　day,　blood　perfusion　in　the　flap　was　measured　using　Laser　Doppler　flowmeters.　RIP1,　RIP3,　MLKL,　PGAM5　and　Drp1　were　examined　by　immunological　detection　and　RT-qPCR.　Compared　to　the　IR　group,　larger　areas　of　the　skin　flaps　from　the　SH　and　HCH　groups　survived　and　displayed　more　blood　perfusion.　RIP1,　RIP3,　MLKL,　PGAM5　and　Drp1　were　expressed　at　high　levels　in　the　IR　group,　and　their　expression　was　significantly　decreased　in　the　HCH　group.　In　the　SH　and　HCH　groups,　the　necrotic　factors　measured　here　showed　similar　expression　levels,　which　were　significantly　lower　than　the　levels　in　the　IR　group,　indicating　that　HCH-mediated　protective　effects　on　rat　skin　I/R　necrosis　may　be　associated　with　the　necrotic　pathway.