Compared　to　regular　octahedron　and　tetrahedron　Pt-alloy　nanoparticles,　concave　hexahedron　CuPt　alloy　nanoparticles　have　larger　surface　area.　Moreover,　the　incorporation　of　Cu　atoms　allows　it　exhibits　higher　stability　under　harsh　environment.　In　this　paper,　unique　concave　hexahedron　CuPt　alloy　nanoparticles　were　prepared　through　a　facial　hydrothermal　method.　The　structures　were　characterized　by　scanning　electron　microscope　(SEM),　transmission　electron　microscope　(TEM),　scanning　transmission　electron　microscopy-high　angle　annular　dark　field　(STEM-HAADF),　X-ray　diffraction　(XRD)　and　X-ray　photoelectron　spectroscopy　(XPS).　The　results　show　that　the　sample　is　concave　hexahedron　uniform　particles　with　size　of　about　30　nm.　The　as-prepared　CuPt/C　catalyst　exhibits　12　times　catalytic　activity　than　commercial　Pt/C　towards　methanol　oxidation　and　presents　excellent　poison　resistance　which　can　prove　it　to　be　a　potential　anode　catalyst　for　fuel　cell.　©　2018,　Editorial　Office　of　Materials　Science　and　Engineering　of　Powder　Metallurgy.　All　right　reserved.