Renal　sympathetic　denervation　is　regarded　as　a　new　effective　method　in　the　treatment　of　resistant　hypertension,　but　in　the　therapeutic　temperature　and　complications,　it　has　some　controversy.　The　aim　of　this　study　was　to　calculate　the　multi-physical　field　for　radiofrequency　ablation　and　verify　its　feasibility　and　effectiveness　with　ex　vivo　experiments.　The　temperature　distribution　and　flow　field　in　the　renal　artery　were　analyzed　by　finite　element　method　and　verified　by　ex　vivo　experiments　with　an　equivalent　model.　After　ablating　in　simulation,　the　center　temperature　of　the　renal　artery　reached　the　therapeutic　target　which　is　43　degrees　C　(about　48　degrees　C).　When　increasing　the　time　or　changing　the　velocity,　variations　in　the　temperature　ranged　within　2　degrees　C.　In　the　ex　vivo　experiments,　the　highest　temperature　under　different　conditions　increased　from　4.12　degrees　C　to　9.61　degrees　C.　Within　the　range　of　the　normal　velocity,　that　is,　8W　power　output,　the　therapeutic　purpose　(Delta　T　＞=　6　degrees　C)　was　achieved　and　effect　on　the　blood　and　peripheral　tissues　was　less.　The　temperature　field　has　influences　on　the　choices　of　treatment　parameters　with　different　degrees.　The　energy　output　is　the　most　influential　factor,　while　ablation　time　and　flow　velocity　have　less　effects　on　the　temperature　field.　This　study　preliminarily　verified　the　safety　and　effectiveness　of　the　renal　sympathetic　denervation.