The　floor　systems　consisting　of　beams　and　slabs　are　the　main　elements　of　frame　strudctures　to　resist　progressive　collapse.　To　assess　the　influences　of　various　parameters　on　the　progressive　collapse　resistance　of　reinforced　concrete　(RC)　frame　structures,　8　scaled-down　specimens　of　one-way　RC　beam-slab　substructures　with　different　sectional　dimensions　and　reinforcement　ratios　were　designed　in　accordance　with　the　Code　for　Design　of　Concrete　Structures　(GB　50010-2010).　Furthermore,　the　vertical　loading　experiments　were　preformed　to　study　the　material　deformation/damage　and　the　progressive　collapse　resistance　of　the　specimens　after　the　failure　of　the　middle　column.　The　experimental　results　indicated　that　the　collapse-resisting　capacity　of　the　beam-slab　specimens　was　significantly　higher　than　that　of　the　beam　specimens　with　identieal　dimensions　of　the　beam　section.　The　collapse-resisting　capacity　of　specimens　under　the　beam　mechanism　was　determined　by　the　cross-sectional　dimensions　and　reinforcement　area,　while　the　capacity　under　the　catenary　mechanism　was　only　affected　by　the　reinforcement　area.　The　collapse-resisting　capacity　under　the　beam　mechanism　was　greatly　improved　by　increasing　the　width　and　thickness　of　slabs,　the　reinforcement　in　slabs,　and　the　height　of　beam.　However,　the　contribution　of　slab　width　was　not　significant　when　it　exceeded　a　certain　value.　Only　slab　width　and　reinforcement　ratio　may　significantly　affected　the　collapse-resisting　capacity　under　the　catenary　mechanism.　Seismic　reinforcement　in　beams　had　little　influence　on　the　carrying　capacity　of　the　scaled-down　specimens　under　the　two　mechanisms.　©　2016,　Editorial　Office　of　China　Civil　Engineering　Journal.　All　right　reserved.