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Author:

Li, Boye (Li, Boye.) | Shen, Sisi (Shen, Sisi.) | Zhang, Wenmei (Zhang, Wenmei.) | Qi, Tingjuan (Qi, Tingjuan.) | Hu, Qin (Hu, Qin.) | Cheng, Yuan (Cheng, Yuan.)

Indexed by:

Scopus SCIE

Abstract:

Background: Emerging evidence suggests that long non-coding RNAs (lncRNAs) can be used as potential biomarkers for a wide range of cancers. Herein, the prognostic value of lncRNA taurine upregulated gene (TUG1) was analyzed using meta-analysis in different kinds of cancers. Methods: Databases including Cochrane Library, PubMed, and Chinese National Knowledge Infrastructure were searched for epidemiological studies up to March 2018. Hazard ratio (HR) and its 95% confidence interval (CI) were calculated to probe the relationship between TUG1 expression and overall survival of various cancer patients. The odds ratio (OR) was calculated to measure the strength of the association between TUG1 expression and gender, distant metastasis, vascular invasion, lymph node metastasis, and vascular invasion using Rev Man 5.3 and STATA12.0 software. Results: A total of 24 studies involving 2,117 cancer cases were enrolled. Our results demonstrated that a high expression of TUG1 was not associated with patient gender (odds ratio [OR] = 0.95, 95% confidence interval [CI] = 0.72 -1.25, p = 0.71), but was a significant risk factor for distant metastasis (OR = 4.18, 95% CI = 1.89 -9.27, p = 0.0004), vascular invasion (OR = 12.19, 95% CI = 2.71 -54.89, p = 0.001) and lymph node metastasis (OR = 1.80, 95% CI = 1.16 -2.80, p = 0.009). Furthermore, hazard ratio (HR) analysis suggested that TUG1 expression was not significantly correlated with overall survival (HR: 0.15, 95% CI: -0.21 to 0.51, p = 0.406), except for patients with bladder cancer (HR: 1.01, 95% CI: 0.25 -1.78, p = 0.01). In the subgroup analysis, cancer type, sample size, and TUG1 expression levels affected the association between TUG1 expression and cancer prognosis. No evidence of publication bias was detected. Conclusions: Our meta-analysis revealed that a high expression of the lncRNA TUG1 was significantly associated with poor prognosis in patients with various cancers. Therefore, lncRNA TUG1 could be considered as a potential prognostic factor in different cancer types.

Keyword:

TUG1 meta-analysis prognosis carcinoma long non-coding RNA

Author Community:

  • [ 1 ] [Li, Boye]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China
  • [ 2 ] [Shen, Sisi]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China
  • [ 3 ] [Zhang, Wenmei]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China
  • [ 4 ] [Qi, Tingjuan]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China
  • [ 5 ] [Hu, Qin]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China
  • [ 6 ] [Cheng, Yuan]Peking Univ, Hosp 1, Dept Resp & Crit Care Med, Xishiku St 7, Beijing, Peoples R China

Reprint Author's Address:

  • [Hu, Qin]Beijing Univ Technol, Coll Life Sci & Bioengn, Pingleyuan 100, Beijing, Peoples R China;;[Cheng, Yuan]Peking Univ, Hosp 1, Dept Resp & Crit Care Med, Xishiku St 7, Beijing, Peoples R China

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Source :

CLINICAL LABORATORY

ISSN: 1433-6510

Year: 2018

Issue: 11-12

Volume: 64

Page: 1799-1808

0 . 7 0 0

JCR@2022

ESI Discipline: CLINICAL MEDICINE;

ESI HC Threshold:167

JCR Journal Grade:4

Cited Count:

WoS CC Cited Count: 5

SCOPUS Cited Count: 8

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 7

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