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Author:

Huang, Xin (Huang, Xin.) | Li, Zhipeng (Li, Zhipeng.) | Cao, Tingting (Cao, Tingting.) | Cai, Qian (Cai, Qian.) | Zeng, Chengchu (Zeng, Chengchu.) (Scholars:曾程初) | Fu, Hua (Fu, Hua.) | Hu, Liming (Hu, Liming.) (Scholars:胡利明)

Indexed by:

EI Scopus SCIE

Abstract:

A methylene blue-based near-infrared fluorescent probe was designed for the selective determination of hypochlorite (ClO-), over other reactive oxygen species or interfering agents. Acetylated methylene blue was synthesized by introducing the acetyl group into the methylene blue framework, which can specifically recognize exogenous and endogenous ClO-. The acetylated methylene blue fluorescent probe was characterized by H-1 NMR, C-13 NMR and HRMS. The response process and possible mechanism were studied using products of the probe. The emission response of the probe to ClO- presented good linear relationship in the 0-60 M concentration range, with the detection limit of 0.1 M (measured at 660 nm and 690 nm). The absorption and emission wavelengths of acetylated methylene blue are both in the near-infrared region; in addition, the probe itself and the degradation products were well-dissolved in water and have almost no toxicity. The probe was used for intracellular ClO- imaging and showed a large fluorescence enhancement (about 200-fold increase).

Keyword:

Author Community:

  • [ 1 ] [Huang, Xin]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 2 ] [Li, Zhipeng]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 3 ] [Cao, Tingting]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 4 ] [Cai, Qian]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 5 ] [Zeng, Chengchu]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 6 ] [Hu, Liming]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 7 ] [Fu, Hua]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
  • [ 8 ] [Hu, Liming]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

Reprint Author's Address:

  • 胡利明

    [Hu, Liming]Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China;;[Hu, Liming]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

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RSC ADVANCES

ISSN: 2046-2069

Year: 2018

Issue: 26

Volume: 8

Page: 14603-14608

3 . 9 0 0

JCR@2022

ESI Discipline: CHEMISTRY;

ESI HC Threshold:192

Cited Count:

WoS CC Cited Count: 20

SCOPUS Cited Count: 17

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

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