Synthesis of amphiphilic dextran-poly(lactide) copolymer and their nanoparticles as doxorubicin delivery systems - Details

Author：

Sun, J.-H. (Sun, J.-H..) (Scholars：孙继红) | Wen, L.-L. (Wen, L.-L..) | Wu, Y. (Wu, Y..) | Wang, H. (Wang, H..) | Li, Y.-W. (Li, Y.-W..)

Indexed by：

Scopus PKU CSCD

Abstract：

Novel　biodegradable　amphiphilic　copolymer　nanoparticles　based　on　dextran　and　poly(lactide)　have　been　prepared.　To　estimate　the　feasibility　as　drug　carriers,　an　anti-tumor　model　drug　doxorubicin　(DOX)　was　successfully　incorporated　into　polymeric　nanoparticles　by　double　emulsion　(DE)　and　nanoprecipitation　(NP)　methods.　The　DOX-loaded　nanoparticles　were　confirmed　by　dynamic　light　scattering　(DLS),　transmission　electron　microscopy　(TEM)　and　ultraviolet　(UV)　absorption　spectrometry.　The　DOX-loaded　nanoparticle　size,　size　distribution　and　encapsulation　efficiency　(EE)　were　influenced　by　the　feed　weight　ratio　of　the　copolymer　to　DOX.　In　addition,　in　vitro　release　experiments　exhibited　the　release　behavior　was　affected　by　pH　of　release　media.　The　DOX-loaded　nanoparticles　release　slower　in　pH　7.4　than　in　pH　5.0　buffer.　The　dextran-co-PLA　polymeric　nanoparticles　can　be　useful　as　drug　carriers　for　anti-tumor　drug　delivery.

Keyword：

Dextran; Grafted copolymer; In vitro release; L-lactide; Nanoparticles

Author Community：

[ 1 ] [Sun, J.-H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 2 ] [Wen, L.-L.]College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
[ 3 ] [Wu, Y.]National Center for Nanoscience and Technology, Chinese Academy of Science, Beijing 100190, China
[ 4 ] [Wang, H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 5 ] [Li, Y.-W.]College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

Reprint Author's Address：

孙继红
[Sun, J.-H.]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China

Email：

jhsun@bjut.edu.cn

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Source ：

Journal of Beijing University of Technology

ISSN： 0254-0037

Year： 2013

Issue： 8

Volume： 39

Page： 1269-1274

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 10

Affiliated Colleges：

化学与生命科学学院本学院/部未明确归属的数据

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