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学者姓名：吴水才
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Abstract ：
Accurate segmentation of the liver and liver tumors is crucial for clinical diagnosis and treatment. However, the task poses significant challenges due to the complex morphology of tumors, indistinct features of small targets, and the similarity in grayscale values between the liver and surrounding organs. To address these issues, this paper proposes an enhanced 3D UNet architecture, named ELANRes-MSCA-UNet. By incorporating a structural re-parameterized residual module (ELANRes) and a multi-scale convolutional attention module (MSCA), the network significantly improves feature extraction and boundary optimization, particularly excelling in segmenting small targets. Additionally, a two-stage strategy is employed, where the liver region is segmented first, followed by the fine-grained segmentation of tumors, effectively reducing false positive rates. Experiments conducted on the LiTS2017 dataset demonstrate that the ELANRes-MSCA-UNet achieved Dice scores of 97.2% and 72.9% for liver and tumor segmentation tasks, respectively, significantly outperforming other state-of-the-art methods. These results validate the accuracy and robustness of the proposed method in medical image segmentation and highlight its potential for clinical applications.
Keyword ：
multi-feature extraction multi-feature extraction structural re-parameterization structural re-parameterization liver and tumor segmentation liver and tumor segmentation multi-scale convolutional attention multi-scale convolutional attention 3D UNet 3D UNet
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| GB/T 7714 | Song, Ziwei , Wu, Weiwei , Wu, Shuicai . Multi-Scale Convolutional Attention and Structural Re-Parameterized Residual-Based 3D U-Net for Liver and Liver Tumor Segmentation from CT [J]. | SENSORS , 2025 , 25 (6) . |
| MLA | Song, Ziwei 等. "Multi-Scale Convolutional Attention and Structural Re-Parameterized Residual-Based 3D U-Net for Liver and Liver Tumor Segmentation from CT" . | SENSORS 25 . 6 (2025) . |
| APA | Song, Ziwei , Wu, Weiwei , Wu, Shuicai . Multi-Scale Convolutional Attention and Structural Re-Parameterized Residual-Based 3D U-Net for Liver and Liver Tumor Segmentation from CT . | SENSORS , 2025 , 25 (6) . |
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Abstract ：
Objectives: Given the escalating global prevalence of age-related cognitive impairments, identifying modifiable factors is crucial for developing targeted interventions. Methods: After excluding participants with dementia and substantial missing data, 453,950 individuals from UK Biobank (UKB) were included. Cognitive decline was assessed across four cognitive domains. The top 10% exhibiting the greatest decline were categorized as the "Cognitively At-Risk Population". Eighty-three potential factors from three categories were analyzed. Univariate and multivariate Cox proportional hazards models were employed to assess the independent and joint effects of these factors on cognitive decline. Population Attributable Fractions (PAFs) were calculated to estimate the potential impact of eliminating each risk category. Results: Our findings revealed a significant impact of unfavorable medical and psychiatric histories on processing speed and visual episodic memory decline (Hazard Ratio (HR) = 1.34, 95% CI: 1.20-1.51, p = 6.06 x 10(-)7; HR = 1.50, 95% CI: 1.22-1.86, p = 1.62 x 10(-)4, respectively). Furthermore, PAF analysis indicated that physiological and biochemical markers were the most critical risk category for preventing processing speed decline (PAF = 7.03%), while social and behavioral factors exerted the greatest influence on preventing visual episodic memory decline (PAF = 9.68%). Higher education, socioeconomic status, and handgrip strength emerged as protective factors, whereas high body mass index (BMI), hypertension, and depression were detrimental. Conclusions: By identifying this high-risk group and quantifying the impact of modifiable factors, this study provides valuable insights for developing targeted interventions to delay cognitive decline and improve public health outcomes in middle-aged and older adults.
Keyword ：
cognitive decline cognitive decline cognitive reserve cognitive reserve modifiable factors modifiable factors UK Biobank UK Biobank cognitive vulnerability cognitive vulnerability neurodegenerative diseases neurodegenerative diseases
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| GB/T 7714 | Ma, Xiangge , Gao, Hongjian , Wu, Yutong et al. Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank [J]. | BIOMEDICINES , 2025 , 13 (3) . |
| MLA | Ma, Xiangge et al. "Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank" . | BIOMEDICINES 13 . 3 (2025) . |
| APA | Ma, Xiangge , Gao, Hongjian , Wu, Yutong , Zhu, Xinyu , Wu, Shuicai , Lin, Lan . Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank . | BIOMEDICINES , 2025 , 13 (3) . |
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Abstract ：
Fetal electrocardiogram (FECG) signals directly reflect the electrical activity of the fetal heart, enabling the assessment of fetal cardiac health. To effectively separate and extract FECG signals from maternal abdominal electrocardiogram (ECG) signals, this study proposed a W-shaped parallel network, termed Attention R2W-Net, which consisted of two Attention R2U-Nets. In the encoder and decoder, recurrent residual modules were used to replace feedforward convolutional layers, significantly enhancing feature representation and improving noise suppression. Additionally, attention gates were used to replace skip connections, enabling precise correction of low-resolution features using deep features and further improving model performance. The decoders at both ends of the network were utilized to reconstruct FECG and MECG signals, respectively. The algorithm was validated using simulated and real datasets, achieving F1 scores of 99.17%, 98.03%, and 97.08% on the ADFECGDB, PCDB, and NIFECGDB datasets, respectively, demonstrating superior performance in both subjective visual effects and objective evaluation metrics. Attention R2W-Net's ability to extract robustly and accurately FECG signals, even in complex noisy environments, make it a reliable tool for FECG extraction. The proposed method's efficiency and accuracy highlight its potential for widespread clinical application, contributing to improved early diagnosis of fetal cardiac abnormalities.
Keyword ：
recurrent residual convolution recurrent residual convolution Attention R2W-Net Attention R2W-Net fetal electrocardiogram signal extraction fetal electrocardiogram signal extraction
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| GB/T 7714 | Chen, Lin , Wu, Shuicai , Zhou, Zhuhuang . Fetal ECG Signal Extraction from Maternal Abdominal ECG Signals Using Attention R2W-Net [J]. | SENSORS , 2025 , 25 (3) . |
| MLA | Chen, Lin et al. "Fetal ECG Signal Extraction from Maternal Abdominal ECG Signals Using Attention R2W-Net" . | SENSORS 25 . 3 (2025) . |
| APA | Chen, Lin , Wu, Shuicai , Zhou, Zhuhuang . Fetal ECG Signal Extraction from Maternal Abdominal ECG Signals Using Attention R2W-Net . | SENSORS , 2025 , 25 (3) . |
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Abstract ：
The intricate dynamics of brain aging, especially the neurodegenerative mechanisms driving accelerated (ABA) and resilient brain aging (RBA), are pivotal in neuroscience. Understanding the temporal dynamics of these phenotypes is crucial for identifying vulnerabilities to cognitive decline and neurodegenerative diseases. Currently, there is a lack of comprehensive understanding of the temporal dynamics and neuroimaging biomarkers linked to ABA and RBA. This study addressed this gap by utilizing a large-scale UK Biobank (UKB) cohort, with the aim to elucidate brain aging heterogeneity and establish the foundation for targeted interventions. Employing Lasso regression on multimodal neuroimaging data, structural MRI (sMRI), diffusion MRI (dMRI), and resting-state functional MRI (rsfMRI), we predicted the brain age and classified individuals into ABA and RBA cohorts. Our findings identified 1949 subjects (6.2%) as representative of the ABA subpopulation and 3203 subjects (10.1%) as representative of the RBA subpopulation. Additionally, the Discriminative Event-Based Model (DEBM) was applied to estimate the sequence of biomarker changes across aging trajectories. Our analysis unveiled distinct central ordering patterns between the ABA and RBA cohorts, with profound implications for understanding cognitive decline and vulnerability to neurodegenerative disorders. Specifically, the ABA cohort exhibited early degeneration in four functional networks and two cognitive domains, with cortical thinning initially observed in the right hemisphere, followed by the temporal lobe. In contrast, the RBA cohort demonstrated initial degeneration in the three functional networks, with cortical thinning predominantly in the left hemisphere and white matter microstructural degeneration occurring at more advanced stages. The detailed aging progression timeline constructed through our DEBM analysis positioned subjects according to their estimated stage of aging, offering a nuanced view of the aging brain's alterations. This study holds promise for the development of targeted interventions aimed at mitigating age-related cognitive decline.
Keyword ：
brain age prediction brain age prediction UK biobank UK biobank multimodal neuroimaging multimodal neuroimaging resilient brain aging resilient brain aging accelerated brain aging accelerated brain aging discriminative event-based analysis discriminative event-based analysis
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| GB/T 7714 | Lin, Lan , Wu, Yutong , Liu, Lingyu et al. Understanding the Temporal Dynamics of Accelerated Brain Aging and Resilient Brain Aging: Insights from Discriminative Event-Based Analysis of UK Biobank Data [J]. | BIOENGINEERING-BASEL , 2024 , 11 (7) . |
| MLA | Lin, Lan et al. "Understanding the Temporal Dynamics of Accelerated Brain Aging and Resilient Brain Aging: Insights from Discriminative Event-Based Analysis of UK Biobank Data" . | BIOENGINEERING-BASEL 11 . 7 (2024) . |
| APA | Lin, Lan , Wu, Yutong , Liu, Lingyu , Sun, Shen , Wu, Shuicai . Understanding the Temporal Dynamics of Accelerated Brain Aging and Resilient Brain Aging: Insights from Discriminative Event-Based Analysis of UK Biobank Data . | BIOENGINEERING-BASEL , 2024 , 11 (7) . |
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Abstract ：
The detection of fetal ultrasound standard planes (FUSPs) is important for the diagnosis of fetal malformation and the prevention of perinatal death. As a promising deep-learning technique in FUSP detection, SonoNet's network parameters have a large size. In this paper, we introduced a light pyramid convolution (LPC) block into SonoNet and proposed LPC-SonoNet with reduced network parameters for FUSP detection. The LPC block used pyramid convolution architecture inspired by SimSPPF from YOLOv6 and was able to extract features from various scales with a small parameter size. Using SonoNet64 as the backbone, the proposed network removed one of the convolutional blocks in SonoNet64 and replaced the others with LPC blocks. The proposed LPC-SonoNet model was trained and tested on a publicly available dataset with 12,400 ultrasound images. The dataset with six categories was further divided into nine categories. The images were randomly divided into a training set, a validation set, and a test set in a ratio of 8:1:1. Data augmentation was conducted on the training set to address the data imbalance issue. In the classification of six categories and nine categories, LPC-SonoNet obtained the accuracy of 97.0% and 91.9% on the test set, respectively, slightly higher than the accuracy of 96.60% and 91.70% by SonoNet64. Compared with SonoNet64 with 14.9 million parameters, LPC-SonoNet had a much smaller parameter size (4.3 million). This study pioneered the deep-learning classification of nine categories of FUSPs. The proposed LPC-SonoNet may be used as a lightweight network for FUSP detection.
Keyword ：
fetal ultrasound fetal ultrasound standard plane standard plane convolutional neural network convolutional neural network deep learning deep learning image classification image classification
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| GB/T 7714 | Yu, Tianxiang , Tsui, Po-Hsiang , Leonov, Denis et al. LPC-SonoNet: A Lightweight Network Based on SonoNet and Light Pyramid Convolution for Fetal Ultrasound Standard Plane Detection [J]. | SENSORS , 2024 , 24 (23) . |
| MLA | Yu, Tianxiang et al. "LPC-SonoNet: A Lightweight Network Based on SonoNet and Light Pyramid Convolution for Fetal Ultrasound Standard Plane Detection" . | SENSORS 24 . 23 (2024) . |
| APA | Yu, Tianxiang , Tsui, Po-Hsiang , Leonov, Denis , Wu, Shuicai , Bin, Guangyu , Zhou, Zhuhuang . LPC-SonoNet: A Lightweight Network Based on SonoNet and Light Pyramid Convolution for Fetal Ultrasound Standard Plane Detection . | SENSORS , 2024 , 24 (23) . |
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Abstract ：
This study investigates the relationship between modifiable risk factors and dementia subtypes using data from 460,799 participants in the UK Biobank. Utilizing univariate Cox proportional hazards regression models, we examined the associations between 83 modifiable risk factors and the risks of all-cause dementia (ACD), Alzheimer's disease (AD), and vascular dementia (VD). Composite scores for different domains were generated by aggregating risk factors associated with ACD, AD, and VD, respectively, and their joint associations were assessed in multivariable Cox models. Additionally, population attributable fractions (PAF) were utilized to estimate the potential impact of eliminating adverse characteristics of the risk domains. Our findings revealed that an unfavorable medical history significantly increased the risk of ACD, AD, and VD (hazard ratios (HR) = 1.88, 95% confidence interval (95% CI): 1.74-2.03, p < 0.001; HR = 1.80, 95% CI: 1.54-2.10, p < 0.001; HR = 2.39, 95% CI: 2.10-2.71, p < 0.001, respectively). Blood markers (PAF = 12.1%; 17.4%) emerged as the most important risk domain for preventing ACD and VD, while psychiatric factors (PAF = 18.3%) were the most important for preventing AD. This study underscores the potential for preventing dementia and its subtypes through targeted interventions for modifiable risk factors. The distinct insights provided by HR and PAF emphasize the importance of considering both the strength of the associations and the population-level impact of dementia prevention strategies. Our research provides valuable guidance for developing effective public health interventions aimed at reducing the burden of dementia, representing a significant advancement in the field.
Keyword ：
risk domains risk domains Cox analysis Cox analysis population attributable fractions population attributable fractions risk factors risk factors dementia dementia
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| GB/T 7714 | Ma, Xiangge , Gao, Hongjian , Wu, Yutong et al. Investigating Modifiable Risk Factors Across Dementia Subtypes: Insights from the UK Biobank [J]. | BIOMEDICINES , 2024 , 12 (9) . |
| MLA | Ma, Xiangge et al. "Investigating Modifiable Risk Factors Across Dementia Subtypes: Insights from the UK Biobank" . | BIOMEDICINES 12 . 9 (2024) . |
| APA | Ma, Xiangge , Gao, Hongjian , Wu, Yutong , Zhu, Xinyu , Wu, Shuicai , Lin, Lan . Investigating Modifiable Risk Factors Across Dementia Subtypes: Insights from the UK Biobank . | BIOMEDICINES , 2024 , 12 (9) . |
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Abstract ：
The concept of 'brain age', derived from neuroimaging data, serves as a crucial biomarker reflecting cognitive vitality and neurodegenerative trajectories. In the past decade, machine learning (ML) and deep learning (DL) integration has transformed the field, providing advanced models for brain age estimation. However, achieving precise brain age prediction across all ages remains a significant analytical challenge. This comprehensive review scrutinizes advancements in ML- and DL-based brain age prediction, analyzing 52 peer-reviewed studies from 2020 to 2024. It assesses various model architectures, highlighting their effectiveness and nuances in lifespan brain age studies. By comparing ML and DL, strengths in forecasting and methodological limitations are revealed. Finally, key findings from the reviewed articles are summarized and a number of major issues related to ML/DL-based lifespan brain age prediction are discussed. Through this study, we aim at the synthesis of the current state of brain age prediction, emphasizing both advancements and persistent challenges, guiding future research, technological advancements, and improving early intervention strategies for neurodegenerative diseases.
Keyword ：
deep learning deep learning lifespan brain age lifespan brain age machine learning machine learning neuroimaging neuroimaging brain age prediction brain age prediction
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| GB/T 7714 | Wu, Yutong , Gao, Hongjian , Zhang, Chen et al. Machine Learning and Deep Learning Approaches in Lifespan Brain Age Prediction: A Comprehensive Review [J]. | TOMOGRAPHY , 2024 , 10 (8) : 1238-1262 . |
| MLA | Wu, Yutong et al. "Machine Learning and Deep Learning Approaches in Lifespan Brain Age Prediction: A Comprehensive Review" . | TOMOGRAPHY 10 . 8 (2024) : 1238-1262 . |
| APA | Wu, Yutong , Gao, Hongjian , Zhang, Chen , Ma, Xiangge , Zhu, Xinyu , Wu, Shuicai et al. Machine Learning and Deep Learning Approaches in Lifespan Brain Age Prediction: A Comprehensive Review . | TOMOGRAPHY , 2024 , 10 (8) , 1238-1262 . |
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Abstract ：
Objective: Aiming at the shortcomings of artificial surgical path planning for the thermal ablation of liver tumors, such as the time-consuming and labor-consuming process, and relying heavily on doctors' puncture experience, an automatic path-planning system for thermal ablation of liver tumors based on CT images is designed and implemented. Methods: The system mainly includes three modules: image segmentation and three-dimensional reconstruction, automatic surgical path planning, and image information management. Through organ segmentation and three- dimensional reconstruction based on CT images, the personalized abdominal spatial anatomical structure of patients is obtained, which is convenient for surgical path planning. The weighted summation method based on clinical constraints and the concept of Pareto optimality are used to solve the multi-objective optimization problem, screen the optimal needle entry path, and realize the automatic planning of the thermal ablation path. The image information database was established to store the information related to the surgical path. Results: In the discussion with clinicians, more than 78% of the paths generated by the planning system were considered to be effective, and the efficiency of system path planning is higher than doctors' planning efficiency. Conclusion: After improvement, the system can be used for the planning of the thermal ablation path of a liver tumor and has certain clinical application value.
Keyword ：
surgical planning surgical planning weighted summation weighted summation Pareto optimality Pareto optimality system design system design thermal ablation of tumors thermal ablation of tumors
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| GB/T 7714 | Song, Ziwei , Ding, Feifei , Wu, Weiwei et al. Design of Path-Planning System for Interventional Thermal Ablation of Liver Tumors Based on CT Images [J]. | SENSORS , 2024 , 24 (11) . |
| MLA | Song, Ziwei et al. "Design of Path-Planning System for Interventional Thermal Ablation of Liver Tumors Based on CT Images" . | SENSORS 24 . 11 (2024) . |
| APA | Song, Ziwei , Ding, Feifei , Wu, Weiwei , Zhou, Zhuhuang , Wu, Shuicai . Design of Path-Planning System for Interventional Thermal Ablation of Liver Tumors Based on CT Images . | SENSORS , 2024 , 24 (11) . |
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Abstract ：
In the realm of cognitive science, the phenomenon of "successful cognitive aging" stands as a hallmark of individuals who exhibit cognitive abilities surpassing those of their age-matched counterparts. However, it is paramount to underscore a significant gap in the current research, which is marked by a paucity of comprehensive inquiries that deploy substantial sample sizes to methodically investigate the cerebral biomarkers and contributory elements underpinning this cognitive success. It is within this context that our present study emerges, harnessing data derived from the UK Biobank. In this study, a highly selective cohort of 1060 individuals aged 65 and above was meticulously curated from a larger pool of 17,072 subjects. The selection process was guided by their striking cognitive resilience, ascertained via rigorous evaluation encompassing both generic and specific cognitive assessments, compared to their peers within the same age stratum. Notably, the cognitive abilities of the chosen participants closely aligned with the cognitive acumen commonly observed in middle-aged individuals. Our study leveraged a comprehensive array of neuroimaging-derived metrics, obtained from three Tesla MRI scans (T1-weighted images, dMRI, and resting-state fMRI). The metrics included image-derived phenotypes (IDPs) that addressed grey matter morphology, the strength of brain network connectivity, and the microstructural attributes of white matter. Statistical analyses were performed employing ANOVA, Mann-Whitney U tests, and chi-square tests to evaluate the distinctive aspects of IDPs pertinent to the domain of successful cognitive aging. Furthermore, these analyses aimed to elucidate lifestyle practices that potentially underpin the maintenance of cognitive acumen throughout the aging process. Our findings unveiled a robust and compelling association between heightened cognitive aptitude and the integrity of white matter structures within the brain. Furthermore, individuals who exhibited successful cognitive aging demonstrated markedly enhanced activity in the cerebral regions responsible for auditory perception, voluntary motor control, memory retention, and emotional regulation. These advantageous cognitive attributes were mirrored in the health-related lifestyle choices of the surveyed cohort, characterized by elevated educational attainment, a lower incidence of smoking, and a penchant for moderate alcohol consumption. Moreover, they displayed superior grip strength and enhanced walking speeds. Collectively, these findings furnish valuable insights into the multifaceted determinants of successful cognitive aging, encompassing both neurobiological constituents and lifestyle practices. Such comprehensive comprehension significantly contributes to the broader discourse on aging, thereby establishing a solid foundation for the formulation of targeted interventions aimed at fostering cognitive well-being among aging populations.
Keyword ：
multiparametric imaging multiparametric imaging cognitive resilience cognitive resilience MRI MRI cognitive aging cognitive aging neuroimaging neuroimaging
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| GB/T 7714 | Xu, Xinze , Lin, Lan , Wu, Shuicai et al. Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics [J]. | BRAIN SCIENCES , 2023 , 13 (12) . |
| MLA | Xu, Xinze et al. "Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics" . | BRAIN SCIENCES 13 . 12 (2023) . |
| APA | Xu, Xinze , Lin, Lan , Wu, Shuicai , Sun, Shen . Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics . | BRAIN SCIENCES , 2023 , 13 (12) . |
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Abstract ：
目的：目前较少有研究采用人工智能的方法分析冠状动脉造影(CAG),本文拟通过深度学习EfficientNet和Grad-CAM++可视化技术，实现冠状动脉造影体位的自动识别。方法：将86639张造影图片划分为训练集、验证集和测试集，均包括8个临床常用的造影体位。以准确率作为主要观察指标，评价EfficientNet-B1在各个投照体位上的分类效果，并解释模型的学习过程。结果：EfficientNet-B1在验证集和测试集上8个造影体位的平均准确率分别为：90.73%,89.40%,均高于传统的VGG-16和ResNet-18。且Grad-CAM++显示，EfficientNet-B1能学习到最为全面的冠状动脉。结论：EfficientNet-B1可以有效分辨临床常用的造影体位，学习效果要好于其他网络模型。
Keyword ：
Grad-CAM++ Grad-CAM++ EfficientNet EfficientNet 冠状动脉造影 冠状动脉造影 体位识别 体位识别
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| GB/T 7714 | 李劼慧 , 吴悔 , 曾研 et al. 基于EfficientNet和Grad-CAM++的冠状动脉造影体位识别方法的研究 [J]. | 生命科学仪器 , 2023 , 21 (06) : 82-88 . |
| MLA | 李劼慧 et al. "基于EfficientNet和Grad-CAM++的冠状动脉造影体位识别方法的研究" . | 生命科学仪器 21 . 06 (2023) : 82-88 . |
| APA | 李劼慧 , 吴悔 , 曾研 , 吴水才 . 基于EfficientNet和Grad-CAM++的冠状动脉造影体位识别方法的研究 . | 生命科学仪器 , 2023 , 21 (06) , 82-88 . |
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