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学者姓名:鲁理平
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Abstract :
A polymethionine (p-Met)-modified laser-induced graphene (LIG) electrode (p-Met/LIG) was constructed and integrated with a portable electrochemical workstation and handheld computer application to achieve simultaneous on-site detection of environmental water bodies. Among the azo dyes are sunset yellow (SY) and tartrazine (Tz). The laser processing parameters were optimized to prepare a sensing interface with the best conductive properties; Met was electropolymerized on the LIG surface to improve the electrochemical response of SY and Tz; by combining p-Met/LIG portable electrochemical sensors and small electrochemical workstations Integrated with a handheld computer application, a portable electrochemical sensing platform was built for detecting SY and Tz. Differential pulse voltammetry (DPV) was used to measure the two dyes, and the linear range of detecting SY was0.2-20 mu mol/Land 20-100 mu mol/L. The detection limit is as low as0.001 mu mol/L; The linear range of detecting Tz is0.3-40 mu mol/L and40-100 mu mol/L. The detection limit is0.005 mu mol/L.p-Met/LIG has excellent anti-interference performance, stability and reproducibility. This portable sensing platform was used for actual water sample detection, and the results showed that this platform is suitable for real-time on-site detection of SY and Tz in actual environmental water bodies
Keyword :
Portable Portable Electrochemical sensor Electrochemical sensor Sunset yellow Sunset yellow Azo dye Azo dye Tartrazine Tartrazine Laser induced graphene Laser induced graphene
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GB/T 7714 | Chang, Xue-Qing , Wang, Zi-Qi , Lu, Li-Ping . Portable electrochemical sensing platform for sensitive detection of azo dyes sunset yellow and tartrazine [J]. | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2024 , 52 (1) : 62-71 . |
MLA | Chang, Xue-Qing 等. "Portable electrochemical sensing platform for sensitive detection of azo dyes sunset yellow and tartrazine" . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 52 . 1 (2024) : 62-71 . |
APA | Chang, Xue-Qing , Wang, Zi-Qi , Lu, Li-Ping . Portable electrochemical sensing platform for sensitive detection of azo dyes sunset yellow and tartrazine . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2024 , 52 (1) , 62-71 . |
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A fast scan cyclic voltammetry (FSCV) electrochemical sensor based on multifunctional nanocomposite material Ti3C2/CuS for detection of trace mercury ions (Hg2+) was constructed in this work. Firstly, the high conductivity of Ti3C2 MXene was utilized to improve the charge transfer ability of the sensing interface. Secondly, the determination of Hg2+ with high selectivity was achieved by utilizing the characteristic of CuS solubility product constant being less than HgS. And by comparing the cyclic voltammetry phenomena under conventional scanning speed (0.1 V/s) and ultrafast scanning speed (350 V/s), it was found that on the basis of high-performance interface modification, ultrafast scanning speed could further enhance the current signal significantly. Under the optimal testing conditions, including buffer solution at pH=6, 5 mu L of composite material drop coating volume, and at an adsorption time of 15 min and a scanning rate of 350 V/s, the linear range for detecting Hg2+ was 0.5-50 pmol/L, and the detection limit was 0.5 pmol/L (S/N=3). This sensor had good selectivity, stability and reproducibility, and could be used for determination of trace mercury in actual lake water samples, with recoveries of 97.4%-102.3% and relative standard deviations <3.6%. The sensor was expected to have broad application prospects in emergency and on-site detection.
Keyword :
Trace mercury ions Trace mercury ions Fast scan cyclic voltammetry Fast scan cyclic voltammetry Electrochemical sensor Electrochemical sensor Chemical modified electrodes Chemical modified electrodes
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GB/T 7714 | Ji, Quan , Lu, Li-Ping . Determination of Trace Mercury Ions by Ti3C2/CuS Composite Modified Glassy Carbon Electrode Combined with Fast Scan Cyclic Voltammetry [J]. | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2023 , 51 (12) : 1915-1923 . |
MLA | Ji, Quan 等. "Determination of Trace Mercury Ions by Ti3C2/CuS Composite Modified Glassy Carbon Electrode Combined with Fast Scan Cyclic Voltammetry" . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 51 . 12 (2023) : 1915-1923 . |
APA | Ji, Quan , Lu, Li-Ping . Determination of Trace Mercury Ions by Ti3C2/CuS Composite Modified Glassy Carbon Electrode Combined with Fast Scan Cyclic Voltammetry . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2023 , 51 (12) , 1915-1923 . |
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Abstract :
In this study, a new strategy for NO detection based on the aggregation-induced electrochemical luminescence (AIECL) of a ruthenium-based complex and the halogen bonding effect was developed. First, [Ru(phen)(2)(phen-Br-2)](2+) (phen : 1,10-phenanthroline, phen-Br-2 : 3,8-dibromo-1,10-phenanthroline) was synthesized and exhibited aggregation-induced emission (AIE) and AIECL properties in a poor solvent (H2O). [Ru(phen)(2)(phen-Br-2)](2+) exhibited greatly enhanced AIECL properties compared to its AIE intensity. When the volume fraction of water (f(w), v %) in the H2O-acetonitrile (MeCN) system was increased from 30 to 90 %, the photoluminescence and electrochemiluminescence (ECL) intensities were three- and 800-fold that of the pure MeCN system, respectively. Dynamic light scattering and scanning electron microscopy results indicated that [Ru(phen)(2)(phen-Br-2)](2+) aggregated into nanoparticles. AIECL is sensitive to NO because of its halogen bonding effect. The C-Br center dot center dot center dot N bond between [Ru(phen)(2)(phen-Br-2)](2+) and NO increased the distance of complex molecules, resulting in ECL quenching. A detection limit of 2 nM was obtained with 5 orders of magnitude linear range. The combination of the AIECL system and the halogen bond effect expands the theoretical research and applications in biomolecular detection, molecular sensors, and stages of medical diagnosis.
Keyword :
halogen bonding halogen bonding nitric oxide nitric oxide molecular recognition molecular recognition ruthenium ruthenium aggregation-induced electrochemiluminescence aggregation-induced electrochemiluminescence
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GB/T 7714 | Gao, Yafang , Zhang, Linlin , Wang, Ziqi et al. Aggregation-Induced Electrochemiluminescence and Nitric Oxide Recognition by Halogen Bonding with a Ruthenium(II) Complex [J]. | CHEMPLUSCHEM , 2023 , 88 (3) . |
MLA | Gao, Yafang et al. "Aggregation-Induced Electrochemiluminescence and Nitric Oxide Recognition by Halogen Bonding with a Ruthenium(II) Complex" . | CHEMPLUSCHEM 88 . 3 (2023) . |
APA | Gao, Yafang , Zhang, Linlin , Wang, Ziqi , Lu, Liping . Aggregation-Induced Electrochemiluminescence and Nitric Oxide Recognition by Halogen Bonding with a Ruthenium(II) Complex . | CHEMPLUSCHEM , 2023 , 88 (3) . |
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Abstract :
Cadmium (Cd) can cause cell oxidative stress and cytotoxicity. Few studies have focused on inhibitory effects on Cd2+-induced oxidative stress and related cytotoxicity. Scanning electrochemical microscopy (SECM) is a highly sensitive and non-invasive electrochemical analytical method. However, no information exists on inhibitory effects on Cd2+-induced cell oxidative stress using SECM technology. Herein, we studied the effects of ascorbic acid (AsA), zinc chloride (ZnCl2), and calcium chelator 1,2-bis (2-aminophenoxy) ethane-N,N,N ',N '-tetraacetic acid tetraethoxy methyl ester (BAPTA-AM) on cell oxidative stress with SECM. Subsequently, we studied the inhibitory effects of AsA, ZnCl2, and BAPTA-AM on Cd2+-induced cell oxidative stress. Consequently, 50 mu mol L-1 AsA, 5 mu mol L-1 ZnCl2, and 5 mu mol L-1 BAPTA-AM did not produce reactive oxygen species (ROS) and had little effect on cell viability. However, they could significantly reduce Cd2+-induced excessive ROS and alleviate apoptosis (P < 0.01). Additionally, AsA had the strongest inhibitory effects on Cd2+-induced oxidative stress, followed by BAPTA-AM and ZnCl2. The inhibitory effects of AsA, ZnCl2, and BAPTA-AM on Cd2+-induced cytotoxicity might result from directly scavenging ROS and inhibiting oxidative stress-mediated signal transduction, enhancing antioxidant activities and maintaining cell membrane stabilities, and chelating excess calcium(2+) (Ca2+) to hinder its subsequent signal transduction, respectively. Scavenging excessive ROS and inhibiting cellular oxidative stress-mediated signal transduction might be the most effective way to alleviate Cd2+-induced cytotoxicity. Our study provides empirical evidence on the inhibitory effects of AsA, ZnCl2, and BAPTA-AM as specialized inhibitors against Cd2+-induced cellular oxidative stress and cytotoxicity, providing precious ideas for detoxifying toxic environmental metal pollutants.
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GB/T 7714 | Gao, Ke , Du, Yuying , Pan, Na et al. Study on inhibitory effects of AsA, ZnCl2, and BAPTA-AM on Cd2+-induced cell oxidative stress and cytotoxicity by scanning electrochemical microscopy (SECM) technology [J]. | SENSORS & DIAGNOSTICS , 2023 , 3 (1) : 135-146 . |
MLA | Gao, Ke et al. "Study on inhibitory effects of AsA, ZnCl2, and BAPTA-AM on Cd2+-induced cell oxidative stress and cytotoxicity by scanning electrochemical microscopy (SECM) technology" . | SENSORS & DIAGNOSTICS 3 . 1 (2023) : 135-146 . |
APA | Gao, Ke , Du, Yuying , Pan, Na , Zhou, Xuewei , Lu, Liping , Wang, Xiayan . Study on inhibitory effects of AsA, ZnCl2, and BAPTA-AM on Cd2+-induced cell oxidative stress and cytotoxicity by scanning electrochemical microscopy (SECM) technology . | SENSORS & DIAGNOSTICS , 2023 , 3 (1) , 135-146 . |
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Abstract :
The low concentration, high sensitivity and non-toxicity of co-reactant in electrochemiluminescence (ECL) systems are the key factors for the application in life analysis. Cysteamine (CS), a substance produced in the body of life , was used as the co-reactant to investigate the ECL property of Ru (bpy)(3)(2+) ECL system in this work. The results showed that CS as a co-reactant could significantly enhance the anodic ECL signal of Ru (bpy)(3)(2+) under neutral environment. The influences of experimental conditions including CS concentration, Ru (bpy)(3)(2+) concentration, pH value of buffer solution and other factors on ECL signal of the system were studied, and the mechanism of the novel ECL system was discussed. Based on the ECL signal of Ru (bpy)(3)(2+)-CS system quenching by hydrogen peroxide under optimal experimental conditions, the sensitive determination of hydrogen peroxide was achieved with a linear range of 5 x 10(-8)-5 x 10(-5) mol/L and a limit of detection of 10 nmol/L (S/N= 3). In view of the good biocompatibility and non-toxicity of CS, as well as the excellent ECL enhancement efficiency, this ECL system had significant application potential in biological analysis.
Keyword :
Electrochemiluminescence Electrochemiluminescence Co-reactant Co-reactant Hydrogen peroxide Hydrogen peroxide Ruthenium tribipyridine Ruthenium tribipyridine Cysteamine Cysteamine
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GB/T 7714 | GAO, Ya-Fang , LU, Li-Ping . A Novel Co-reactant of Ruthenium Tribipyridine for Sensitive Detection of Hydrogen Peroxide by Electrochemiluminescence [J]. | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2022 , 50 (12) : 1852-1859 . |
MLA | GAO, Ya-Fang et al. "A Novel Co-reactant of Ruthenium Tribipyridine for Sensitive Detection of Hydrogen Peroxide by Electrochemiluminescence" . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 50 . 12 (2022) : 1852-1859 . |
APA | GAO, Ya-Fang , LU, Li-Ping . A Novel Co-reactant of Ruthenium Tribipyridine for Sensitive Detection of Hydrogen Peroxide by Electrochemiluminescence . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2022 , 50 (12) , 1852-1859 . |
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Cadmium (Cd) is one of the most prevalent toxic metal pollutants, which is widely distributed in various environmental media and organisms. Literature studies have documented that Cd could stimulate cellular oxidative stress, and the increased intracellular reactive oxygen species (ROS) might destroy certain proteins and DNA and subsequently lead to cell apoptosis. Although several studies have studied the co-exposure between cadmium and other metals, information on the potential effects of Cd and its counterions is still lacking. In the present study, we explored the effects of nitrate and chloride on oxidative stress induced by Cd(ii) at environmental exposure levels in human breast cancer cells (MCF-7) using scanning electrochemical microscopy (SECM). After incubation in CdCl2 or Cd(NO3)(2), ROS production is concentration-dependent and time-dependent, and the variation trend is consistent. When MCF-7 cells were incubated at a constant Cd2+ concentration, it was found that the higher the concentration ratio of Cd(NO3)(2)/CdCl2, the less ROS was generated. Combined with cell-viability, intracellular acidification as well as antioxidants system tests, we observed that nitrate could be reduced to nitrite and then inhibit Cd-induced oxidative stress. Benefitting from real-time in situ imaging of cells by SECM, H2O2 was detected and quantified in a noninvasive way, and the effect of Cd at environmental exposure levels on cellular oxidative stress was explored deeper and more comprehensively. Prospectively, cytotoxicological methods based on the SECM technique would be established to explore toxic pollutant co-exposure issues at environmental exposure levels.
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GB/T 7714 | Pan, Na , Lu, Liping , Zhang, Dongtang et al. Evaluation of the effect of nitrate and chloride on Cd(ii)-induced cell oxidative stress by scanning electrochemical microscopy [J]. | ANALYTICAL METHODS , 2022 , 14 (27) : 2673-2681 . |
MLA | Pan, Na et al. "Evaluation of the effect of nitrate and chloride on Cd(ii)-induced cell oxidative stress by scanning electrochemical microscopy" . | ANALYTICAL METHODS 14 . 27 (2022) : 2673-2681 . |
APA | Pan, Na , Lu, Liping , Zhang, Dongtang , Wang, Xiayan . Evaluation of the effect of nitrate and chloride on Cd(ii)-induced cell oxidative stress by scanning electrochemical microscopy . | ANALYTICAL METHODS , 2022 , 14 (27) , 2673-2681 . |
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Abstract :
制备了金纳米粒子-氧化石墨烯(AuNPs-GO)复合物,采用透射电镜(TEM)和紫外-可见吸收光谱(UV-Vis)对其进行了表征。将此复合物修饰到玻碳电极(GCE)表面,再通过Au—S键将巯基修饰的富含鸟嘌呤的DNA链(T30695)自组装到电极表面的金纳米粒子上。T30695可与Pb~(2+)结合形成稳定的平行G-四链体,此G-四链体再与氯化血红素(Hemin)结合形成具有过氧化物酶活性的DNA酶(DNAzyme),基于此制得Pb~(2+)敏感的DNA酶电化学传感器。形成的DNA酶可催化H_2O_2氧化对苯二酚(HQ),实现电化学信号的放大和Pb~(2+)的高灵敏检测。在优化的实验条件下,在...
Keyword :
DNA酶 DNA酶 方波伏安法 方波伏安法 铅离子(Ⅱ) 铅离子(Ⅱ) 传感器 传感器
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GB/T 7714 | 杨瑞 , 康天放 , 鲁理平 et al. 基于DNA酶/AuNPs-GO传感器方波伏安法高灵敏检测Pb~(2+) [J]. | 分析化学 , 2021 , 49 (02) : 309-317 . |
MLA | 杨瑞 et al. "基于DNA酶/AuNPs-GO传感器方波伏安法高灵敏检测Pb~(2+)" . | 分析化学 49 . 02 (2021) : 309-317 . |
APA | 杨瑞 , 康天放 , 鲁理平 , 叶青 . 基于DNA酶/AuNPs-GO传感器方波伏安法高灵敏检测Pb~(2+) . | 分析化学 , 2021 , 49 (02) , 309-317 . |
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Abstract :
基于MoS2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II)
Keyword :
溶出伏安法 溶出伏安法 二硫化钼 二硫化钼 氮掺杂石墨烯 氮掺杂石墨烯 镉 镉
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GB/T 7714 | 于志辉 , 蒲渝文 , 鲁理平 et al. 基于MoS2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II) [J]. | 于志辉 , 2021 , 40 (1) : 17-20 . |
MLA | 于志辉 et al. "基于MoS2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II)" . | 于志辉 40 . 1 (2021) : 17-20 . |
APA | 于志辉 , 蒲渝文 , 鲁理平 , 分析试验室 . 基于MoS2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II) . | 于志辉 , 2021 , 40 (1) , 17-20 . |
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Abstract :
基于S-Cd和N-Cd的亲和作用,利用一锅法制备了MoS_2-掺氮石墨烯(NG)新型纳米复合材料。采用方波溶出伏安法实现了Cd~(2+)的灵敏测定。在最优实验条件下,Cd~(2+)的溶出峰电流与Cd~(2+)的浓度在0.01~20μmol/L范围内呈线性关系(R~2=0.996),检出限为2.50 nmol/L。该传感器可用于监测实际样品中Cd~(2+)。
Keyword :
二硫化钼 二硫化钼 氮掺杂石墨烯 氮掺杂石墨烯 溶出伏安法 溶出伏安法 镉 镉
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GB/T 7714 | 于志辉 , 蒲渝文 , 鲁理平 . 基于MoS_2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II) [J]. | 分析试验室 , 2021 , 40 (01) : 17-20 . |
MLA | 于志辉 et al. "基于MoS_2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II)" . | 分析试验室 40 . 01 (2021) : 17-20 . |
APA | 于志辉 , 蒲渝文 , 鲁理平 . 基于MoS_2/氮掺杂石墨烯纳米复合材料灵敏电化学传感器检测镉(II) . | 分析试验室 , 2021 , 40 (01) , 17-20 . |
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Abstract :
Dopamine participates in many physiological and pathological processes. Dynamic monitoring of dopamine levels in the cytoplasm of a single living cell reflects not only the functional state of dopamine synthesis factors but also the processes of related neurodegenerative diseases. Due to the low content of cytoplasmic dopamine and the difficulty to keep cells alive during the operating process, the detection of cytoplasmic dopamine is still challenging. Herein, a solid-phase microextraction (SPME) technique integrated nanobiosensor was employed to trace and quantify dopamine concentration fluctuations in the cytoplasm of a single living cell. We designed a polypyrrole modified carbon fiber nanoprobe as a bifunctional nanoprobe that can extract cytoplasmic dopamine and then perform electrochemical detection. This bifunctional nanoprobe can detect 10 pmol/L extracted dopamine and detected a 60% decrease of the cytoplasmic dopamine concentration in a single living cell by K+ stimulation. This study allowed for the first time serially detecting cytoplasmic dopamine while keeping the target cell alive, which might yield a new method for research on dopamine neurotoxicity and the related drug action mechanisms for neurodegenerative disease.
Keyword :
Dopamine Dopamine Solid-phase microextraction (SPME) Solid-phase microextraction (SPME) Cytoplasm Cytoplasm Electrochemistry Electrochemistry Nano-based biosensor Nano-based biosensor
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GB/T 7714 | Chang Yaran , Chen Yongjia , Shao Yunlong et al. Solid-phase microextraction integrated nanobiosensors for the serial detection of cytoplasmic dopamine in a single living cell. [J]. | Biosensors & bioelectronics , 2021 , 175 : 112915 . |
MLA | Chang Yaran et al. "Solid-phase microextraction integrated nanobiosensors for the serial detection of cytoplasmic dopamine in a single living cell." . | Biosensors & bioelectronics 175 (2021) : 112915 . |
APA | Chang Yaran , Chen Yongjia , Shao Yunlong , Li Boye , Wu Yuanyuan , Zhang Wenmei et al. Solid-phase microextraction integrated nanobiosensors for the serial detection of cytoplasmic dopamine in a single living cell. . | Biosensors & bioelectronics , 2021 , 175 , 112915 . |
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