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学者姓名：王娟
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Abstract ：
Macroautophagy involves the encapsulation of cellular components within double-membrane autophagosomes for subsequent degradation in vacuoles or lysosomes. Coat protein complex II (COPII) vesicles serve as a membrane source for autophagosome formation. However, the specific role of SEC24D, an isoform of the COPII coat protein SEC24, in the macroautophagy pathway remains unclear. In this study, we demonstrate that SEC24D is indispensable for macroautophagy and important for autophagosome closure. Depletion of SEC24D leads to the accumulation of unsealed isolation membranes. Furthermore, under conditions of starvation, SEC24D interacts with casein kinase1 delta (CK1 delta), a member of the casein kinase 1 family, and autophagy-related 9A (ATG9A). Collectively, our findings unveil the indispensable role of SEC24D in starvation-induced autophagy in mammalian cells.
Keyword ：
isolation membrane isolation membrane autophagosome closure autophagosome closure COPII COPII SEC24D SEC24D autophagy autophagy
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| GB/T 7714 | He, Tianlong , Ji, Cuicui , Zhang, Wenting et al. The COPII coat protein SEC24D is required for autophagosome closure in mammals [J]. | FEBS LETTERS , 2024 , 598 (23) : 2897-2909 . |
| MLA | He, Tianlong et al. "The COPII coat protein SEC24D is required for autophagosome closure in mammals" . | FEBS LETTERS 598 . 23 (2024) : 2897-2909 . |
| APA | He, Tianlong , Ji, Cuicui , Zhang, Wenting , Li, Xianghua , Liu, Yukun , Wang, Xiaoli et al. The COPII coat protein SEC24D is required for autophagosome closure in mammals . | FEBS LETTERS , 2024 , 598 (23) , 2897-2909 . |
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Abstract ：
服务业的扩大对外开放已成为中国构建新发展格局的重要一环。服务业的快速扩张和高水平对外开放，不仅为中国带来了经济繁荣，也是适应新发展阶段和应对全球经贸变革的重要举措。目前，中国存在服务业对外开放度较低及制度性障碍等问题。本文对中国服务业开放度测算的结果表明，现阶段中国服务业开放度远低于世界平均水平。基于此，本文提出了中国服务业开放度的提升路径，即利用区域协定深度参与国际合作、推动服务业体制改革、推行服务行业有序开放、调动基层政府促进开放积极性和建立服务型企业开放平台等。
Keyword ：
测算 测算 服务业 服务业 困境 困境 对外开放度 对外开放度 路径 路径
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| GB/T 7714 | 王娟 , 耿琳 . 中国服务业对外开放水平与提升路径研究 [J]. | 中国物价 , 2023 , PageCount-页数: 4 (11) : 11-13,20 . |
| MLA | 王娟 et al. "中国服务业对外开放水平与提升路径研究" . | 中国物价 PageCount-页数: 4 . 11 (2023) : 11-13,20 . |
| APA | 王娟 , 耿琳 . 中国服务业对外开放水平与提升路径研究 . | 中国物价 , 2023 , PageCount-页数: 4 (11) , 11-13,20 . |
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Abstract ：
Hrr25是酿酒酵母中Ⅰ型酪蛋白激酶家族成员，具有丝氨酸/苏氨酸蛋白激酶活性。其可以通过磷酸化多种蛋白质来发挥作用。Hrr25的底物蛋白质包括自噬相关蛋白、COPⅡ(coat protein complexes Ⅱ)囊泡衣被蛋白Sec24和Sec23、真核翻译起始因子6、γ-微管蛋白Tub4、延长器复合蛋白1等。另外Hrr25还可以与减数分裂重组蛋白Rec8、核孔蛋白Nup53、转录调节因子Crz1、转录激活因子Haa1等相互作用。Hrr25的多种相互作用蛋白质使其在自噬、囊泡运输、微管组装、减数分裂、有丝分裂、DNA修复、核糖体生物发生和弱有机酸胁迫途径等多种生物过程发挥作用。为了更好地了解Hrr25在各个生物过程中的作用机制以及各个生物过程之间的联系，本文总结了Hrr25的生物学功能及其作用机制，并概述其研究的潜在意义，为Hrr25的进一步研究提供理论依据。
Keyword ：
细胞分裂 细胞分裂 Hrr25 Hrr25 酿酒酵母 酿酒酵母 囊泡运输 囊泡运输
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| GB/T 7714 | 姜文艳 , 张文婷 , 王娟 . Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制 [J]. | 中国生物化学与分子生物学报 , 2023 , 39 (08) : 1079-1086 . |
| MLA | 姜文艳 et al. "Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制" . | 中国生物化学与分子生物学报 39 . 08 (2023) : 1079-1086 . |
| APA | 姜文艳 , 张文婷 , 王娟 . Ⅰ型酪蛋白激酶Hrr25的生物学功能和作用机制 . | 中国生物化学与分子生物学报 , 2023 , 39 (08) , 1079-1086 . |
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Abstract ：
Aloperine is an alkaloid found in the seeds and leaves of the medicinal plant Sophora alopecuroides L. It has been used as herbal medicine in China for centuries due to its potent anti-inflammatory, antioxidant, antibacterial, and antiviral properties. Recently, aloperine has been widely investigated for its therapeutic activities. Aloperine is proven to be an effective therapeutic agent against many human pathological conditions, including cancer, viral diseases, and cardiovascular and inflammatory disorders. Aloperine is reported to exert therapeutic effects through triggering various biological processes, including cell cycle arrest, apoptosis, autophagy, suppressing cell migration, and invasion. It has also been found to be associated with the modulation of various signaling pathways in different diseases. In this review, we summarize the most recent knowledge on the modulatory effects of aloperine on various critical biological processes and signaling mechanisms, including the PI3K, Akt, NF-kappa B, Ras, and Nrf2 pathways. These data demonstrate that aloperine is a promising therapeutic candidate. Being a potent modulator of signaling mechanisms, aloperine can be employed in clinical settings to treat various human disorders in the future.
Keyword ：
autophagy autophagy Ras Ras PI3K/Akt PI3K/Akt cell cycle cell cycle Nrf2 Nrf2 NF-kappa B NF-kappa B apoptosis apoptosis
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| GB/T 7714 | Tahir, Muhammad , Ali, Sakhawat , Zhang, Wenting et al. Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases [J]. | BIOMEDICINES , 2022 , 10 (4) . |
| MLA | Tahir, Muhammad et al. "Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases" . | BIOMEDICINES 10 . 4 (2022) . |
| APA | Tahir, Muhammad , Ali, Sakhawat , Zhang, Wenting , Lv, Boqiang , Qiu, Wenge , Wang, Juan . Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases . | BIOMEDICINES , 2022 , 10 (4) . |
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Abstract ：
本文选取了2005-2018年的商品相关服务贸易数据,对贸易总量、进出口结构进行了比较,测算了贸易竞争力、显示比较优势、出口相似性指数,并采用扩展的贸易引力模型对商品相关服务贸易的影响因素进行实证分析。结果表明,中国商品服务贸易竞争力有所下降,但仍具有较强的竞争优势。中国与多国商品相关服务贸易出口的相似度很低,几乎没有竞争。GDP、国际市场份额、对外开放度、FDI和人口与货物相关服务贸易呈正相关,与距离呈负相关。
Keyword ：
商品相关服务贸易 商品相关服务贸易 建议 建议 引力模型 引力模型 竞争性 竞争性
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| GB/T 7714 | 王娟 , 徐薇 , 周语嫣 . 商品相关服务贸易竞争性与影响因素研究 [J]. | 中国物价 , 2021 , PageCount-页数: 4 (10) : 48-51 . |
| MLA | 王娟 et al. "商品相关服务贸易竞争性与影响因素研究" . | 中国物价 PageCount-页数: 4 . 10 (2021) : 48-51 . |
| APA | 王娟 , 徐薇 , 周语嫣 . 商品相关服务贸易竞争性与影响因素研究 . | 中国物价 , 2021 , PageCount-页数: 4 (10) , 48-51 . |
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Abstract ：
Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.
Keyword ：
closure closure isolation membrane isolation membrane autophagosome autophagosome autophagy autophagy
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| GB/T 7714 | Jiang, Wenyan , Chen, Xuechai , Ji, Cuicui et al. Key Regulators of Autophagosome Closure [J]. | CELLS , 2021 , 10 (11) . |
| MLA | Jiang, Wenyan et al. "Key Regulators of Autophagosome Closure" . | CELLS 10 . 11 (2021) . |
| APA | Jiang, Wenyan , Chen, Xuechai , Ji, Cuicui , Zhang, Wenting , Song, Jianing , Li, Jie et al. Key Regulators of Autophagosome Closure . | CELLS , 2021 , 10 (11) . |
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Abstract ：
To obtain new anticancer agents with antimetastatic adjunct efficacy, a series of novel N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were designed and synthesized by an eight-step reaction, with appropriate yields. All the synthesized compounds were evaluated for their antiproliferative activity against A549 and MCF-7 cells and for antiplatelet aggregation activity in vitro. The results showed that compounds 25 and 35 not only showed potent antiproliferative activity against the A549 (IC50 = 15.3 and 21.4 mu M) and MCF-7 (IC50 = 15.6 and 10.9 mu M) cell lines but also showed certain antiplatelet aggregation activity (inhibition rates: 47.0% and 45.8%). These results indicated that the structural modification on the N-4-hydrazone moiety of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one is promising to obtain novel anticancer compounds with antimetastatic adjunct efficacy. In addition, a molecular docking study was performed to investigate the possible targets, and these results indicated that compounds 25 and 35 have the potential to target EGFR, HER2, and P2Y(12).
Keyword ：
antimetastatic antimetastatic 3-d]pyrimidin-6-one 3-d]pyrimidin-6-one anticancer anticancer synthesis synthesis hydrazone hydrazone pyrrolo[2 pyrrolo[2
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| GB/T 7714 | Zhao, Zhichang , Wang, Hongjun , Tian, Nana et al. Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy [J]. | ARCHIV DER PHARMAZIE , 2021 , 354 (11) . |
| MLA | Zhao, Zhichang et al. "Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy" . | ARCHIV DER PHARMAZIE 354 . 11 (2021) . |
| APA | Zhao, Zhichang , Wang, Hongjun , Tian, Nana , Yan, Hong , Wang, Juan . Synthesis and biological evaluation of N-4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy . | ARCHIV DER PHARMAZIE , 2021 , 354 (11) . |
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Abstract ：
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related (ATG) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies.
Keyword ：
m6A m6A Azoospermatism Azoospermatism RNA methylation RNA methylation Cancer Cancer Autophagy Autophagy Obesity Obesity Ischemic heart disease Ischemic heart disease
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| GB/T 7714 | Chen, Xuechai , Wang, Jianan , Tahir, Muhammad et al. Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases [J]. | CELL AND BIOSCIENCE , 2021 , 11 (1) . |
| MLA | Chen, Xuechai et al. "Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases" . | CELL AND BIOSCIENCE 11 . 1 (2021) . |
| APA | Chen, Xuechai , Wang, Jianan , Tahir, Muhammad , Zhang, Fangfang , Ran, Yuanyuan , Liu, Zongjian et al. Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases . | CELL AND BIOSCIENCE , 2021 , 11 (1) . |
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Abstract ：
当今,大多数国家正在加深制造业与服务业的融合。本文以OECD-TiVA数据库为基础,尝试从附加值贸易的角度来计算具有代表性的40个国家制造业出口技术复杂度;利用面板数据考察了生产者服务进口对所有样本国家制造业附加值出口技术复杂度的影响程度,从而探索各国之间的共性与差异性的问题。研究发现,整体生产者服务进口对发达国家与发展中国家的制造业附加值出口技术复杂度均具有正向的影响,其对发展中国家制造业附加值出口技术复杂度的提升作用往往大于发达国家。从分部门进口生产者服务中间投入的视角分析,发现金融服务与运输服务进口对样本国家的影响较大,且不同的生产者服务进口的影响程度是存在差异的。
Keyword ：
附加值出口技术复杂度 附加值出口技术复杂度 制造业 制造业 金融服务 金融服务 生产者服务进口 生产者服务进口 国内附加值 国内附加值 运输服务进口 运输服务进口
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| GB/T 7714 | 王娟 , 韩玉军 , 李靖 et al. 生产者服务进口对出口技术复杂度的影响研究——基于制造业附加值贸易的视角 [J]. | 工业技术经济 , 2020 , 39 (04) : 72-80 . |
| MLA | 王娟 et al. "生产者服务进口对出口技术复杂度的影响研究——基于制造业附加值贸易的视角" . | 工业技术经济 39 . 04 (2020) : 72-80 . |
| APA | 王娟 , 韩玉军 , 李靖 , 单文博 , 邓钧霞 . 生产者服务进口对出口技术复杂度的影响研究——基于制造业附加值贸易的视角 . | 工业技术经济 , 2020 , 39 (04) , 72-80 . |
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Abstract ：
Purpose Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and ranked top in terms of incidence and mortality in men and women. Recently, improvements in treatment approaches for NSCLC have reported, but still, there is a need to devise innovative treatment strategies, especially to manage the advanced and metastatic stage of NSCLC. Aloperine (ALO), an herbal alkaloid, has exerted anti-cancer effects in many cancers. However, the use of any chemotherapeutic agents is dose limited due to possible adverse effects and drug-resistance issues. Therefore, a combination of chemotherapy with viral-based targeted gene therapy may provide a novel treatment strategy for NSCLC. Methods/results In this study, the results of the MTT and flow cytometry-based assays showed that Aloperine-Adbic (adenoviral vector expressing p14(ARF)/p53) combined treatment on NSCLC cells synergistically produced anti-proliferative effects, induced apoptosis, and arrested cell cycle at the G1 phase. Furthermore, the expression analysis suggested that the p53/p21 pathway might contribute to achieving aforesaid cytotoxic effects. The ALO-Adbic combined treatment prolonged the percent survival of NSCLC xenograft models. Conclusion In conclusion, ALO-Adbic combination can produce synergistic anti-cancer effects at low doses, and may offer a more effective and less toxic new treatment strategy for NSCLC.
Keyword ：
NSCLC NSCLC Aloperine Aloperine Adenoviral vectors Adenoviral vectors p53 p53 Synergy Synergy
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| GB/T 7714 | Muhammad, Tahir , Sakhawat, Ali , Khan, Aamir Ali et al. Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer [J]. | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY , 2020 , 146 (4) : 861-874 . |
| MLA | Muhammad, Tahir et al. "Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer" . | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 146 . 4 (2020) : 861-874 . |
| APA | Muhammad, Tahir , Sakhawat, Ali , Khan, Aamir Ali , Huang, Hua , Khan, Haroon Rashid , Huang, Yinghui et al. Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer . | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY , 2020 , 146 (4) , 861-874 . |
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