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学者姓名：张红胜
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Abstract ：
Amino acids act as versatile nutrients driving cell growth and survival, especially in cancer cells. Amino acid metabolism comprises numerous metabolic networks and is closely linked with intracellular redox balance and epigenetic regulation. Reprogrammed amino acid metabolism has been recognized as a ubiquitous feature in tumour cells. This review outlines the metabolism of several primary amino acids in cancer cells and highlights the pivotal role of amino acid metabolism in sustaining redox homeostasis and regulating epigenetic modification in response to oxidative and genetic stress in cancer cells.
Keyword ：
epigenetic regulation epigenetic regulation cancer cancer redox balance redox balance amino acids amino acids metabolism metabolism
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| GB/T 7714 | Li, Xiang , Zhang, Hong-Sheng . Amino acid metabolism, redox balance and epigenetic regulation in cancer [J]. | FEBS JOURNAL , 2023 , 291 (3) : 412-429 . |
| MLA | Li, Xiang 等. "Amino acid metabolism, redox balance and epigenetic regulation in cancer" . | FEBS JOURNAL 291 . 3 (2023) : 412-429 . |
| APA | Li, Xiang , Zhang, Hong-Sheng . Amino acid metabolism, redox balance and epigenetic regulation in cancer . | FEBS JOURNAL , 2023 , 291 (3) , 412-429 . |
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Abstract ：
Breast cancer has become the first rank cancer in the world,and the exploration of the pathogenesisand treatment of breast cancer deserves more and more attention.Lipid metabolism dysfunction is one of the mostprominent metabolic changes in cancer cells.It is very important to explore the changes of lipid metabolism inbreast cancer cells in order to find new diagnostic indicators and therapeutic targets.This paper introduces theresearch progress of lipid metabolism dysfunction in breast cancer from4aspects:(1)the expression of abnormalfatty acid metabolism in breast cancer from three aspects of fatty acid synthesis,oxidation and uptake and therelated research progress;(2)introduction to the abnormal expression of triglyceride metabolism in breast cancerfrom the aspects of triglyceride synthesis and degradation and the related research progress;(3)to introduce theabnormal expression of cholesterol synthase in breast cancer and the related research progress;(4)to introducethe abnormal expression of lipid metabolism signaling pathways in breast cancer from five signaling pathways,namely Notch,Hippo,Hedgehog,Wnt and mTOR,and the related research progress.The aim is to provide newideas and methods for targeting lipid metabolism in the treatment of breast cancer
Keyword ：
lipid metabolism lipid metabolism triglyceride metabolism triglyceride metabolism fatty acid metabolism fatty acid metabolism breast cancer breast cancer cholesterol metabolism cholesterol metabolism
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| GB/T 7714 | Wang Miao , Wang Xin-Yu , Li Hong-Ming et al. The Progress of Lipid Metabolism in Breast Cancer br [J]. | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2022 , 49 (6) : 1052-1060 . |
| MLA | Wang Miao et al. "The Progress of Lipid Metabolism in Breast Cancer br" . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 49 . 6 (2022) : 1052-1060 . |
| APA | Wang Miao , Wang Xin-Yu , Li Hong-Ming , Zhang Hong-Sheng . The Progress of Lipid Metabolism in Breast Cancer br . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2022 , 49 (6) , 1052-1060 . |
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Abstract ：
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and major cause of cancer death in the world. Ferroptosis is a recently identified type of regulated cell death. Increasing evidence has shown that ferroptosis plays an important regulatory role in the occurrence and development of cancer. This study identified TIGAR as a potential regulator of ferroptosis resistance in the development of CRC. We showed that TIGAR expression in CRC tissues is significantly higher than that in adjacent normal tissues. Knockdown of TIGAR significantly caused an increase in erastin-induced ferroptosis in SW620 and HCT116 cells. Notably, knockdown of TIGAR significantly decreased GSH/GSSG ratio, increased lipid peroxidation production, and facilitated the accumulation of lipid peroxidation product malondialdehyde (MDA), and rendered CRC cells more sensitive to erastin induced ferroptosis. Furthermore, TIGAR inhibition repressed SCD1 expression in a redox and AMPK-dependent manner. Thus, these results suggest that TIGAR induces ferroptosis resistance in CRC cells via the ROS/AMPK/SCD1 signaling pathway.
Keyword ：
TIGAR TIGAR AMPK AMPK Ferroptosis Ferroptosis SCD1 SCD1 Redox Redox
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| GB/T 7714 | Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway [J]. | FREE RADICAL BIOLOGY AND MEDICINE , 2022 , 182 : 219-231 . |
| MLA | Liu, Min-Yao et al. "TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway" . | FREE RADICAL BIOLOGY AND MEDICINE 182 (2022) : 219-231 . |
| APA | Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Xia, Ran , Li, Xiang , Ma, Yu-Jie et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway . | FREE RADICAL BIOLOGY AND MEDICINE , 2022 , 182 , 219-231 . |
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Abstract ：
药理学线上线下混合式教学的思考与实践
Keyword ：
线上线下混合式教学 线上线下混合式教学 慕课 慕课 课程思政 课程思政 药理学 药理学
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| GB/T 7714 | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 [J]. | 张红胜 , 2021 , 19 (5) : 155-158 . |
| MLA | 张红胜 et al. "药理学线上线下混合式教学的思考与实践" . | 张红胜 19 . 5 (2021) : 155-158 . |
| APA | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 . | 张红胜 , 2021 , 19 (5) , 155-158 . |
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Abstract ：
Cancer cells can metabolize glutamine to replenish TCA cycle intermediates for cell survival. Glutaminase (GLS1) is over-expressed in multiple cancers, including colorectal cancer (CRC). However, the role of GLS1 in colorectal cancer development has not yet fully elucidated. In this study, we found that GLS1 levels were significantly increased in CRC cells. Knockdown of GLS1 by shRNAs as well as GLS1 inhibitor BPTES decreased DLD1 and SW480 cell proliferation, colony formation and migration. Knockdown of GLS1 as well as BPTES induced reactive oxygen species (ROS) production, down-regulation of GSH/GSSG ratio, an decrease in Nrf2 protein expression and an increase in cytoplasmic Nrf2 protein expression in DLD1 and SW480 cells. Furthermore, Knockdown of GLS1 as well as BPTES inhibited autophagy pathway, antioxidant NAC and Nrf2 activator could reversed inhibition of GLS1-mediated an decrease in autophagic flux in DLD1 and SW480 cells. Depletion of GLS1-induced inhibition of DLD1 and SW480 CRC cell proliferation, colony formation and migration was reversed by autophagy inducer rapamycin. These results suggest that targeting GLS1 might be a new potential therapeutic target for the treatment of CRC.
Keyword ：
GLS1 GLS1 Redox Redox Autophagy Autophagy Colorectal cancer Colorectal cancer
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| GB/T 7714 | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao et al. GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway [J]. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
| MLA | Liu, Hui-Yun et al. "GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway" . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 708 (2021) . |
| APA | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Wang, Miao . GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
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Abstract ：
课程思政是新时期高校教育新模式.如何充分发掘医学基础专业基础课程蕴含的课程思政元素,将其融入教学实践过程中,对实现三全育人,引导学生建立正确的人生观、价值观及职业观,具有重要的现实意义.通过对医学基础的课程思政元素和教案设计进行探索与实践,设计医学基础课程思政的切入点、思路.通过教学实践与教学反思,准确地把握思想政治教育的时机与方法.主要探索课程思政与医学基础课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
Keyword ：
医学基础 医学基础 思想政治教育 思想政治教育 三全育人 三全育人
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| GB/T 7714 | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 [J]. | 教育教学论坛 , 2021 , (38) : 58-61 . |
| MLA | 张红胜 et al. "研究生医学基础课程思政教学的探索与实践" . | 教育教学论坛 38 (2021) : 58-61 . |
| APA | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 . | 教育教学论坛 , 2021 , (38) , 58-61 . |
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Abstract ：
如何充分发掘药理学专业基础课程所蕴含的课程思政元素,将其融入日常教学,对实现三全育人,引导当代大学生建立正确人生观、价值观及职业观,具有重要的现实意义.本文主要从探索课程思政与药理学专业课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
Keyword ：
三全育人 三全育人 课程思政 课程思政 多元式教学 多元式教学
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| GB/T 7714 | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 [J]. | 产业与科技论坛 , 2021 , 20 (10) : 153-154 . |
| MLA | 张红胜 . "学科历史与学科前沿融入药理学课程思政的探索与实践" . | 产业与科技论坛 20 . 10 (2021) : 153-154 . |
| APA | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 . | 产业与科技论坛 , 2021 , 20 (10) , 153-154 . |
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Abstract ：
Road datasets are fundamental and imperative for traffic management and urban planning. Different high resolution optical remote sensing images are widely used for automatic road extraction but the results are usually limited to local scale and spectral confusions in barren and cropland, while accurate large-scale road extraction remains challenging. In this study, we incorporated medium resolution optical and SAR data, i.e., 10 meter resolution Sentinel-1 and Sentinel-2, for road extraction at a large scale and evaluated the contribution of different data sources. We developed a United U-Net (UU-Net) to fuse optical and SAR data for road extraction, which was trained and evaluated on a large-scale multisource road extraction dataset. The UU-Net achieved better accuracy than traditional deep convolutional networks with optical or SAR data alone, which obtained an average F1 of 0.5502 and an average IoU of 0.4021, outperforming in 160 out of 200 (80%) 0.5-by-0.5 degree evaluation grids. The results indicated that SAR contributes more to road extraction in barren land, while optical data contributes more to large slope areas. The road accuracy is positively related to elevation and urban percentage, which distributes higher in eastern China and lower in western. The road centerline from 10 m road showed comparable results with that from Open Street Map (OSM), indicating its promising applications to support large-scale urban transportation studies.
Keyword ：
U-Net U-Net SAR SAR OSM OSM Road Road Optical Optical
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| GB/T 7714 | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction [J]. | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
| MLA | Lin, Yinyi et al. "Leveraging optical and SAR data with a UU-Net for large-scale road extraction" . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION 103 (2021) . |
| APA | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng , Wei, Shan , Ma, Peifeng , Li, Yu et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
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Abstract ：
培养学生自主学习与创新能力是高等教育的重要任务.药理学课程内容烦琐以及概念抽象成为教学难点.在药理学教学过程中,引入FDA最新批准的新药研讨式教学作为创新性教学方法,将"以学生为中心"的教育理念渗透到药理学教学的全过程,提出了自主学习理念下的药理学混合教学策略.该方法提高了教学效果,提高了学生学习药理学的积极性,培养了学生自主学习能力和创新性思维能力,增强了学生科研兴趣,培养了学生的团队协作意识.
Keyword ：
新药药理 新药药理 药理学 药理学 教学改革 教学改革
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| GB/T 7714 | 张红胜 , 孙洪亮 , 刘慧云 . FDA批准的新药研讨式教学在药理学课堂的实践与探索 [J]. | 教育教学论坛 , 2020 , (34) : 264-266 . |
| MLA | 张红胜 et al. "FDA批准的新药研讨式教学在药理学课堂的实践与探索" . | 教育教学论坛 34 (2020) : 264-266 . |
| APA | 张红胜 , 孙洪亮 , 刘慧云 . FDA批准的新药研讨式教学在药理学课堂的实践与探索 . | 教育教学论坛 , 2020 , (34) , 264-266 . |
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Abstract ：
Aims: Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality worldwide. Over-expression of tetraspanin 8 (TSPAN8) is related to the development and progression of CRC. Whether TSPAN8 plays a role in the growth of colorectal cancer and its epigenetic mechanisms regulated by Lysine Specific Demethylase 1 (LSD1) are still unknown. Main methods: In this study, RT-PCR and western blotting were used to analyze the mRNA and protein expression, respectively; cell viability was assayed with MTS analysis; cell migration was measured with Trans-well analysis. Key findings: In the present study, the results indicated that the mRNA levels of LSD1 and TSPAN8 in CRC were significantly higher than that in corresponding adjacent non-tumor tissue. Down-regulation of LSD1 or TSPAN8 as well as LSD1 inhibitor Tranylcypromine hemisulfate inhibited the proliferation and migration of CRC cells, while over-expression of LSD1 exhibited opposite effects. LSD1 up-regulated TSPAN8 expression and reduced H3K9me2 occupancy on the TSPAN8 promoter in CRC cells. TSPAN8 promoted epithelial-mesenchymal transition (EMT) in CRC cells in LSD1-dependent manner. Significance: TSPAN8 may be considered as a promising biomarker for the diagnosis and prognosis in patients with CRC. Furthermore, TSPAN8 could be a novel therapeutic target and potent LSD1 inhibitors could be designed and developed in the treatment of CRC.
Keyword ：
TSPAN8 TSPAN8 Colorectal cancer Colorectal cancer LSD1 LSD1 EMT EMT H3K9me2 H3K9me2
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| GB/T 7714 | Zhang, Hong-Sheng , Liu, Hui-Yun , Zhou, Zhen et al. TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner [J]. | LIFE SCIENCES , 2020 , 241 . |
| MLA | Zhang, Hong-Sheng et al. "TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner" . | LIFE SCIENCES 241 (2020) . |
| APA | Zhang, Hong-Sheng , Liu, Hui-Yun , Zhou, Zhen , Sun, Hong-Liang , Liu, Min-Yao . TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner . | LIFE SCIENCES , 2020 , 241 . |
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