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学者姓名：张红胜
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Abstract ：
Amino acids act as versatile nutrients driving cell growth and survival, especially in cancer cells. Amino acid metabolism comprises numerous metabolic networks and is closely linked with intracellular redox balance and epigenetic regulation. Reprogrammed amino acid metabolism has been recognized as a ubiquitous feature in tumour cells. This review outlines the metabolism of several primary amino acids in cancer cells and highlights the pivotal role of amino acid metabolism in sustaining redox homeostasis and regulating epigenetic modification in response to oxidative and genetic stress in cancer cells.
Keyword ：
epigenetic regulation epigenetic regulation cancer cancer redox balance redox balance amino acids amino acids metabolism metabolism
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| GB/T 7714 | Li, Xiang , Zhang, Hong-Sheng . Amino acid metabolism, redox balance and epigenetic regulation in cancer [J]. | FEBS JOURNAL , 2023 , 291 (3) : 412-429 . |
| MLA | Li, Xiang 等. "Amino acid metabolism, redox balance and epigenetic regulation in cancer" . | FEBS JOURNAL 291 . 3 (2023) : 412-429 . |
| APA | Li, Xiang , Zhang, Hong-Sheng . Amino acid metabolism, redox balance and epigenetic regulation in cancer . | FEBS JOURNAL , 2023 , 291 (3) , 412-429 . |
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Abstract ：
Breast cancer has become the first rank cancer in the world,and the exploration of the pathogenesisand treatment of breast cancer deserves more and more attention.Lipid metabolism dysfunction is one of the mostprominent metabolic changes in cancer cells.It is very important to explore the changes of lipid metabolism inbreast cancer cells in order to find new diagnostic indicators and therapeutic targets.This paper introduces theresearch progress of lipid metabolism dysfunction in breast cancer from4aspects:(1)the expression of abnormalfatty acid metabolism in breast cancer from three aspects of fatty acid synthesis,oxidation and uptake and therelated research progress;(2)introduction to the abnormal expression of triglyceride metabolism in breast cancerfrom the aspects of triglyceride synthesis and degradation and the related research progress;(3)to introduce theabnormal expression of cholesterol synthase in breast cancer and the related research progress;(4)to introducethe abnormal expression of lipid metabolism signaling pathways in breast cancer from five signaling pathways,namely Notch,Hippo,Hedgehog,Wnt and mTOR,and the related research progress.The aim is to provide newideas and methods for targeting lipid metabolism in the treatment of breast cancer
Keyword ：
lipid metabolism lipid metabolism triglyceride metabolism triglyceride metabolism fatty acid metabolism fatty acid metabolism breast cancer breast cancer cholesterol metabolism cholesterol metabolism
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| GB/T 7714 | Wang Miao , Wang Xin-Yu , Li Hong-Ming et al. The Progress of Lipid Metabolism in Breast Cancer br [J]. | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2022 , 49 (6) : 1052-1060 . |
| MLA | Wang Miao et al. "The Progress of Lipid Metabolism in Breast Cancer br" . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 49 . 6 (2022) : 1052-1060 . |
| APA | Wang Miao , Wang Xin-Yu , Li Hong-Ming , Zhang Hong-Sheng . The Progress of Lipid Metabolism in Breast Cancer br . | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS , 2022 , 49 (6) , 1052-1060 . |
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Abstract ：
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and major cause of cancer death in the world. Ferroptosis is a recently identified type of regulated cell death. Increasing evidence has shown that ferroptosis plays an important regulatory role in the occurrence and development of cancer. This study identified TIGAR as a potential regulator of ferroptosis resistance in the development of CRC. We showed that TIGAR expression in CRC tissues is significantly higher than that in adjacent normal tissues. Knockdown of TIGAR significantly caused an increase in erastin-induced ferroptosis in SW620 and HCT116 cells. Notably, knockdown of TIGAR significantly decreased GSH/GSSG ratio, increased lipid peroxidation production, and facilitated the accumulation of lipid peroxidation product malondialdehyde (MDA), and rendered CRC cells more sensitive to erastin induced ferroptosis. Furthermore, TIGAR inhibition repressed SCD1 expression in a redox and AMPK-dependent manner. Thus, these results suggest that TIGAR induces ferroptosis resistance in CRC cells via the ROS/AMPK/SCD1 signaling pathway.
Keyword ：
TIGAR TIGAR AMPK AMPK Ferroptosis Ferroptosis SCD1 SCD1 Redox Redox
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| GB/T 7714 | Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway [J]. | FREE RADICAL BIOLOGY AND MEDICINE , 2022 , 182 : 219-231 . |
| MLA | Liu, Min-Yao et al. "TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway" . | FREE RADICAL BIOLOGY AND MEDICINE 182 (2022) : 219-231 . |
| APA | Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Xia, Ran , Li, Xiang , Ma, Yu-Jie et al. TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/ SCD1 pathway . | FREE RADICAL BIOLOGY AND MEDICINE , 2022 , 182 , 219-231 . |
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Abstract ：
课程思政是新时期高校教育新模式.如何充分发掘医学基础专业基础课程蕴含的课程思政元素,将其融入教学实践过程中,对实现三全育人,引导学生建立正确的人生观、价值观及职业观,具有重要的现实意义.通过对医学基础的课程思政元素和教案设计进行探索与实践,设计医学基础课程思政的切入点、思路.通过教学实践与教学反思,准确地把握思想政治教育的时机与方法.主要探索课程思政与医学基础课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
Keyword ：
医学基础 医学基础 思想政治教育 思想政治教育 三全育人 三全育人
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| GB/T 7714 | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 [J]. | 教育教学论坛 , 2021 , (38) : 58-61 . |
| MLA | 张红胜 et al. "研究生医学基础课程思政教学的探索与实践" . | 教育教学论坛 38 (2021) : 58-61 . |
| APA | 张红胜 , 王明连 . 研究生医学基础课程思政教学的探索与实践 . | 教育教学论坛 , 2021 , (38) , 58-61 . |
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Abstract ：
如何充分发掘药理学专业基础课程所蕴含的课程思政元素,将其融入日常教学,对实现三全育人,引导当代大学生建立正确人生观、价值观及职业观,具有重要的现实意义.本文主要从探索课程思政与药理学专业课程的有效融合教学范式,发挥立德树人和三全育人的重要作用.
Keyword ：
三全育人 三全育人 课程思政 课程思政 多元式教学 多元式教学
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| GB/T 7714 | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 [J]. | 产业与科技论坛 , 2021 , 20 (10) : 153-154 . |
| MLA | 张红胜 . "学科历史与学科前沿融入药理学课程思政的探索与实践" . | 产业与科技论坛 20 . 10 (2021) : 153-154 . |
| APA | 张红胜 . 学科历史与学科前沿融入药理学课程思政的探索与实践 . | 产业与科技论坛 , 2021 , 20 (10) , 153-154 . |
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Abstract ：
线上线下混合式教学成为实现大学教育教学新形态。结合药理学线上教学与传统线下课堂教学的特点,探讨了基于慕课异步SPOC课程的特点及其与传统教学模式相融合的混合式教学模式的探索,包括教学平台的选择、教学的组织和特点、教学的考核等,分析了线上线下混合式教学模式的新特点,旨在促进线上教学与传统教学在药理学课堂中的应用,为传统教学提供了新的活力。
Keyword ：
药理学 药理学 课程思政 课程思政 慕课 慕课 线上线下混合式教学 线上线下混合式教学
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| GB/T 7714 | 张红胜 . 药理学线上线下混合式教学的思考与实践 [J]. | 科技资讯 , 2021 , 19 (05) : 155-158 . |
| MLA | 张红胜 . "药理学线上线下混合式教学的思考与实践" . | 科技资讯 19 . 05 (2021) : 155-158 . |
| APA | 张红胜 . 药理学线上线下混合式教学的思考与实践 . | 科技资讯 , 2021 , 19 (05) , 155-158 . |
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Abstract ：
Cancer cells can metabolize glutamine to replenish TCA cycle intermediates for cell survival. Glutaminase (GLS1) is over-expressed in multiple cancers, including colorectal cancer (CRC). However, the role of GLS1 in colorectal cancer development has not yet fully elucidated. In this study, we found that GLS1 levels were significantly increased in CRC cells. Knockdown of GLS1 by shRNAs as well as GLS1 inhibitor BPTES decreased DLD1 and SW480 cell proliferation, colony formation and migration. Knockdown of GLS1 as well as BPTES induced reactive oxygen species (ROS) production, down-regulation of GSH/GSSG ratio, an decrease in Nrf2 protein expression and an increase in cytoplasmic Nrf2 protein expression in DLD1 and SW480 cells. Furthermore, Knockdown of GLS1 as well as BPTES inhibited autophagy pathway, antioxidant NAC and Nrf2 activator could reversed inhibition of GLS1-mediated an decrease in autophagic flux in DLD1 and SW480 cells. Depletion of GLS1-induced inhibition of DLD1 and SW480 CRC cell proliferation, colony formation and migration was reversed by autophagy inducer rapamycin. These results suggest that targeting GLS1 might be a new potential therapeutic target for the treatment of CRC.
Keyword ：
GLS1 GLS1 Redox Redox Autophagy Autophagy Colorectal cancer Colorectal cancer
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| GB/T 7714 | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao et al. GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway [J]. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
| MLA | Liu, Hui-Yun et al. "GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway" . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 708 (2021) . |
| APA | Liu, Hui-Yun , Zhang, Hong-Sheng , Liu, Min-Yao , Li, Hong-Ming , Wang, Xin-Yu , Wang, Miao . GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway . | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , 2021 , 708 . |
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Abstract ：
药理学线上线下混合式教学的思考与实践
Keyword ：
线上线下混合式教学 线上线下混合式教学 慕课 慕课 课程思政 课程思政 药理学 药理学
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| GB/T 7714 | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 [J]. | 张红胜 , 2021 , 19 (5) : 155-158 . |
| MLA | 张红胜 et al. "药理学线上线下混合式教学的思考与实践" . | 张红胜 19 . 5 (2021) : 155-158 . |
| APA | 张红胜 , 科技资讯 . 药理学线上线下混合式教学的思考与实践 . | 张红胜 , 2021 , 19 (5) , 155-158 . |
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Abstract ：
The COVID-19 pandemic has severely affected various aspects of life, at different levels and in different countries on almost every continent. In response, many countries have closed their borders and imposed lockdown policies, possibly bringing benefits to people's health with significantly less emission from air pollutants. Currently, most studies or reports are based on local observations at the city or country level. There remains a lack of systematic understanding of the impacts of different lockdown policies on the air quality from a global perspective. This study investigates the impacts of COVID-19 pandemic towards global air quality through examining global nitrogen dioxide (NO2) dynamics from satellite observations between 1 January and 30 April 2020. We used the Apriori algorithm, an unsupervised machine learning method, to investigate the association among confirmed cases of COVID-19, NO2 column density, and the lockdown policies in 187 countries. The findings based on weekly data revealed that countries with new cases adopted various lockdown policies to stop or prevent the virus from spreading whereas those without tended to adopt a wait-and-see attitude without enforcing lockdown policies. Interestingly, decreasing NO2 concentration due to lockdown was associated with international travel controls but not with public transport closure. Increasing NO2 concentration was associated with the "business as usual" strategy as evident from North America and Europe during the early days of COVID-19 outbreak (late January to early February 2020), as well as in recent days (in late April) after many countries have started to resume economic activities. This study enriches our understanding of the heterogeneous patterns of global associations among the COVID-19 spreading, lockdown policies and their environmental impacts on NO2 dynamics.
Keyword ：
Apriori Apriori Coronavirus Coronavirus COVID-19 COVID-19 NO(2) NO(2) Association rules Association rules Lockdown policies Lockdown policies
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| GB/T 7714 | Zhang Hongsheng , Lin Yinyi , Wei Shan et al. Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic. [J]. | The Science of the total environment , 2021 , 761 : 144148 . |
| MLA | Zhang Hongsheng et al. "Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic." . | The Science of the total environment 761 (2021) : 144148 . |
| APA | Zhang Hongsheng , Lin Yinyi , Wei Shan , Loo Becky P Y , Lai P C , Lam Yun Fat et al. Global association between satellite-derived nitrogen dioxide (NO2) and lockdown policies under the COVID-19 pandemic. . | The Science of the total environment , 2021 , 761 , 144148 . |
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Abstract ：
Road datasets are fundamental and imperative for traffic management and urban planning. Different high resolution optical remote sensing images are widely used for automatic road extraction but the results are usually limited to local scale and spectral confusions in barren and cropland, while accurate large-scale road extraction remains challenging. In this study, we incorporated medium resolution optical and SAR data, i.e., 10 meter resolution Sentinel-1 and Sentinel-2, for road extraction at a large scale and evaluated the contribution of different data sources. We developed a United U-Net (UU-Net) to fuse optical and SAR data for road extraction, which was trained and evaluated on a large-scale multisource road extraction dataset. The UU-Net achieved better accuracy than traditional deep convolutional networks with optical or SAR data alone, which obtained an average F1 of 0.5502 and an average IoU of 0.4021, outperforming in 160 out of 200 (80%) 0.5-by-0.5 degree evaluation grids. The results indicated that SAR contributes more to road extraction in barren land, while optical data contributes more to large slope areas. The road accuracy is positively related to elevation and urban percentage, which distributes higher in eastern China and lower in western. The road centerline from 10 m road showed comparable results with that from Open Street Map (OSM), indicating its promising applications to support large-scale urban transportation studies.
Keyword ：
U-Net U-Net SAR SAR OSM OSM Road Road Optical Optical
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| GB/T 7714 | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction [J]. | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
| MLA | Lin, Yinyi et al. "Leveraging optical and SAR data with a UU-Net for large-scale road extraction" . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION 103 (2021) . |
| APA | Lin, Yinyi , Wan, Luoma , Zhang, Hongsheng , Wei, Shan , Ma, Peifeng , Li, Yu et al. Leveraging optical and SAR data with a UU-Net for large-scale road extraction . | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION , 2021 , 103 . |
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