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学者姓名：刘博
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Abstract ：
针对服务计算、物联网、云计算、服务互联网、工业互联网、数字智慧服务等新兴产业对具有原始创新能力的软件设计人才需求，探讨如何围绕软件设计核心价值体系进行本科软件设计与体系结构课程内容建设及实践环节创新，提出以“知识型工程创新设计(KEID)”为核心价值的课程知识体系结构并介绍以开放式领域建模为基础的创新性实践环节设计。
Keyword ：
软件体系结构 软件体系结构 KIIC实践环节设计 KIIC实践环节设计 知识型工程创新设计(KEID) 知识型工程创新设计(KEID) 开放式领域建模 开放式领域建模
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| GB/T 7714 | 张建 , 刘博 , 朱青 et al. 软件设计与体系结构课程内容建设及创新探索 [J]. | 计算机教育 , 2022 , PageCount-页数: 5 (07) : 62-66 . |
| MLA | 张建 et al. "软件设计与体系结构课程内容建设及创新探索" . | 计算机教育 PageCount-页数: 5 . 07 (2022) : 62-66 . |
| APA | 张建 , 刘博 , 朱青 , 张丽 . 软件设计与体系结构课程内容建设及创新探索 . | 计算机教育 , 2022 , PageCount-页数: 5 (07) , 62-66 . |
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| GB/T 7714 | Liu, Bo , Ji, Xinchan , Li, Jinmeng et al. Integrative analysis identifies three molecular subsets in ovarian cancer [J]. | CLINICAL AND TRANSLATIONAL MEDICINE , 2022 , 12 (9) . |
| MLA | Liu, Bo et al. "Integrative analysis identifies three molecular subsets in ovarian cancer" . | CLINICAL AND TRANSLATIONAL MEDICINE 12 . 9 (2022) . |
| APA | Liu, Bo , Ji, Xinchan , Li, Jinmeng , Zhu, Nian , Long, Junqi , Zhuang, Xujie et al. Integrative analysis identifies three molecular subsets in ovarian cancer . | CLINICAL AND TRANSLATIONAL MEDICINE , 2022 , 12 (9) . |
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Abstract ：
本发明公开了基于节点级嵌入特征三维关系重建的图数据相似度方法，属于深度学习领域，首先通过孪生图卷积层和相似节点交互模块生成节点级嵌入特征三维关系，然后将节点级嵌入特征三维关系经过三维卷积提取特征，将三维特征经过Flatten层展开为一维，获得最终节点级关系向量。这一关系向量输入到由全连接层构成的结果输出模块得到预测输出。这一预测输出与实际的标签值进行比较，通过损失函数和反向传播算法对整体模型参数进行更新以达到学习的目的。完成训练的DeepSIM‑3D模型能高效可靠地计算输入的两个图结构数据的相似度。
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| GB/T 7714 | 刘博 , 武嘉慧 , 王志晗 et al. 基于节点级嵌入特征三维关系重建的图数据相似度方法 : CN202210059012.6[P]. | 2022-01-18 . |
| MLA | 刘博 et al. "基于节点级嵌入特征三维关系重建的图数据相似度方法" : CN202210059012.6. | 2022-01-18 . |
| APA | 刘博 , 武嘉慧 , 王志晗 , 张冀东 . 基于节点级嵌入特征三维关系重建的图数据相似度方法 : CN202210059012.6. | 2022-01-18 . |
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Abstract ：
Background. Currently, predictive models were not developed based on the signaling pathway signatures of immune-related lncRNAs in breast cancer (BRCA) patients. Methods. We selected unsupervised hierarchical clustering algorithm to classify patients with BRCA based on the significant immune-derived lncRNAs from the TCGA dataset. And different methods including ESTIMATE, ImmuneCellAI, and CIBERSORT were performed to evaluate the immune infiltration of tumor microenvironment. Using Lasso regression algorithm, we filtered the significant signaling pathways enriched by GSEA, GSVA, or PPI analysis to develop a prognostic model. And a nomogram integrated with clinical factors and significant pathways was constructed to predict the precise probability of overall survival (OS) of BRCA patients in the TCGA dataset (n =1,098) and another two testing sets (n = 415). Results. BRCA patients were stratified into the PC (n = 571) and GC (n = 527) subgroup with significantly different prognosis with 550 immune-related lncRNAs in the TCGA dataset. Integrated analysis revealed different immune response, oncogenic signaling, and metabolic reprograming pathways between these two subgroups. And a 5-pathway signature could predict the prognosis of BRCA patients between these two subgroups independently in the TCGA dataset, which was confirmed in another two cohorts from the GEO dataset. In the TCGA dataset, 5-year OS rate was 78% (95% CI: 73-84) vs. 82% (95% CI: 77-87) for the PC and GC group (HR = 1.63 (95% CI: 1.17-2.28), p 0.004). The predictive power was similar in another two testing sets (HR > 1.20, p < 0.01). Finally, a nomogram is developed for clinical application, which integrated this signature and age to accurately predict the survival probability in BRCA patients. Conclusion. This 5-pathway signature correlated with immune derived lncRNAs was able to precisely predict the prognosis for patients with BRCA and provided a rich source characterizing immune-related lncRNAs and further informed strategies to target BRCA vulnerabilities.
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| GB/T 7714 | Liu, Bo , Zhu, Nian , Huo, Huixia et al. A 5-Pathway Signature Predicts Prognosis Based on Immune-Derived lncRNAs in Patients with Breast Cancer [J]. | JOURNAL OF ONCOLOGY , 2022 , 2022 . |
| MLA | Liu, Bo et al. "A 5-Pathway Signature Predicts Prognosis Based on Immune-Derived lncRNAs in Patients with Breast Cancer" . | JOURNAL OF ONCOLOGY 2022 (2022) . |
| APA | Liu, Bo , Zhu, Nian , Huo, Huixia , Long, Junqi , Ji, Xinchan , Li, Jinmeng et al. A 5-Pathway Signature Predicts Prognosis Based on Immune-Derived lncRNAs in Patients with Breast Cancer . | JOURNAL OF ONCOLOGY , 2022 , 2022 . |
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Abstract ：
With the continuous development of bioinformatics, traditionally biological sequence analysis methods are insufficient to deal with the increasingly complex and huge biological data. In the face of this situation, deep learning has been gradually applied in biological analysis and made a series of progresses, which has become a hot research topic in biological data analysis with its advantages in processing high-dimensional data. The current research status was reviewed to better understand the new development of deep learning in the field of bioinformatics data analysis. First, the importance of applying deep learning were introduced. Second, representative deep learning models in the current application fields was described. Then, the application research status of deep learning in this field was analyzed. Finally, current limitations of deep learning in the bioinformatics field and the factors that should be considered in future development were illustrated in this paper. © 2022, Editorial Department of Journal of Beijing University of Technology. All right reserved.
Keyword ：
Bioinformatics; Biological sequences analysis; Deep learning; Gene; Nucleic acid; Protein Bioinformatics; Biological sequences analysis; Deep learning; Gene; Nucleic acid; Protein
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| GB/T 7714 | Zhang, J. , Wang, Z. , Liu, B. . Progress in the Applications of Deep Learning in Biological Sequences Analysis [深度学习在生物序列分析领域的应用进展] [J]. | Journal of Beijing University of Technology , 2022 , 48 (8) : 878-887 . |
| MLA | Zhang, J. et al. "Progress in the Applications of Deep Learning in Biological Sequences Analysis [深度学习在生物序列分析领域的应用进展]" . | Journal of Beijing University of Technology 48 . 8 (2022) : 878-887 . |
| APA | Zhang, J. , Wang, Z. , Liu, B. . Progress in the Applications of Deep Learning in Biological Sequences Analysis [深度学习在生物序列分析领域的应用进展] . | Journal of Beijing University of Technology , 2022 , 48 (8) , 878-887 . |
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Abstract ：
Upper limb kinematic analysis that has been employed in the clinical assessment of motion functions or rehabilitation training is traditionally tested manually with a goniometer. Nowadays, it is a trend to deploy different technology and devices including low-cost but accurate RGB cameras in order to save manual efforts. Among these, a new method using deep learning-based cameras has been investigated to provide the same ease and accessibility as a manual handheld goniometer. The key to measuring upper limb Range of Motion (ROM) using a camera is to estimate upper limb joints accurately. Many existing joint estimation algorithms focus on improving the accuracy performance but put the efficiency concerns aside. It is still challenging to apply those algorithms to low-capacity and budget-friendly devices, which is highly demanding in clinical scenarios. We propose a lightweight and fast deep learning model to estimate human pose and then use predicted joints to measure the range of motion for upper limb joints. Unlike other human pose estimation methods that learn and predict all major joints of the human body, the proposed model only focuses on the upper limb, which improves the accuracy and reduces the overhead of prediction. To further reduce model size and latency, our model is based on a compact neural network architecture, and parameters in the network are quantized to 8-bit precision. As a result, our model runs 4.1 times faster and is 15.5 times smaller compared with a full sized state of the art human pose estimation model. The proposed method is further evaluated on different upper limb functional tasks. Results show that our new method achieves a satisfying accuracy in ROM measurement and a high degree of agreement with a goniometer. Compared with the goniometer to measure ROM, our presented method is easier to operate and can be performed remotely, while still retaining good accuracy.
Keyword ：
2D body estimate 2D body estimate low-capacity device low-capacity device range of motion range of motion quantized convolutional neural network quantized convolutional neural network deep learning deep learning
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| GB/T 7714 | Yan, Xuke , Zhang, Linxi , Liu, Bo et al. A Lightweight and Fast Approach for Upper Limb Range of Motion Assessment [J]. | 2022 21ST IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS, ICMLA , 2022 : 53-60 . |
| MLA | Yan, Xuke et al. "A Lightweight and Fast Approach for Upper Limb Range of Motion Assessment" . | 2022 21ST IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS, ICMLA (2022) : 53-60 . |
| APA | Yan, Xuke , Zhang, Linxi , Liu, Bo , Qu, Guangzhi . A Lightweight and Fast Approach for Upper Limb Range of Motion Assessment . | 2022 21ST IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS, ICMLA , 2022 , 53-60 . |
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Abstract ：
As an important method to diagnose gastric cancer, gastric pathological sections images (GPSI) are hard and time-consuming to be recognized even by an experienced doctor. An efficient method was designed to detect gastric cancer in magnified (20x) GPSI using deep learning technology. A novel DenseNet architecture was applied, modified with a multistage attention module (MSA-DenseNet). To develop this model focusing on gastric features, a two-stage-input attention module was adopted to select more semantic information of cancer. Moreover, the pretraining process was divided into two steps to improve the effect of the attention mechanism. After training, our method achieved a state-of-the-art performance yielding 0.9947 F1 score and 0.9976 ROC AUC on a test dataset. In line with our expectation in clinical practice, a high recall (0.9929) was produced with high sensitivity to the positive samples. These results indicate that this new model performs better than current artificial detection approaches and its effectiveness is therefore validated in cancer pathological diagnoses.
Keyword ：
computer‐ computer‐ assisted diagnosis assisted diagnosis gastric pathological sections gastric pathological sections gastric cancer gastric cancer deep learning deep learning
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| GB/T 7714 | Liu, Bo , Zhao, Yelong , Yang, Bin et al. A gastric cancer recognition algorithm on gastric pathological sections based on multistage attention-DenseNet [J]. | CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE , 2021 , 33 (10) . |
| MLA | Liu, Bo et al. "A gastric cancer recognition algorithm on gastric pathological sections based on multistage attention-DenseNet" . | CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE 33 . 10 (2021) . |
| APA | Liu, Bo , Zhao, Yelong , Yang, Bin , Zhao, Shuangtao , Gu, Rentao , Gahegan, Mark . A gastric cancer recognition algorithm on gastric pathological sections based on multistage attention-DenseNet . | CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE , 2021 , 33 (10) . |
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Abstract ：
大气污染领域本体的半自动构建及语义推理
Keyword ：
语义推理 语义推理 注意力机制 注意力机制 大气污染 大气污染 自然语言处理 自然语言处理 实体关系抽取 实体关系抽取 本体 本体
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| GB/T 7714 | 刘博 , 张佳慧 , 李建强 et al. 大气污染领域本体的半自动构建及语义推理 [J]. | 刘博 , 2021 , 47 (3) : 246-259 . |
| MLA | 刘博 et al. "大气污染领域本体的半自动构建及语义推理" . | 刘博 47 . 3 (2021) : 246-259 . |
| APA | 刘博 , 张佳慧 , 李建强 , 李永 , 郎建垒 , 北京工业大学学报 . 大气污染领域本体的半自动构建及语义推理 . | 刘博 , 2021 , 47 (3) , 246-259 . |
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Abstract ：
Atmospheric visibility is an indicator of atmospheric transparency and its range directly reflects the quality of the atmospheric environment. With the acceleration of industrialization and urbanization, the natural environment has suffered some damages. In recent decades, the level of atmospheric visibility shows an overall downward trend. A decrease in atmospheric visibility will lead to a higher frequency of haze, which will seriously affect people's normal life, and also have a significant negative economic impact. The causal relationship mining of atmospheric visibility can reveal the potential relation between visibility and other influencing factors, which is very important in environmental management, air pollution control and haze control. However, causality mining based on statistical methods and traditional machine learning techniques usually achieve qualitative results that are hard to measure the degree of causality accurately. This article proposed the seq2seq-LSTM Granger causality analysis method for mining the causality relationship between atmospheric visibility and its influencing factors. In the experimental part, by comparing with methods such as linear regression, random forest, gradient boosting decision tree, light gradient boosting machine, and extreme gradient boosting, it turns out that the visibility prediction accuracy based on the seq2seq-LSTM model is about 10% higher than traditional machine learning methods. Therefore, the causal relationship mining based on this method can deeply reveal the implicit relationship between them and provide theoretical support for air pollution control.
Keyword ：
granger causality granger causality deep learning deep learning multidimensional time series multidimensional time series Atmospheric visibility Atmospheric visibility
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| GB/T 7714 | Liu, Bo , He, Xi , Song, Mingdong et al. A Method for Mining Granger Causality Relationship on Atmospheric Visibility [J]. | ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA , 2021 , 15 (5) . |
| MLA | Liu, Bo et al. "A Method for Mining Granger Causality Relationship on Atmospheric Visibility" . | ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA 15 . 5 (2021) . |
| APA | Liu, Bo , He, Xi , Song, Mingdong , Li, Jiangqiang , Qu, Guangzhi , Lang, Jianlei et al. A Method for Mining Granger Causality Relationship on Atmospheric Visibility . | ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA , 2021 , 15 (5) . |
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Abstract ：
本实验对3组同规格SBR反应器分别采用分阶段法(A/O-A/O/A)异步驯化、连续曝气A/OA同步驯化和间歇曝气A/O/A同步驯化的方式运行.以人工配水为进水基质,接种絮状污泥,通过水力选择压颗粒化,探讨了不同运行方式下短程硝化反硝化颗粒污泥的驯化及脱氮除磷特性.结果表明,在较短曝气时长(140 min)联合较低曝气强度[3.5 L·(h·L)~(-1)]下,间歇曝气A/O/A同步驯化最具优势,后期稳定运行期间碳、氮、磷的平均去除率分别为90.74%、91.15%和95.66%,可实现同步去除.粒径为895μm,颗粒虽小但均匀致密,f值(MLVSS/MLSS)平稳保持在0.8～0.85,有较高...
Keyword ：
曝气时长 曝气时长 颗粒污泥 颗粒污泥 间歇曝气 间歇曝气 曝气强度 曝气强度 短程硝化反硝化除磷 短程硝化反硝化除磷 同步驯化 同步驯化
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| GB/T 7714 | 王文琪 , 李冬 , 高鑫 et al. 短程硝化反硝化除磷颗粒污泥的同步驯化 [J]. | 环境科学 , 2021 , 42 (06) : 2946-2956 . |
| MLA | 王文琪 et al. "短程硝化反硝化除磷颗粒污泥的同步驯化" . | 环境科学 42 . 06 (2021) : 2946-2956 . |
| APA | 王文琪 , 李冬 , 高鑫 , 刘博 , 张杰 . 短程硝化反硝化除磷颗粒污泥的同步驯化 . | 环境科学 , 2021 , 42 (06) , 2946-2956 . |
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