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学者姓名：乔爱科
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Abstract ：
A key strategy for increasing drug mass (DM) while maintaining good safety is to improve the drug release profile (RP). We designed a dual layer coating drug-eluting stent (DES) that exhibited smaller concentration gradients between the coating and the artery wall and significantly impacted the drug RP. However, a detailed understanding of the effects of the DES designed by our team on safety and efficacy is still lacking. The objective of this study was to provide a comprehensive multiscale computational framework that would allow us to probe the safety and efficacy of the DES we designed. This framework consisted of four coupled modules, namely (1) a mechanical stimuli module, simulating mechanical stimuli caused by percutaneous coronary intervention through a finite element analysis, (2) an inflammation module, simulating inflammation of vascular smooth muscle cells (VSMCs) induced by mechanical stimuli through an agent-based model (ABM), (3) a drug transport module, simulating drug transport through a continuum-based approach, and (4) a mitosis module, simulating VSMC mitosis through an ABM. Our results indicated that when the DM increased to two times the initial DM value, the DES we designed had higher safety and lower efficacy values than a conventional DES. When the DM increased to five times the initial DM value, the DES we designed had higher safety than a conventional DES, and negligible differences in efficacy compared with a conventional DES. In summary, the DES we designed exhibited a significant advantage in safety, but a slightly reduced efficacy compared with that of a conventional DES.
Keyword ：
Efficacy Efficacy Agent-based model Agent-based model Drug-eluting stent Drug-eluting stent Safety Safety
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| GB/T 7714 | Guo, Bao , Chen, Shiliang , Zhang, Yu et al. A quantitative study of the effects of a dual layer coating drug-eluting stent on safety and efficacy [J]. | JOURNAL OF BIOMECHANICS , 2024 , 176 . |
| MLA | Guo, Bao et al. "A quantitative study of the effects of a dual layer coating drug-eluting stent on safety and efficacy" . | JOURNAL OF BIOMECHANICS 176 (2024) . |
| APA | Guo, Bao , Chen, Shiliang , Zhang, Yu , Yang, Yujia , Song, Hongfang , Zhang, Yanping et al. A quantitative study of the effects of a dual layer coating drug-eluting stent on safety and efficacy . | JOURNAL OF BIOMECHANICS , 2024 , 176 . |
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Abstract ：
Current research on the fatigue properties of degradable zinc alloy stents has not yet considered the issue of the fatigue life changing with material properties during the dynamic degradation process. Therefore, in this paper, we established a fatigue damage algorithm to study the fatigue problem affected by the changing of material properties during the dynamic degradation process of the stent under the action of pulsating cyclic loading. Three models: the dynamic degradation model, the dynamic degradation model under pulsating cyclic loading, and the coupled model of fatigue damage and dynamic degradation, were developed to verify the effect of fatigue damage on stent life. The results show that fatigue damage leads to a deeper degree of inhomogeneous degradation of the stent, which affects the service life of the stent. Fatigue damage is a factor that cannot be ignored. Therefore, when studying the mechanical properties and lifetime of degradable stents, incorporating fatigue damage into the study can help more accurately assess the lifetime of the stents.
Keyword ：
dynamic degradation dynamic degradation pulsating cyclic loading pulsating cyclic loading degradable zinc alloy stents degradable zinc alloy stents fatigue damage fatigue damage
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| GB/T 7714 | Qi, Jing , Zhang, Hanbing , Chen, Shiliang et al. Numerical Simulation of Dynamic Degradation and Fatigue Damage of Degradable Zinc Alloy Stents [J]. | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2023 , 14 (11) . |
| MLA | Qi, Jing et al. "Numerical Simulation of Dynamic Degradation and Fatigue Damage of Degradable Zinc Alloy Stents" . | JOURNAL OF FUNCTIONAL BIOMATERIALS 14 . 11 (2023) . |
| APA | Qi, Jing , Zhang, Hanbing , Chen, Shiliang , Du, Tianming , Zhang, Yanping , Qiao, Aike . Numerical Simulation of Dynamic Degradation and Fatigue Damage of Degradable Zinc Alloy Stents . | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2023 , 14 (11) . |
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| GB/T 7714 | Qiao, Aike , Du, Tianming , Yang, Haisheng et al. Biomechanical Study and Analysis for Cardiovascular/Skeletal Materials and Devices [J]. | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2023 , 14 (8) . |
| MLA | Qiao, Aike et al. "Biomechanical Study and Analysis for Cardiovascular/Skeletal Materials and Devices" . | JOURNAL OF FUNCTIONAL BIOMATERIALS 14 . 8 (2023) . |
| APA | Qiao, Aike , Du, Tianming , Yang, Haisheng , Mu, Yongliang . Biomechanical Study and Analysis for Cardiovascular/Skeletal Materials and Devices . | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2023 , 14 (8) . |
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Abstract ：
目的:使用计算流体力学研究单层或双层裸金属支架治疗冠状动脉瘤(冠脉瘤)的新方法.方法:选取5例瘤体直径不同的冠脉瘤患者,分别置入单层或双层裸金属支架治疗,使用计算流体力学方法构建冠脉瘤模型并模拟单、双层裸金属支架置入过程,分析裸金属支架置入后冠脉瘤内血液动力学参数的变化.结果:在模型1(病例1,瘤体直径4 mm)中,相比无支架状态和双层裸金属支架状态,单层裸金属支架状态时血流速度最低.在模型2至模型5(病例2～病例5)中(瘤体直径6.5～16.0 mm),相比无支架状态和单层裸金属支架状态,双层裸金属支架状态的血流速度最低.在模型1和模型2中,随着裸金属支架依次模拟置入,冠脉瘤壁面压力和切应力呈现出下降趋势.模型3、4和5则表现出随着裸金属支架的依次模拟置入,冠脉瘤壁面压力逐渐上升,切应力则呈现出个体化变化.随访发现5例冠脉瘤均成功封闭且无明显支架内再狭窄.结论:瘤体直径<6.5 mm的冠脉瘤可采用单层裸金属支架覆盖瘤颈,瘤体直径在6.5～16.0 mm之间的冠脉瘤建议采用双层裸金属支架覆盖瘤颈.该技术可有效改变冠脉瘤内血流速度及载瘤动脉血流导向,促进瘤体愈合.
Keyword ：
计算流体力学 计算流体力学 冠状动脉瘤 冠状动脉瘤 裸金属支架 裸金属支架 经皮冠状动脉介入治疗 经皮冠状动脉介入治疗
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| GB/T 7714 | 杨卓璇 , 袁建松 , 崔锦钢 et al. 单层或双层裸金属支架治疗冠状动脉瘤的流体力学分析 [J]. | 中国循环杂志 , 2023 , 38 (3) : 318-325 . |
| MLA | 杨卓璇 et al. "单层或双层裸金属支架治疗冠状动脉瘤的流体力学分析" . | 中国循环杂志 38 . 3 (2023) : 318-325 . |
| APA | 杨卓璇 , 袁建松 , 崔锦钢 , 付文宇 , 乔爱科 , 周越 et al. 单层或双层裸金属支架治疗冠状动脉瘤的流体力学分析 . | 中国循环杂志 , 2023 , 38 (3) , 318-325 . |
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Abstract ：
Biodegradable stents can support vessels for an extended period, maintain vascular patency, and progressively degrade once vascular remodeling is completed, thereby reducing the constraints of traditional metal stents. An ideal degradable stent must have good mechanical properties, degradation behavior, and biocompatibility. Zinc has become a new type of biodegradable metal after magnesium and iron, owing to its suitable degradation rate and good biocompatibility. However, zinc's poor strength and ductility make it unsuitable as a vascular stent material. Therefore, this paper reviewed the primary methods for improving the overall properties of zinc. By discussing the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies, we found that alloying is the most common, simple, and effective method to improve mechanical properties. Deformation processing can further improve the mechanical properties by changing the microstructures of zinc alloys. Surface modification is an important means to improve the biological activity, blood compatibility and corrosion resistance of zinc alloys. Meanwhile, structural design can not only improve the mechanical properties of the vascular stents, but also endow the stents with special properties such as negative Poisson 's ratio. Manufacturing zinc alloys with excellent degradation properties, improved mechanical properties and strong biocompatibility and exploring their mechanism of interaction with the human body remain areas for future research.
Keyword ：
Vascular remodeling Vascular remodeling Ideal biodegradable vascular stents Ideal biodegradable vascular stents Overall properties improvements Overall properties improvements Alloying of zinc Alloying of zinc
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| GB/T 7714 | Chen, Shiliang , Du, Tianming , Zhang, Hanbing et al. Methods for improving the properties of zinc for the application of biodegradable vascular stents [J]. | BIOMATERIALS ADVANCES , 2023 , 156 . |
| MLA | Chen, Shiliang et al. "Methods for improving the properties of zinc for the application of biodegradable vascular stents" . | BIOMATERIALS ADVANCES 156 (2023) . |
| APA | Chen, Shiliang , Du, Tianming , Zhang, Hanbing , Qi, Jing , Zhang, Yanping , Mu, Yongliang et al. Methods for improving the properties of zinc for the application of biodegradable vascular stents . | BIOMATERIALS ADVANCES , 2023 , 156 . |
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Abstract ：
Background: Although aortic valve reconstruction has become an alternative treatment for aortic valve disease, the design of the geometric parameters of the reconstructed leaflet still mainly depends on the experience of doctors. The present study investigates the effects of the height of the leaflets on the performance and biomechanical states of the reconstructed aortic valve. Methods: This numerical study was carried out using the finite element approach and the lattice Boltzmann method. The dynamic and biomechanical characteristics of the leaflets were evaluated by using the finite element approach, while the blood flow in the aortic sinus was evaluated by applying the lattice Boltzmann method. Three types of leaflets with different heights were designed. Then the dynamic characteristics, stress distribution, and effective orifice area (EOA) of the aortic valve and flow pattern were calculated as the indicators. Results: The results demonstrated that the height of the leaflets could indeed regulate the performance and the biomechanical states of the aortic valve. The rapid valve opening times of the 3 types of leaflets gradually reduced along with the decrease of the height ratio (HR_0.8: 120 ms vs. HR_1.0: 68 ms vs. HR_1.2: 31 ms), while the rapid valve closing times (RVCTs) of the 3 types of leaflets were similar to each other (approximately 75 ms). Moreover, the radial displacement of the leaflet at the fully open time increased along with the decrease of the HR of the leaflets (HR_0.8: 8 mm vs. HR_1.0: 6 mm vs. HR_1.2: 4 mm). In addition, the stress level of the leaflets also increased with the increase of the height of the leaflets (max stress, HR_0.8: 0.5 MPa, vs. HR_1.0: 1.1 MPa, vs. HR_1.2: 1.8 MPa). Similarly, the low velocity region near the ascending aortic wall and the wall shear stress (WSS) level on the ventricular side of the leaflets also increased along with the increase of the HR of the leaflets. Conclusions: In short, the height of the leaflets mainly affects the opening performance of the reconstructed aortic leaflets. The HR of the reconstructed leaflets for adults should be less than 1.0 to balance the opening and closing performance of aortic leaflets.
Keyword ：
Aortic valve reconstruction Aortic valve reconstruction fluid-structure interaction fluid-structure interaction biomechanics biomechanics lattice Boltzmann method lattice Boltzmann method hemodynamics hemodynamics
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| GB/T 7714 | Ma, Xinrui , Gao, Bin , Tao, Liang et al. Hemodynamic study of the effect of the geometric height of leaflets on the performance of the aortic valve under aortic valve reconstruction [J]. | JOURNAL OF THORACIC DISEASE , 2022 , 14 (5) : 1515-1525 . |
| MLA | Ma, Xinrui et al. "Hemodynamic study of the effect of the geometric height of leaflets on the performance of the aortic valve under aortic valve reconstruction" . | JOURNAL OF THORACIC DISEASE 14 . 5 (2022) : 1515-1525 . |
| APA | Ma, Xinrui , Gao, Bin , Tao, Liang , Ding, Jinli , Li, Shu , Qiao, Aike et al. Hemodynamic study of the effect of the geometric height of leaflets on the performance of the aortic valve under aortic valve reconstruction . | JOURNAL OF THORACIC DISEASE , 2022 , 14 (5) , 1515-1525 . |
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Abstract ：
Most of the studies on the finite element analysis (FEA) of biodegradable vascular stents (BVSs) during the degradation process have limited the accuracy of the simulation results due to the application of the uniform degradation model. This paper aims to establish an FEA model for the non-uniform degradation of BVSs by considering factors such as the dynamic changes of the corrosion properties and material properties of the element, as well as the pitting corrosion and stress corrosion. The results revealed that adjusting the corrosion rate according to the number of exposed surfaces of the element and reducing the stress threshold according to the corrosion status accelerates the degradation time of BVSs by 26% and 25%, respectively, compared with the uniform degradation model. The addition of the pitting model reduces the service life of the BVSs by up to 12%. The effective support of the stent to the vessel could reach at least 60% of the treatment effect before the vessel collapsed. These data indicate that the proposed non-uniform degradation model of BVSs with multiple factors produces different phenomena compared with the commonly used models and make the numerical simulation results more consistent with the real degradation scenario.
Keyword ：
biodegradable vascular stents biodegradable vascular stents non-uniform degradation non-uniform degradation continuum damage mechanics continuum damage mechanics finite element method finite element method
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| GB/T 7714 | Zhang, Hanbing , Du, Tianming , Chen, Shiliang et al. Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents [J]. | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
| MLA | Zhang, Hanbing et al. "Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents" . | JOURNAL OF FUNCTIONAL BIOMATERIALS 13 . 3 (2022) . |
| APA | Zhang, Hanbing , Du, Tianming , Chen, Shiliang , Liu, Yang , Yang, Yujia , Hou, Qianwen et al. Finite Element Analysis of the Non-Uniform Degradation of Biodegradable Vascular Stents . | JOURNAL OF FUNCTIONAL BIOMATERIALS , 2022 , 13 (3) . |
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Abstract ：
BACKGROUND: Inadequate scaffolding performance hinders the clinical application of the biodegradable zinc alloy stents. OBJECTIVE: In this study we propose a novel stent with the tenon-and-mortise structure to improve its scaffolding performance. METHODS: 3D models of stents were established in Pro/E. Based on the biodegradable zinc alloy material and two numerical simulation experiments were performed in ABAQUS. Firstly, the novel stent could be compressed to a small-closed ring by a crimp shell and can form a tenon-and-mortise structure after expanded by a balloon. Finally, 0.35 MPa was applied to the crimp shell to test the scaffolding performance of the novel stent and meanwhile compare it with an ordinary stent. RESULTS: Results showed that the novel stent decreased the recoiling ratio by 70.7% compared with the ordinary stent, indicating the novel structure improved the scaffolding performance of the biodegradable zinc alloy stent. CONCLUSION: This study proposes a novel design that is expected to improve the scaffolding performance of biodegradable stents.
Keyword ：
scaffolding stiffness scaffolding stiffness finite element analysis finite element analysis biodegradable stent biodegradable stent Zinc alloy Zinc alloy
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| GB/T 7714 | Wang, Sirui , Wu, Dandan , Li, Gaoyang et al. Finite element analysis of the mechanical performance of a zinc alloy stent with the tenon-and-mortise structure [J]. | TECHNOLOGY AND HEALTH CARE , 2022 , 30 (2) : 351-359 . |
| MLA | Wang, Sirui et al. "Finite element analysis of the mechanical performance of a zinc alloy stent with the tenon-and-mortise structure" . | TECHNOLOGY AND HEALTH CARE 30 . 2 (2022) : 351-359 . |
| APA | Wang, Sirui , Wu, Dandan , Li, Gaoyang , Peng, Kun , Mu, Yongliang , Ohta, Makoto et al. Finite element analysis of the mechanical performance of a zinc alloy stent with the tenon-and-mortise structure . | TECHNOLOGY AND HEALTH CARE , 2022 , 30 (2) , 351-359 . |
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Abstract ：
Percutaneous coronary intervention with stent implantation is one of the most commonly used approaches to treat coronary artery stenosis. Stent malapposition (SM) can increase the incidence of stent thrombosis, but the quantitative association between SM distance and stent thrombosis is poorly clarified. The objective of this study is to determine the biomechanical reaction mechanisms underlying stent thrombosis induced by SM and to quantify the effect of different SM severity grades on thrombosis. The thrombus simulation was performed in a continuous model based on the diffusion-convection response of blood substance transport. Simulated models included well-apposed stents and malapposed stents with various severities where the detachment distances ranged from 0 to 400 mu m. The abnormal shear stress induced by SM was considered a critical contributor affecting stent thrombosis, which was dependent on changing SM distances in the simulation. The results illustrate that the proportion of thrombus volume was 1.88% at a SM distance of 75 mu m (mild), 3.46% at 150 mu m, and 3.93% at 400 mu m (severe), but that a slight drop (3.18%) appeared at the detachment distance of 225 mu m (intermediate). The results indicate that when the SM distance was less than 150 mu m, the thrombus rose notably as the gap distance increased, whereas the progression of thrombogenicity weakened when it exceeded 150 mu m. Therefore, more attention should be paid when SM is present at a gap distance of 150 mu m. Moreover, when the SM length of stents are the same, thrombus tends to accumulate downstream towards the distal end of the stent as the SM distance increases.
Keyword ：
stent malapposition stent malapposition dynamic thrombus formation dynamic thrombus formation shear-induced thrombus aggregation shear-induced thrombus aggregation computational fluid dynamics computational fluid dynamics 3D continuum model 3D continuum model stent thrombosis stent thrombosis
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| GB/T 7714 | Qu, Zhuoran , Wei, Hongge , Du, Tianming et al. Computational simulation of stent thrombosis induced by various degrees of stent malapposition [J]. | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2022 , 10 . |
| MLA | Qu, Zhuoran et al. "Computational simulation of stent thrombosis induced by various degrees of stent malapposition" . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10 (2022) . |
| APA | Qu, Zhuoran , Wei, Hongge , Du, Tianming , Qiao, Aike . Computational simulation of stent thrombosis induced by various degrees of stent malapposition . | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY , 2022 , 10 . |
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Abstract ：
ObjectiveHemodynamics-induced low wall shear stress (WSS) is one of the critical reasons leading to vascular remodeling. However, the coupling effects of WSS and cellular kinetics have not been clearly modeled. The aim of this study was to establish a multiscale modeling approach to reveal the vascular remodeling behavior under the interaction between the macroscale of WSS loading and the microscale of cell evolution. MethodsComputational fluid dynamics (CFD) method and agent-based model (ABM), which have significantly different characteristics in temporal and spatial scales, were adopted to establish the multiscale model. The CFD method is for the second/organ scale, and the ABM is for the month/cell scale. The CFD method was used to simulate blood flow in a vessel and obtain the WSS in a vessel cross-section. The simulations of the smooth muscle cell (SMC) proliferation/apoptosis and extracellular matrix (ECM) generation/degradation in a vessel cross-section were performed by using ABM. During the simulation of the vascular remodeling procedure, the damage index of the SMC and ECM was defined as deviation from the obtained WSS. The damage index decreased gradually to mimic the recovery of WSS-induced vessel damage. Results(1) The significant wall thickening region was consistent with the low WSS region. (2) There was no evident change of wall thickness in the normal WSS region. (3) When the damage index approached to 0, the amount and distribution of SMCs and ECM achieved a stable state, and the vessel reached vascular homeostasis. ConclusionThe established multiscale model can be used to simulate the vascular remodeling behavior over time under various WSS conditions.
Keyword ：
multiscale modeling multiscale modeling wall shear stress wall shear stress vascular remodeling vascular remodeling agent-based model agent-based model computational fluid dynamics computational fluid dynamics
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| GB/T 7714 | Chen, Shiliang , Zhang, Hanbing , Hou, Qianwen et al. Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress [J]. | FRONTIERS IN PHYSIOLOGY , 2022 , 12 . |
| MLA | Chen, Shiliang et al. "Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress" . | FRONTIERS IN PHYSIOLOGY 12 (2022) . |
| APA | Chen, Shiliang , Zhang, Hanbing , Hou, Qianwen , Zhang, Yu , Qiao, Aike . Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress . | FRONTIERS IN PHYSIOLOGY , 2022 , 12 . |
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