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学者姓名：盛望
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Abstract ：
Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance. Nevertheless, the problem of ferroptosis resistance in certain cancer cells has been identified. This review first, investigates the mechanisms of ferroptosis induction in cancer cells. Next, the problem of cancer cell resistance to ferroptosis, as well as the underlying mechanisms is discussed. Recently discovered ferroptosis-suppressing biomarkers have been described. The various types of nanoparticles that can induce ferroptosis are also discussed. Given the ability of nanoparticles to combine multiple agents, this review proposes nanoparticle-based ferroptosis cell death as a viable method of circumventing this resistance. This review suggests combining ferroptosis with other forms of cell death, such as apoptosis, cuproptosis and autophagy. It also suggests combining ferroptosis with immunotherapy.
Keyword ：
nanoparticles nanoparticles combinatory therapy combinatory therapy cancer therapy cancer therapy ferroptosis ferroptosis ferroptosis resistance ferroptosis resistance
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| GB/T 7714 | Adzavon, Kodzo Prosper , Zhao, Weijian , He, Xuesong et al. Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution [J]. | FRONTIERS IN PHARMACOLOGY , 2024 , 15 . |
| MLA | Adzavon, Kodzo Prosper et al. "Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution" . | FRONTIERS IN PHARMACOLOGY 15 (2024) . |
| APA | Adzavon, Kodzo Prosper , Zhao, Weijian , He, Xuesong , Sheng, Wang . Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution . | FRONTIERS IN PHARMACOLOGY , 2024 , 15 . |
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Abstract ：
BackgroundCombinatorial immunotherapy strategies for enhancing the responsiveness of immune system have shown great promise for cancer therapy. Engineered nanoformulation incorporated toll-like receptor (TLR) 9 agonist CpG ODN has shown more positive results in suppressing tumor growth and can significantly enhance other immunotherapy activity with combinatorial effects due to the innate and adaptive immunostimulatory effects of CpG.ResultsIn the present work, protamine sulfate (PS) and carboxymethyl beta-glucan (CMG) were used as nanomaterials to form nanoparticles through a self-assembly approach for CpG ODN encapsulation to generate CpG ODN-loaded nano-adjuvant (CNPs), which was subsequently mixed with the mixture of mouse melanoma-derived antigens of tumor cell lysates (TCL) and neoantigens to develop vaccine for anti-tumor immunotherapy. The obtained results showed that CNPs was able to effectively deliver CpG ODN into murine bone marrow-derived dendritic cells (DC) in vitro, and remarkably stimulate the maturation of DC cells with proinflammatory cytokine secretion. In addition, in vivo analysis showed that CNPs enhanced anti-tumor activity of PD1 antibody and CNPs-adjuvanted vaccine based on the mixture antigens of melanoma TCL and melanoma-specific neoantigen could not only induce anti-melanoma cellular immune responses, but also elicit melanoma specific humoral immune responses, which significantly inhibited xenograft tumor growth. Furthermore, CD16 CAR-T cells were generated by expressing CD16-CAR in CD3(+)CD8(+) murine T cells.ConclusionOur results eventually showed that anti-melanoma antibodies induced by CNPs-adjuvanted TCL vaccines were able to collaborate with CD16-CAR-T cells to generate an enhanced targeted anti-tumor effects through ADCC (antibody dependent cell cytotoxicity) approach. CD16 CAR-T cells has thus a great potential to be an universal promising strategy targeting on solid tumor synergistic immunotherapy via co-operation with TCL-based vaccine.
Keyword ：
CpG ODN CpG ODN Neoantigen Neoantigen CD16 CD16 Vaccine Vaccine Immunotherapy Immunotherapy
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| GB/T 7714 | Zhang, Xiaofei , Hu, Qin , He, Xuesong et al. CD16 CAR-T cells enhance antitumor activity of CpG ODN-loaded nanoparticle-adjuvanted tumor antigen-derived vaccinevia ADCC approach [J]. | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
| MLA | Zhang, Xiaofei et al. "CD16 CAR-T cells enhance antitumor activity of CpG ODN-loaded nanoparticle-adjuvanted tumor antigen-derived vaccinevia ADCC approach" . | JOURNAL OF NANOBIOTECHNOLOGY 21 . 1 (2023) . |
| APA | Zhang, Xiaofei , Hu, Qin , He, Xuesong , Cui, Xinyue , Liang, Zhaoyuan , Wang, Li et al. CD16 CAR-T cells enhance antitumor activity of CpG ODN-loaded nanoparticle-adjuvanted tumor antigen-derived vaccinevia ADCC approach . | JOURNAL OF NANOBIOTECHNOLOGY , 2023 , 21 (1) . |
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Abstract ：
皮肤恶性黑色素瘤是恶性黑色素瘤的一种常见类型，具有极强的转移性和侵袭性，同时具有高突变负荷、肿瘤间和肿瘤内遗传异质性以及复杂的肿瘤微环境。黑色素瘤潜在机制的深度研究对于理解肿瘤进展和对治疗的反应至关重要。本文总结了单细胞转录组测序技术在黑色素瘤研究中的应用，从构建皮肤黑色素瘤的基因表达图谱、表征肿瘤间和肿瘤内的异质性和探究肿瘤微环境等方面深度剖析其在皮肤恶性黑色素瘤中的研究进展。并且介绍了目前常用的单细胞转录组数据库及其特点。最后，本文介绍了可与单细胞转录组测序技术结合应用的空间转录组技术，作为当下的研究热点，空间转录组技术与单细胞测序技术结合应用可从时间和空间两个维度重塑肿瘤微环境，为深入了解肿瘤提供了可以继续扩展的框架。
Keyword ：
Single Cell Sequencing Single Cell Sequencing 肿瘤微环境 肿瘤微环境 Drug Resistance Drug Resistance 单细胞测序 单细胞测序 黑色素瘤 黑色素瘤 Heterogeneity Heterogeneity 异质性 异质性 耐药性 耐药性 Melanoma Melanoma Tumor Microenvironment Tumor Microenvironment
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| GB/T 7714 | 王晓丽 , 韩中杰 , 韩梦洋 et al. 单细胞转录组测序技术在皮肤恶性黑色素瘤中的研究进展 [J]. | 生物医学 , 2023 , 13 (2) : 199-210 . |
| MLA | 王晓丽 et al. "单细胞转录组测序技术在皮肤恶性黑色素瘤中的研究进展" . | 生物医学 13 . 2 (2023) : 199-210 . |
| APA | 王晓丽 , 韩中杰 , 韩梦洋 , 李雅琪 , 盛望 . 单细胞转录组测序技术在皮肤恶性黑色素瘤中的研究进展 . | 生物医学 , 2023 , 13 (2) , 199-210 . |
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Abstract ：
肝细胞癌(Hepatic Cellular Carcinoma, HCC)是全球发病率较高的癌症之一且其死亡率在全球每年持续增加约2%~3%。氧化应激(Oxidative Stress, OS)是指当生物体细胞在遭遇外界刺激时，机体细胞内部产生大量超氧化物，如单线态氧(1O2)、过氧化氢(H2O2)，超氧阴离子(O2-)等，这些物质致机体细胞内氧化与抗氧化作用失衡，最终导致细胞和组织的损伤。氧化应激被认为是恶性肿瘤的起因之一。铁死亡(Ferroptosis)是近年发现的一种铁依赖性的新型细胞程序性死亡方式。本文主要阐述了肝细胞癌中氧化应激对铁死亡的影响的相关研究进展。
Keyword ：
Ferroptosis Ferroptosis Hepatic Cellular Carcinoma Hepatic Cellular Carcinoma Active Oxygen Active Oxygen 肝细胞癌 肝细胞癌 氧化应激 氧化应激 活性氧 活性氧 铁死亡 铁死亡 Oxidative Stress Oxidative Stress
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| GB/T 7714 | 李雅琪 , 徐弘庭 , 赵维坚 et al. 肝细胞癌中的铁死亡与氧化应激 [J]. | 生物医学 , 2023 , 13 (3) : 293-302 . |
| MLA | 李雅琪 et al. "肝细胞癌中的铁死亡与氧化应激" . | 生物医学 13 . 3 (2023) : 293-302 . |
| APA | 李雅琪 , 徐弘庭 , 赵维坚 , 肖向茜 , 韩梦洋 , 王晓丽 et al. 肝细胞癌中的铁死亡与氧化应激 . | 生物医学 , 2023 , 13 (3) , 293-302 . |
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| GB/T 7714 | Wang, Li , Li, Jintao , Zhang, Na et al. Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020) [J]. | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2021 , 558 : 239-239 . |
| MLA | Wang, Li et al. "Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020)" . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 558 (2021) : 239-239 . |
| APA | Wang, Li , Li, Jintao , Zhang, Na , Zhang, Xiaofei , Xia, Yang , Chai, Binbin et al. Investigations of EGFR configurations on tumor cell surface by high-resolution electron microscopy (vol 532, pg 179, 2020) . | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , 2021 , 558 , 239-239 . |
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Abstract ：
Cancer vaccines targeting tumor specific neoantigens derived from nonsynonymous mutations of tumor cells have emerged as an effective approach to induce antitumor T cells responses for personalized cancer immunotherapy. Despite the enormous potential of synthetic peptides as a common modality for neoantigen vaccines, their practical efficacy was limited due to their relatively low immunogenicity. Herein, we modify neoantigen peptide (Adpgk) derived from MC-38 colon carcinoma by supplementing ten consecutive positively-charged lysines (10 K-Adpgk) to obtain cationic polypeptide. And then we made them self-assemble with toll-like receptor 9 (TLR-9) agonist CpG oligodeoxynucleotides (CpG ODN) adjuvant directly forming antigen/adjuvant integrated nanocomplexes (PCNPs) through electrostatic interaction for potent tumor immunotherapy. The optimal formed PCNPs were around 175 nm with uniform size distribution and could maintain stability in physiological saline solution. CpG ODN and 10 K-Adpgk in the formed PCNPs could be effectively uptake by dendritic cells (DCs) and stimulate the maturation of DCs as well as improving the efficiency of antigen crosspresentation efficiency in vitro. Furthermore, the PCNPs vaccine could markedly improve neoantigen and adjuvant co-delivery efficiency to lymphoid organs and activate cytotoxic T cells. In addition, vaccination with PCNPs could not only offer prophylactic to protect mice from challenged MC-38 colorectal tumors, but also achieve a better anti-tumor effect in an established colorectal tumor model, and significantly prolong the survival rate of tumor-bearing mice. Therefore, this work provided a versatile but effective method for neoantigen peptide and CpG ODN co-assembly vaccine platform for efficient colorectal cancer immunotherapy.
Keyword ：
CpG ODN CpG ODN Neoantigen Neoantigen Immunotherapy Immunotherapy Peptide Peptide Nanovaccine Nanovaccine
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| GB/T 7714 | Liang, Zhaoyuan , Cui, Xinyue , Yang, Liqun et al. Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy [J]. | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2021 , 608 . |
| MLA | Liang, Zhaoyuan et al. "Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy" . | INTERNATIONAL JOURNAL OF PHARMACEUTICS 608 (2021) . |
| APA | Liang, Zhaoyuan , Cui, Xinyue , Yang, Liqun , Hu, Qin , Li, Danyang , Zhang, Xiaofei et al. Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy . | INTERNATIONAL JOURNAL OF PHARMACEUTICS , 2021 , 608 . |
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Abstract ：
Owing to its aggressive biological behavior, the lack of specific targets, and the strong therapeutic resistance of triple negative breast cancer (TNBC), current therapeutic strategies are still limited. The combination of multiple treatments has been confirmed as a promising strategy for TNBC therapy. However, the efficacy of combination therapy can be restricted due to increasing therapeutic resistance to various treatments. Herein, we constructed a nanodiamond (ND)-based nanoplatform for augmented mild-temperature photothermal/chemo combination therapy against TNBC, weakening the therapeutic resistance via autophagy inhibition enabled by the NDs. A layer-by-layer self-assembly approach was utilized to construct the ND-based nanoplatform. First, the NDs were modified with protamine sulphate (PS). Meanwhile, the photosensitizer indocyanine green (ICG) and the HSP70 small molecule inhibitor apoptozole (APZ) could be synchronously incorporated to form positively charged PS@ND (ICG + APZ). Then negatively charged hyaluronic acid (HA) was assembled onto the outer face of PS@ND (ICG + APZ) to form the NPIAs. Finally, the positively charged small molecule anti-cancer drug doxorubicin (DOX) could be adsorbed onto the surface of the NPIAs through electrostatic interactions (NPIADs). The resulting NPIADs could be triggered by NIR laser irradiation to exhibit enhanced mild-temperature photothermal therapy (PTT) effects via suppressing the expression of HSP70, and PTT combined with chemotherapy could further enhance the anti-tumor efficacy. Subsequently, the sensitivity of MDA-MB-231 cells could be significantly improved through the weakening of the thermal/drug resistance via autophagy inhibition, leading to augmented combination therapy that is efficient both in vitro and in vivo. Furthermore, the NPIADs could be used as a theranostic nanoplatform for fluorescence (FL) and photoacoustic (PA) imaging. Taken together, this study demonstrated a multifunctional ND-based nanoplatform for FL/PA imaging-guided augmented mild-temperature photothermal/chemo combination therapy via an autophagy regulation strategy against TNBC.
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| GB/T 7714 | Cui, Xinyue , Liang, Zhaoyuan , Lu, Jianqing et al. A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy [J]. | NANOSCALE , 2021 , 13 (31) : 13375-13389 . |
| MLA | Cui, Xinyue et al. "A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy" . | NANOSCALE 13 . 31 (2021) : 13375-13389 . |
| APA | Cui, Xinyue , Liang, Zhaoyuan , Lu, Jianqing , Wang, Xuan , Jia, Fan , Hu, Qin et al. A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy . | NANOSCALE , 2021 , 13 (31) , 13375-13389 . |
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Abstract ：
Uniting combinational strategies has been confirmed to be a robust choice for high-performance cancer treatment due to their abilities to overcome tumor heterogeneity and complexity. However, the development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. In this study, we integrated multicomponent hyaluronic acid (HA), protamine (PS), nanodiamonds (NDs), curcumin (Cur), and IR780 into a single nanoplatform (denoted as HPNDIC) based on the combination of hydrophobic and electrostatic noncovalent interactions for dual-modal fluorescence/photoacoustic imaging guided ternary collaborative Cur/photothermal/photodynamic combination therapy of triple-negative breast cancer (TNBC). A two-step coordination assembly strategy was utilized to realize this purpose. In the first step, PS was utilized to modify the NDs clusters to form positively charged PS@NDs (PND) and the simultaneous encapsulation of the natural small-molecule drug Cur and the photosensitive small-molecule IR780 (PNDIC). Second, HA was adsorbed onto the outer surface of the PNDIC through charge complexation for endowing a tumor-targeting ability (HPNDIC). The resulting HPNDIC had a uniform size, high drug-loading ability, and excellent colloidal stability. It was found that under the near-infrared irradiation condition, IR780 could be triggered to exhibit both PTT/PDT dual-pattern therapy effects, leading to an enhanced therapy efficiency of Cur both in vitro and in vivo with good biocompatibility. Due to the intrinsic imaging property of IR780, the biodistribution and accumulation behavior of HPNDIC in vivo could be monitored by dual-modal fluorescence/photoacoustic imaging. Taken together, our current work demonstrated the assembly of a NDs-based multicomponent theranostic platform for dual-modal fluorescence/photoacoustic imaging guided triple-collaborative Cur/photothermal/photodynamic against TNBC.
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| GB/T 7714 | Cui Xinyue , Deng Xiongwei , Liang Zhaoyuan et al. Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy. [J]. | Biomaterials science , 2021 , 9 (10) : 3838-3850 . |
| MLA | Cui Xinyue et al. "Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy." . | Biomaterials science 9 . 10 (2021) : 3838-3850 . |
| APA | Cui Xinyue , Deng Xiongwei , Liang Zhaoyuan , Lu Jianqing , Shao Leihou , Wang Xuan et al. Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy. . | Biomaterials science , 2021 , 9 (10) , 3838-3850 . |
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In the present study, we evaluated adjuvant potential of Poria cocos polysaccharide (PCP) on the Th1-type immune responses of C57/BL6 mice against ovalbumin (OVA). We first determined the effect of PCP on maturation of murine bone marrow derived dendritic cells (BMDCs), PCP significantly upregulated surface expression of MHCII, CD40, CD80, CD86 and enhanced production of IL-6 and IL-12p40. In addition, PCP affected receptor-mediated endocytosis, but not pinocytosis in BMDCs. Furthermore, OVA + PCP immunization induced specific cytotoxic CD8+ T cell killing of OVA (257-264) peptide pulsed cell. When mice were immunized subcutaneously in a week interval with OVA + PCP. Serum were collected for measuring OVA-specific antibody and splenocytes were harvested for analyzing CD69, IFN-γ ELISpot and cytokines production. The result indicated that OVA-specific IgG, IgG2a and IgG1 antibody levels in serum were significantly elevated by PCP compared with control. PCP increased OVA-specific IFN-γ-secreting CD8+, CD4+ T cells, promoted CD8+ T cell proliferation and up-regulated Th-1 type (IFN-γ, IL-2) cytokine production. In conclusion, data suggest that PCP enhanced cellular immune response and possess potential as a vaccine adjuvant for Th1 immune response.
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| GB/T 7714 | Dong Xiaoxiao , Li Boye , Yu Boyang et al. Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice. [J]. | PloS one , 2021 , 16 (1) : e0245207 . |
| MLA | Dong Xiaoxiao et al. "Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice." . | PloS one 16 . 1 (2021) : e0245207 . |
| APA | Dong Xiaoxiao , Li Boye , Yu Boyang , Chen Tian , Hu Qin , Peng Bo et al. Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice. . | PloS one , 2021 , 16 (1) , e0245207 . |
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Abstract ：
Traditional brazing quality inspection methods find it difficult to detect brazing layer defects on heteromorphic workpieces. Thus, a non-destructive testing technology based on a thermal probe is developed in this work. Scanning thermal resistance testing and analysis are carried out for two types of workpiece samples with different structures, and an evaluation calculation method is proposed to effectively characterize the brazing effect of the workpiece. By comparison with standard workpieces, qualified brazing layer products can be selected. In addition, the feasibility of this method is verified by ANSYS thermal simulations. In comparison with the x ray, it also has shown the superiority of this method. Experimental results show that this method can effectively evaluate the brazing layer quality of workpieces with heteromorphic and complex structures, and the reliability of the workpiece is further improved. Published under an exclusive license by AIP Publishing.
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| GB/T 7714 | Hu, Chaoxu , Feng, Shiwei , Zhang, Yamin et al. A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe [J]. | REVIEW OF SCIENTIFIC INSTRUMENTS , 2021 , 92 (8) . |
| MLA | Hu, Chaoxu et al. "A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe" . | REVIEW OF SCIENTIFIC INSTRUMENTS 92 . 8 (2021) . |
| APA | Hu, Chaoxu , Feng, Shiwei , Zhang, Yamin , He, Xin , Bai, Kun , Wang, Sheng et al. A new method for detecting heteromorphic workpiece brazing layer quality based on thermal probe . | REVIEW OF SCIENTIFIC INSTRUMENTS , 2021 , 92 (8) . |
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