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学者姓名：陈涛
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Abstract ：
本发明涉及脉搏波血压测量技术领域，揭露了一种基于激光自混合干涉的血压检测方法，利用激光自混合探测系统采集待检测对象的脉搏波自混合信号；对所述脉搏波自混合信号进行信号降噪以及脉搏波曲线重构，获取脉搏波信号的特征向量和特征参数；将所述获取的脉搏波信号的特征向量输入基于深层前馈神经网络的人体血压数值的预测模型；利用所述基于深层前馈神经网络的人体血压数值的预测模型输出待检测对象的血压值。本发明的激光自混合干涉技术，可以实现同时探测脉搏波多个特征参数；具有成本低廉、精度高、结构简单、适用场景丰富等优点，十分适合集成在血压监测系统内。
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| GB/T 7714 | 赵宇 , 姚喜杰 , 陈涛 . 基于激光自混合干涉的血压检测方法及系统 : CN202310217566.9[P]. | 2023-03-03 . |
| MLA | 赵宇 等. "基于激光自混合干涉的血压检测方法及系统" : CN202310217566.9. | 2023-03-03 . |
| APA | 赵宇 , 姚喜杰 , 陈涛 . 基于激光自混合干涉的血压检测方法及系统 : CN202310217566.9. | 2023-03-03 . |
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Abstract ：
The regeneration of the injured nerve and recovery of its function have brought attention in the medical field. Electrical stimulation (ES) can enhance the cellular biological behavior and has been widely studied in the treatment of neurological diseases. Microfluidic technology can provide a cell culture platform with the well-controlled environment. Here a novel microfluidic/microelectrode composite microdevice was developed by embedding the microelectrodes to the microfluidic platform, in which microfluidics provided a controlled cell culture platform, and ES promoted the NSCs proliferation. We performed ES on rat neural stem cells (NSCs) to observe the effect on their growth, differentiation, proliferation, and preliminary explored the ES influence on cells in vitro. The results of immunofluorescence showed that ES had no significant effect on the NSCs specific expression, and the NSCs specific expression reached 98.9% +/- 0.4% after three days of ES. In addition, ES significantly promoted cell growth and the cell proliferation rate reached 49.41%. To conclude, the microfluidic/microelectrode composite microdevice can play a positive role in the nerve injury repair and fundamental research of neurological diseases. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Electrical stimulation Electrical stimulation Microfluidics Microfluidics Microelectrode Microelectrode NSCs NSCs Proliferation Proliferation
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| GB/T 7714 | Li, Qian , Kang, Bodong , Wang, Libin et al. Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation [J]. | CHINESE CHEMICAL LETTERS , 2022 , 33 (3) : 1308-1312 . |
| MLA | Li, Qian et al. "Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation" . | CHINESE CHEMICAL LETTERS 33 . 3 (2022) : 1308-1312 . |
| APA | Li, Qian , Kang, Bodong , Wang, Libin , Chen, Tao , Zhao, Yu , Feng, Shilun et al. Microfluidics embedded with microelectrodes for electrostimulation of neural stem cells proliferation . | CHINESE CHEMICAL LETTERS , 2022 , 33 (3) , 1308-1312 . |
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Abstract ：
This paper presents an integrated circuit design for neural recording chip with integrated CMOS electrode array. The implementation of on-chip electrode array can greatly improve the implantability of neural recording systems. The chip is mainly composed of a neural recording analog front end and an 8x8 microelectrode array designed in CMOS process technology. The analog front end of the neural recording circuit adopts chopper technique, which effectively reduces the lowfrequency noise. The whole circuit has been designed in Cadence using the SMIC 180-nm CMOS process. The simulation results show that the signal with a frequency ranging from 0-2kHz and the amplitude ranging from 0-500 mu V can be independently recorded through the electrodes with a control terminal. The electrode array and the recording analog front end IC are partly overlapped using different metal layers, saving the chip area. The chip area of the final circuit with 64 electrodes is only 1400 mu m x 760 mu m.
Keyword ：
neural recording neural recording microelectrode array microelectrode array CMOS CMOS chopper chopper
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| GB/T 7714 | Zhang, Ronghao , Liu, Xu , Chen, Zhijie et al. A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface [J]. | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS , 2022 : 139-143 . |
| MLA | Zhang, Ronghao et al. "A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface" . | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS (2022) : 139-143 . |
| APA | Zhang, Ronghao , Liu, Xu , Chen, Zhijie , Wan, Peiyuan , Chen, Tao . A Neural Recording IC Design with on-chip CMOS Electrode Array for Brain-machine Interface . | 2022 IEEE ASIA PACIFIC CONFERENCE ON CIRCUITS AND SYSTEMS, APCCAS , 2022 , 139-143 . |
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Abstract ：
本发明涉及一种基于自混合干涉的双路微位移探测装置、方法及系统，属于微位移探测领域，装置包括：激光器、第一光电探测器、分光棱镜、第二光电探测器以及透镜；激光器发出激光，分解成两路光线，一路光线入射到第一光电探测器，监测激光器输出功率受到激光自混合干涉影响而产生的实时变化，另一路由透镜聚焦至待测物体表面；PZT驱动的待测物体作周期的往返运动并反射生成反射信号光，逆向分解为另外两路光线，其中一路反射信号光原路返回至激光器，引起激光输出功率实时变化，被第一光电探测器进行测量记录；另一路反射信号光被反射进入第二光电探测器中，由第二光电探测器进行探测记录。本发明中的上述方案能够实现微位移的精确探测。
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| GB/T 7714 | 赵宇 , 张梦雷 , 陈涛 . 一种基于自混合干涉的双路微位移探测装置、方法及系统 : CN202211306618.1[P]. | 2022-10-25 . |
| MLA | 赵宇 et al. "一种基于自混合干涉的双路微位移探测装置、方法及系统" : CN202211306618.1. | 2022-10-25 . |
| APA | 赵宇 , 张梦雷 , 陈涛 . 一种基于自混合干涉的双路微位移探测装置、方法及系统 : CN202211306618.1. | 2022-10-25 . |
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Abstract ：
本发明提供了一种复合神经微器件及其制造方法，其中的复合神经微器件包括电极单元、细胞培养单元和封装单元，所述电极单元包括刺激电极及电极导线，所述电极导线将外部电流传到刺激电极；所述细胞培养单元位于电极正上方，用于承载神经干细胞；所述封装单元包含狭缝薄膜以及绝缘膜，所述狭缝薄膜位于细胞培养单元上方，防止细胞培养液漏出，所述绝缘膜包覆在电极导线以及刺激电极除正面外的其他部分。上述复合神经微器件及其制造方法使得电刺激与神经干细胞能够联合作用。
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| GB/T 7714 | 陈涛 , 李荣京 , 赵宇 et al. 复合神经微器件及其制造方法 : CN202211278727.7[P]. | 2022-10-19 . |
| MLA | 陈涛 et al. "复合神经微器件及其制造方法" : CN202211278727.7. | 2022-10-19 . |
| APA | 陈涛 , 李荣京 , 赵宇 , 刘旭 , 王力斌 . 复合神经微器件及其制造方法 : CN202211278727.7. | 2022-10-19 . |
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Abstract ：
This paper presents chip implementation of the integrated neural recording and stimulation system with stimulation-induced artifact suppression. The implemented chip consists of low-power neural recording circuits, stimulation circuits, and action potential detection circuits. These circuits constitute a closed-loop simultaneous neural recording and stimulation system for biomedical devices, and a proposed artifact suppression technique is used in the system. Moreover, this paper also presents the measurement and experiment results of the implemented 4-to-4 channel neural recording and stimulation chip with 0.18 mu m CMOS technology. The function and efficacy of simultaneous neural recording and stimulation is validated in both in vivo and animal experiments.
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| GB/T 7714 | Liu, Xu , Li, Juzhe , Chen, Tao et al. A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices [J]. | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
| MLA | Liu, Xu et al. "A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices" . | JOURNAL OF HEALTHCARE ENGINEERING 2021 (2021) . |
| APA | Liu, Xu , Li, Juzhe , Chen, Tao , Wang, Wensi , Je, Minkyu . A Neural Recording and Stimulation Chip with Artifact Suppression for Biomedical Devices . | JOURNAL OF HEALTHCARE ENGINEERING , 2021 , 2021 . |
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Abstract ：
To provide a larger area and larger regional selectivity of light stimulation in the application of optogenetics, a multi-channel optogenetic stimulation system with a simple structure, wireless control of stimulation parameters and independent control was developed by our research group. A mu LED chip was used as the light source, and lithography and micro-welding technology were used to fabricate a blue light stimulator with an array light source. The wireless control function of the stimulator was realised using the wireless communication module. The size and weight of the photic stimulator were 46 mm x 30 mm and 7. 134 g, respectively. The results showed that the maximum output optical power of the optrode's surface was 24. 6 mW, which met the requirements of activating neurones by ChR2. The adjustable range of the output optical frequency was 1-500 Hz, while the maximum output error was less than 1%. The adjustable range of the duty cycle was 0-100%, while the maximum distance of the wireless communication was 50 m. This system can be used in the fields of optogenetic regulation, cell culture and fields that require a large area of light. Finally, it provides an effective tool for the regulation and research of neural circuits.
Keyword ：
medical optics medical optics mu LED array mu LED array light stimulation light stimulation optogenetic optogenetic wireless control wireless control
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| GB/T 7714 | Su Liangchuang , Chen Tao . Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro [J]. | LASER & OPTOELECTRONICS PROGRESS , 2021 , 58 (19) . |
| MLA | Su Liangchuang et al. "Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro" . | LASER & OPTOELECTRONICS PROGRESS 58 . 19 (2021) . |
| APA | Su Liangchuang , Chen Tao . Wireless Stimulation System with Multiple Channels and Independent Regulation for Optogenetics in Vitro . | LASER & OPTOELECTRONICS PROGRESS , 2021 , 58 (19) . |
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Abstract ：
本发明提供一种多通道无线光遗传刺激系统及方法，包括上位机、光刺激器以及阵列式刺激光极，所述光刺激器包括多个刺激通道，不同刺激通道与阵列式刺激光极的不同区域电连通，所述上位机用于设置光刺激参数，所述光刺激参数包括脉冲的频率、占空比、刺激时间和一个或多个刺激通道，所述上位机和光刺激器无线连接，所述光刺激器接收上位机设置的光刺激参数，输出电脉冲信号给光刺激参数中刺激通道电连通的阵列式刺激光极的区域。上述方法及系统能独立选择刺激的区域。
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| GB/T 7714 | 陈涛 , 苏良闯 , 赵宇 et al. 多通道无线光遗传刺激系统及方法 : CN202110081735.1[P]. | 2021-01-21 . |
| MLA | 陈涛 et al. "多通道无线光遗传刺激系统及方法" : CN202110081735.1. | 2021-01-21 . |
| APA | 陈涛 , 苏良闯 , 赵宇 , 康博栋 . 多通道无线光遗传刺激系统及方法 : CN202110081735.1. | 2021-01-21 . |
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Abstract ：
本发明提供一种脑微器件及其制造方法，包括电刺激部分和细胞培养部分，所述电刺激部分包括刺激电路和刺激电极，所述刺激电极为可植入刺激电极，一部分刺激电极作为正极，另一部分刺激电极作为负极，所述刺激电路产生电流传到刺激电极，通过外界液体环境导电，将电流从正极流向负极；所述细胞培养部分包括外轮廓以及设置在所述外轮廓上表面的至少三个腔室，第一腔室用于培养干细胞，第二腔室作为出液口，第三腔室作为进液口，腔室之间通过微流控通道相连。上述脑微器件及其制造方法使得干细胞和电刺激共同作用。
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| GB/T 7714 | 陈涛 , 李倩 , 康博栋 et al. 一种脑微器件及其制造方法 : CN202110088660.X[P]. | 2021-01-22 . |
| MLA | 陈涛 et al. "一种脑微器件及其制造方法" : CN202110088660.X. | 2021-01-22 . |
| APA | 陈涛 , 李倩 , 康博栋 , 杨艺 , 马娟棠 . 一种脑微器件及其制造方法 : CN202110088660.X. | 2021-01-22 . |
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Abstract ：
A novel carbon nanotubes/porous-network carbon micron tubes/silk fibroin (CPS) composite film neural electrode was presented and characterized. This electrode was fabricated through assembling dispersed carbon nanotubes (CNTs) by phytic acid onto the porous silk fibroin film. Afterward, the silk fibroin around the CNTs was carbonized by laser irradiation, producing porous-network carbon microtubes with good conductivity and biological compatibility. The structure of the CPS composite film was characterized by scanning electron microscopy and Raman spectroscopy. Cyclic voltammetry, electrochemical impedance spectroscopy, and safe charge injection limit (Q(inj)) of the CPS electrode were also measured by the three-electrode system, and the results exhibited outstanding electrochemical properties with the achieved Q(inj) of 5.7 mC/cm(2). This work provides a promising approach for the preparation of a long-term implanted neural electrode with high charge injection ability and good biocompatibility.
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| GB/T 7714 | Shen, Xuefei , Zhao, Yu , Li, Qian et al. Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode [J]. | AIP ADVANCES , 2020 , 10 (4) . |
| MLA | Shen, Xuefei et al. "Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode" . | AIP ADVANCES 10 . 4 (2020) . |
| APA | Shen, Xuefei , Zhao, Yu , Li, Qian , Chen, Tao . Construction and electrochemical properties determination of carbon nanotubes/porous-network carbon micron tubes/silk fibroin composite film neural electrode . | AIP ADVANCES , 2020 , 10 (4) . |
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