Vascular　endothelial　growth　factor-2　receptor　(VEGFR-2)　kinase　is　a　promising　target　for　the　development　of　novel　anticancer　drugs.　Molecular　docking　modeling　was　performed　on　a　series　of　4-aryl-1,4-dihydropyridines　derivatives　to　evaluate　the　structural　basis　for　VEGFR-2　inhibitory　activity.　Some　4-aryl-1,4-dihydropyridines　were　synthesized　in　the　reaction　of　aromatic　aldehydes　and　ethyl　propiolate　with　anilines　in　acetic　acid.　The　biological　activities　were　evaluated　against　the　cells　A549,　A431　and　Hep-G2.　The　results　indicated　that　4-aryl-1,4-dihydropyridines　could　be　the　promising　potential　VEGFR-2　inhibitors.