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Author:

Wu, Mixia (Wu, Mixia.) | Zhang, Dianchen (Zhang, Dianchen.) | Liu, Aiyi (Liu, Aiyi.)

Indexed by:

Scopus SCIE PubMed

Abstract:

New biomarkers continue to be developed for the purpose of diagnosis, and their diagnostic performances are typically compared with an existing reference biomarker used for the same purpose. Considerable amounts of research have focused on receiver operating characteristic curves analysis when the reference biomarker is dichotomous. In the situation where the reference biomarker is measured on a continuous scale and dichotomization is not practically appealing, an index was proposed in the literature to measure the accuracy of a continuous biomarker, which is essentially a linear function of the popular Kendall's tau. We consider the issue of estimating such an accuracy index when the continuous reference biomarker is measured with errors. We first investigate the impact of measurement errors on the accuracy index, and then propose methods to correct for the bias due to measurement errors. Simulation results show the effectiveness of the proposed estimator in reducing biases. The methods are exemplified with hemoglobin A1c measurements obtained from both the central lab and a local lab to evaluate the accuracy of the mean data obtained from the metered blood glucose monitoring against the centrally measured hemoglobin A1c from a behavioral intervention study for families of youth with type 1 diabetes.

Keyword:

reliability coefficient measurement error diagnostic accuracy Kendall's tau Bias

Author Community:

  • [ 1 ] [Wu, Mixia]Beijing Univ Technol, Coll Appl Sci, Beijing, Peoples R China
  • [ 2 ] [Zhang, Dianchen]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA
  • [ 3 ] [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA

Reprint Author's Address:

  • [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD USA;;[Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Biostat & Bioinformat Branch, 6710B Rockledge Dr,Room 3230, Bethesda, MD 20817 USA

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Source :

JOURNAL OF BIOPHARMACEUTICAL STATISTICS

ISSN: 1054-3406

Year: 2016

Issue: 6

Volume: 26

Page: 1111-1117

1 . 1 0 0

JCR@2022

ESI Discipline: PHARMACOLOGY & TOXICOLOGY;

ESI HC Threshold:169

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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