• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Wang, Gui-Hua (Wang, Gui-Hua.) | Liu, Yang (Liu, Yang.) | Wu, Xiao-Bing (Wu, Xiao-Bing.) | Lu, Ying (Lu, Ying.) | Liu, Jin (Liu, Jin.) (Scholars:金浏) | Qin, Ya-Ru (Qin, Ya-Ru.) | Li, Tong (Li, Tong.) | Duan, Hai-Feng (Duan, Hai-Feng.)

Indexed by:

Scopus SCIE PubMed

Abstract:

Background aims. Mesenchymal stromal cells (MSCs) possess the ability to repair brain injuries. Additionally, nimodipine is a neuroprotective agent that increases cerebral blood flow and may help with the homing of MSCs to the injury site. Here we investigate the effectiveness of a combined human umbilical cord derived MSCs and nimodipine therapy in radiation-induced brain injury (RIBI). Methods. Female mice received whole brain irradiation (WBI) and were treated with saline, nimodipine, hUC-MSCs, or hUC-MSCs combined with nimodipine. Body weight was measured weekly. An open field test for locomotor activity and a step-down avoidance test for learning and memory function were conducted at week 4 and week 12 post-WBI. The histological damage was evaluated by hematoxylin and eosin staining and glial fibrillary acidic protein immunohistochemistry. Quantitative polymerase chain reaction and Western blotting were used to detect apoptosis-related mediators (p53, Bax and Bcl-2). Results. In mice receiving the hUC-MSCs or the combined treatment, their body weight recovered, their locomotor and cognitive ability improved, and the percentage of necrotic neurons and astrocytes was reduced. The combined therapy was significantly (P < 0.05) more effective than hUC-MSCs alone; these mice showed decreased expression of pro-apoptotic indicators (p53, Bax) and increased expression of an anti-apoptotic indicator (Bcl-2), which may protect brain cells. Conclusions. We demonstrated that hUC-MSCs therapy helps recover body weight loss and behavior dysfunction in a mice model of RIBI. Moreover, the effectiveness of the combined hUC-MSCs and nimodipine therapy is due to apoptosis inhibition and enhancing homing of MSCs to the injured brain.

Keyword:

nimodipine radiation-induced brain injury mesenchymal stromal cells apoptosis

Author Community:

  • [ 1 ] [Wang, Gui-Hua]Xinxiang Med Univ, Affiliated Hosp 1, Dept Neurol, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China
  • [ 2 ] [Li, Tong]Xinxiang Med Univ, Affiliated Hosp 1, Dept Neurol, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China
  • [ 3 ] [Wang, Gui-Hua]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
  • [ 4 ] [Wu, Xiao-Bing]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
  • [ 5 ] [Liu, Jin]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
  • [ 6 ] [Qin, Ya-Ru]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
  • [ 7 ] [Duan, Hai-Feng]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
  • [ 8 ] [Liu, Yang]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China
  • [ 9 ] [Lu, Ying]307 Hosp Chinese Peoples Liberat Army, Beijing, Peoples R China

Reprint Author's Address:

  • [Li, Tong]Xinxiang Med Univ, Affiliated Hosp 1, Dept Neurol, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China;;[Duan, Hai-Feng]Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China

Show more details

Related Keywords:

Source :

CYTOTHERAPY

ISSN: 1465-3249

Year: 2016

Issue: 1

Volume: 18

Page: 53-64

4 . 5 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:238

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 28

SCOPUS Cited Count: 31

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 5

Online/Total:645/10560142
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.