Previous　neuroimaging　studies　suggested　structural　or　functional　brain　reorganizations　occurred　in　prelingually　deaf　subjects.　However,　little　is　known　about　the　reorganizations　of　brain　network　architectures　in　prelingually　deaf　adolescents.　The　present　study　aims　to　investigate　alterations　of　whole-brain　functional　network　using　resting-state　fMRI　and　graph　theory　analysis.　We　recruited　16　prelingually　deaf　adolescents　(10　similar　to　18　years)　and　16　normal　controls　matched　in　age　and　gender.　Brain　networks　were　constructed　from　mean　time　courses　of　90　regions.　Widely　distributed　network　was　observed　in　deaf　subjects,　with　increased　connectivity　between　the　limbic　system　and　regions　involved　in　visual　and　language　processing,　suggesting　reinforcement　of　the　processing　for　the　visual　and　verbal　information　in　deaf　adolescents.　Decreased　connectivity　was　detected　between　the　visual　regions　and　language　regions　possibly　due　to　inferior　reading　or　speaking　skills　in　deaf　subjects.　Using　graph　theory　analysis,　we　demonstrated　small-worldness　property　did　not　change　in　prelingually　deaf　adolescents　relative　to　normal　controls.　However,　compared　with　healthy　adolescents,　eight　regions　involved　in　visual,　language,　and　auditory　processing　were　identified　as　hubs　only　present　in　prelingually　deaf　adolescents.　These　findings　revealed　reorganization　of　brain　functional　networks　occurred　in　prelingually　deaf　adolescents　to　adapt　to　deficient　auditory　input.