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Abstract：
A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using a-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from a-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutannic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
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ACS NANO
ISSN： 1936-0851
Year： 2015
Issue： 11
Volume： 9
Page： 11455-11461
1 7 . 1 0 0
JCR@2022
ESI Discipline： CHEMISTRY;
ESI HC Threshold：253
JCR Journal Grade：1
CAS Journal Grade：1
Cited Count：
WoS CC Cited Count： 447
SCOPUS Cited Count： 494
ESI Highly Cited Papers on the List： 40 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 6
Affiliated Colleges：
