Metal-organic　frameworks　(MOFs)　have　recently　emerged　as　a　new　type　of　nanoporous　materials　with　tailorable　structures　and　functions.　Usually,　MOFs　have　uniform　pores　smaller　than　2　nm　in　size,　limiting　their　practical　applications　in　some　cases.　Although　a　few　approaches　have　been　adopted　to　prepare　MOFs　with　larger　pores,　it　is　still　challenging　to　synthesize　hierarchical-pore　MOFs　(H-MOFs)　with　high　structural　controllability　and　good　stability.　Here　we　demonstrate　a　facile　and　versatile　method,　an　in　situ　self-assembly　template　strategy　for　fabricating　stable　H-MOFs,　in　which　multi-scale　soluble　and/or　acid-sensitive　metal-organic　assembly　(MOA)　fragments　form　during　the　reactions　between　metal　ions　and　organic　ligands　(to　construct　MOFs),　and　act　as　removable　dynamic　chemical　templates.　This　general　strategy　was　successfully　used　to　prepare　various　H-MOFs　that　show　rich　porous　properties　and　potential　applications,　such　as　in　large　molecule　adsorption.　Notably,　the　mesopore　sizes　of　the　H-MOFs　can　be　tuned　by　varying　the　amount　of　templates.