This　study＇s　purpose　was　to　investigate　the　biomechanical　effects　of　varus　and　valgus　knee　deformities　in　different　degrees　on　the　acetabulum＇s　weight-bearing　dome.　We　collected　six　lower　extremity　specimens　from　three　fresh　adult　male　cadavers,　including　the　L5　vertebral　body,　pelvis,　bilateral　hips,　bilateral　knees　and　lower　leg　sections.　We　visually　examined　all　specimens　and　then　X-rayed　them　to　exclude　the　presence　of　hip　and　knee　pathology.　We　adjusted　the　tibiofemoral　angle　to　180　degrees　(knee　varus　at　10　degrees,　Group　A),　190　degrees　(knee　varus　at　20　degrees,　Group　B),　160　degrees　(knee　valgus　at　10　degrees,　Group　C)　and　150　degrees　(knee　valgus　at　20　degrees,　Group　D)　using　the　external　fixator,　respectively,　fixed　them,　respectively,　and　then　monitored　them　through　the　above　3D　laser　scanning　imager.　We　found　the　acetabulum＇s　weight-bearing　dome　area,　stress　and　stress　distribution　by　loading　and　coloring　on　the　pressure-sensitive　film.　We　measured　them　using　a　FPD-305　density　meter　and　FPD-306　pressure　converter.　We　compared　the　areas,　average　stresses　and　peak　stresses　of　the　acetabulum＇s　weight-bearing　dome　between　groups　B　and　D　and　group　A,　respectively.　The　differences　between　groups　B　and　D　had　no　significance.　Compared　to　group　A＇s　area,　average　stress　and　peak　stress,　the　areas　of　groups　C　and　E　decreased,　and　their　average　stresses　and　peak　stresses　increased　significantly.　The　differences　between　groups　B　and　C　and　groups　D　and　E　were　also　significant.　Due　to　different　degrees　of　knee　varus　and　valgus　angles,　the　areas　of　the　weight-bearing　acetabulum　dome,　average　stress　and　peak　stress　are　different.　The　knee　varus　and　valgus　at　20　degrees　were　statistically　significant,　which　may　be　the　key　pathogenesis　of　hip　arthritis.