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Author:

Zhu, Weimin (Zhu, Weimin.) | Huang, Jianghong (Huang, Jianghong.) | Lu, Wei (Lu, Wei.) | Sun, Qifeng (Sun, Qifeng.) | Peng, Liangquan (Peng, Liangquan.) | Fen, Wenzhe (Fen, Wenzhe.) | Li, Hao (Li, Hao.) | Ou, Yangkan (Ou, Yangkan.) | Liu, Haifeng (Liu, Haifeng.) | Wang, Daping (Wang, Daping.) | Zeng, Yanjun (Zeng, Yanjun.)

Indexed by:

EI Scopus SCIE

Abstract:

Objective: By in situ polymerization of poly-L-lactic acid (PLLA) and nano-hydroxyapatite (Nano-HA), and finding the best proportion of composite, so as to get ideal interface fixation material. Methods: According to a certain ratio (the mass fraction of Nano-HA, respectively, is 0%, 10%, 20%, 30% and 40%), composite PLLA and Nano-HA by in situ polymerization, and test the performance of this kind of new type of interface fixation such as, bending strength,compressive strength, elastic modulus, scanning electron microscopy (SEM) and degradation experiments in vitro. Then observe its mechanical properties, microstructure, the dispersion of Nano-HA in the PLLA and degradation rate of composite materials. Results: 1. Mechanical tests show that with the increase of Nano-HA content, the tensile strength decreases and the elastic modulus increases; with Nano-HA content of 20%, the bending strength of composite materials presents the peak value (156.8 MPa). 2. SEM scan shows the fracture surface of pure PLLA is relatively smooth; with Nano-HA content of 10%, the fracture surface shows a large number of dimples, and is obvious rough; with Nano-HA content of 20%, the fracture surface is uneven, forming a large number of dimples; with Nano-HA content of 30% or more, the fracture surface becomes more flat, and there are some small dimples. 3. Degradation experiments in vitro show the following: as the degradation time goes on, the pH values of degradation liquid is gradually reduced and the mechanical properties of composite materials also gradually have some decay. Conclusion: With Nano-HA content of 20%, the interface fixation material has a better mechanical properties and degradation properties. According to the best ratio, prepare Nano-HA/PLLA composite artificial materials with good performance.

Keyword:

in situ polymerization interface screw nano-hydroxyapatite poly-L-lactic acid

Author Community:

  • [ 1 ] [Zhu, Weimin]Guangzhou Med Univ, Dept Surg, Guangzhou, Guangdong, Peoples R China
  • [ 2 ] [Wang, Daping]Guangzhou Med Univ, Dept Surg, Guangzhou, Guangdong, Peoples R China
  • [ 3 ] [Zhu, Weimin]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 4 ] [Lu, Wei]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 5 ] [Sun, Qifeng]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 6 ] [Peng, Liangquan]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 7 ] [Fen, Wenzhe]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 8 ] [Li, Hao]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 9 ] [Ou, Yangkan]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 10 ] [Liu, Haifeng]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 11 ] [Wang, Daping]Shenzhen Second People Hosp, Dept Sports Med, Shenzhen 518000, Peoples R China
  • [ 12 ] [Zhu, Weimin]Shenzhen Tissue Engn Lab, Shenzhen, Peoples R China
  • [ 13 ] [Huang, Jianghong]Shenzhen Tissue Engn Lab, Shenzhen, Peoples R China
  • [ 14 ] [Wang, Daping]Shenzhen Tissue Engn Lab, Shenzhen, Peoples R China
  • [ 15 ] [Zeng, Yanjun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing, Peoples R China

Reprint Author's Address:

  • [Wang, Daping]Shenzhen Second People Hosp, Dept Sports Med, Sungang West Rd, Shenzhen 518000, Peoples R China

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Source :

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY

ISSN: 2169-1401

Year: 2014

Issue: 5

Volume: 42

Page: 331-335

5 . 8 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:285

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 11

SCOPUS Cited Count: 11

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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