Auto-thermal　reforming　(ATR)　is　an　effective　route　to　extract　hydrogen　from　both　water　and　acetic　acid　(HAc)　from　bio-oil.　With　addition　of　oxygen　into　ATR,　the　reaction　heat　can　be　balanced,　but　the　migration　of　oxygen　for　oxidation　of　carbonous　species　from　HAc　is　still　a　concern.　Here,　we　report　NiYxZr0.85-xOy　(x　=　0,　0.05,　0.1,　0.2,　0.4,　0.85)　catalysts　with　Y-Zr-O　solid　solution　as　support　for　hydrogen　production　via　ATR　of　HAc.　The　oxygen　vacancies　provided　by　Y-Zr-O　solid　solution　are　beneficial　to　activating　surface　oxygen　species　and　improve　oxygen　mobility　of　the　nickel　catalyst,　thus　the　oxygen　transfer　from　reactant　to　product　CO　and　CO2　was　enhanced.　On　the　other　hand,　Ni　nanoparticles,　the　active　metal,　are　highly　dispersed　on　the　Y-Zr-O　solid　solution　carrier.　Consequently,　the　NiY0.2Zr0.65O1.75　catalyst　exhibits　the　highest　activity　and　enhanced　stability:　the　acetic　acid　conversion　is　near　100　%　and　the　yield　of　hydrogen　reaches　3.0　mol-H-2/mol-HAc,　and　no　obviously　coking　is　found　after　the　reaction.