Polymer　flooding　technology　has　been　used　in　the　oilfield,　but　huge　amounts　of　polymer-flooding　wastewater　are　produced　with　oil　extraction.　Therefore,　the　treatment　and　recycle　of　this　wastewater　become　very　significant.　In　this　study,　the　membrane　technology　was　used　to　treat　synthetic　oilfield　polymer-flooding　wastewater　in　laboratory-scale　dead-end/cross-flow　test　unit　with　flat　polyvinylidene　fluoride　(PVDF)　membrane　(MW　100　kDa).　We　systematically　inspected　the　membrane　fouling　mechanism,　the　variety　of　total　fouling　resistance,　the　dominant　resistance,　and　the　filtration　proceeds　in　the　filtration　process.　The　orthogonal　method　and　multivariate　linear　regression　method　were　applied　to　analyze　the　influencing　degree　of　main　pollutants　concentration　which　contains　partially　hydrolyzed　polyacrylamide　(HPAM),　oil　and　suspended　solid　on　the　total　membrane　fouling　resistance.　According　to　a　comparison　of　the　average　rates　of　change　of　total　membrane　fouling　resistance　for　the　HPAM　concentration,　oil　concentration,　and　suspended　solid　(SS)　concentration　in　single　solute　solution,　double　solute　solution,　synthetic　oilfield　polymer-flooding　wastewater,　and　the　value　of　pH,　HPAM　can　decrease　the　average　rate　of　change　of　total　membrane　fouling　resistance　for　other　two　solutes　and　has　the　crucial　effect　on　the　total　membrane　fouling　resistance.　The　sequence　of　influence　degree　on　the　total　membrane　fouling　resistance　is　the　HPAM　concentration　＞　oil　concentration　＞　suspended　solid　concentration.　Moreover,　the　membrane　cleaning　effect　was　studied　by　using　SEM　images　and　the　pure　water　flux.