An　efficient　copper-catalyzed　method　has　been　developed　for　Sonogashira　couplings　of　aryl　halides　with　terminal　alkynes　in　water.　The　protocol　uses　inexpensive　CuBr　as　the　catalyst,　1,10-phenanthroline　as　the　ligand,　tetrabutylammonium　bromide　(TBAB)　as　the　phase-transfer　catalyst,　environmentally　friendly　water　as　the　solvent,　and　various　internal　alkynes　were　synthesized　in　good　to　excellent　yields.