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Author:

Zhang Yi-sen (Zhang Yi-sen.) | Yang Xin-jian (Yang Xin-jian.) | Wang Sheng-zhang (Wang Sheng-zhang.) | Qiao Ai-ke (Qiao Ai-ke.) (Scholars:乔爱科) | Chen Jia-liang (Chen Jia-liang.) | Zhang Kun-ya (Zhang Kun-ya.) | Liu Zhi-cheng (Liu Zhi-cheng.) | Zhao Yu-jing (Zhao Yu-jing.) | Zhang Ying (Zhang Ying.) | Luo Bin (Luo Bin.) | Li Chuan-hui (Li Chuan-hui.)

Indexed by:

Scopus SCIE

Abstract:

Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms. Methods Three idealized plexiglass aneurismal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD. Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac. Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting. Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization. Chin Med J 2010;123(15):1999-2003

Keyword:

hemodynamics computational fluid dynamics intracranial aneurysm stents

Author Community:

  • [ 1 ] [Zhang Yi-sen]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 2 ] [Yang Xin-jian]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 3 ] [Zhao Yu-jing]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 4 ] [Zhang Ying]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 5 ] [Luo Bin]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 6 ] [Li Chuan-hui]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China
  • [ 7 ] [Wang Sheng-zhang]Fudan Univ, Dept Mech & Engn Sci, Shanghai 200433, Peoples R China
  • [ 8 ] [Chen Jia-liang]Fudan Univ, Dept Mech & Engn Sci, Shanghai 200433, Peoples R China
  • [ 9 ] [Qiao Ai-ke]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100024, Peoples R China
  • [ 10 ] [Zhang Kun-ya]Capital Med Univ, Dept Biomed Engn, Beijing 100050, Peoples R China
  • [ 11 ] [Liu Zhi-cheng]Capital Med Univ, Dept Biomed Engn, Beijing 100050, Peoples R China

Reprint Author's Address:

  • [Yang Xin-jian]Capital Med Univ, Beijing Neurosurg Inst, Dept Intervent Neuroradiol, Beijing 100050, Peoples R China

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Source :

CHINESE MEDICAL JOURNAL

ISSN: 0366-6999

Year: 2010

Issue: 15

Volume: 123

Page: 1999-2003

6 . 1 0 0

JCR@2022

ESI Discipline: CLINICAL MEDICINE;

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 22

SCOPUS Cited Count: 26

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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