Self-centering　precast　segmental　bridge　columns　(SC-PSBCs)　have　been　intensively　investigated　in　the　past　decade　as　one　of　prefabricated　bridge　components　to　expedite　construction　and　improve　seismic　resilience.　However,　the　application　of　SC-PSBCs　is　limited　to　the　low　seismicity　areas　due　to　insufficient　knowledge　about　their　seismic　performance.　In　particular,　the　behavior　of　SC-PSBCs　is　not　clear　under　multi-directional　seismic　excitations.　In　order　to　investigate　the　effect　of　lateral　loading　directions　on　the　seismic　performance　of　SC-PSBCs,　five　1/10-scale　identical　SC-PSBC　specimens　with　rectangular　hollow　sections　were　designed　and　tested　under　lateral　cyclic　loading　and　a　constant　vertical　load.　Each　specimen　was　loaded　at　a　specific　angle　with　respect　to　the　weak　axis　of　the　column　section.　The　loading　angles　included　0,　30,　45,　60,　and　90　degrees.　The　seismic　performance　of　the　specimens　was　evaluated　and　discussed　using　the　test　results.　It　was　found　that　the　SC-PSBC　specimens　were　of　good　ductility,　and　the　favorable　self-centering　capacity　was　obtained　under　orthogonal　loading　directions.　Only　considering　the　orthogonal　loading　direction　in　the　design　of　SC-PSBCs　is　non-conservative　since　it　may　underestimate　the　local　damage　and　residual　displacement.　The　extent　of　prestress　loss　in　each　strand　was　very　sensitive　to　the　relative　distance　to　the　neutral　axis　depending　on　the　loading　directions.　The　equivalent　viscous　damping　ratios　of　SC-PSBCs　were　in　the　range　from　0.151　to　0.198　at　a　drift　ratio　of　4.0%.