LINGO-1　(leucine-rich　repeat　and　Ig　domain-containing,　Nogo　receptor-interacting　protein)　is　an　important　component　of　the　NgR　receptor　complex　involved　in　RhoA　activation　and　axon　regeneration.　The　authors　report　on　passive　immunization　with　LINGO-1　polyclonal　antiserum,　a　therapeutic　approach　to　overcome　NgR-mediated　growth　inhibition　after　spinal　cord　injury　(SCI).　The　intrathecally　administered　high-titer　rabbit-derived　antiserum　can　be　detected　around　the　injury　site　within　a　wide　time　window;　it　blocks　LINGO-1　in　vivo　with　high　molecular　specificity.　In　this　animal　model,　passive　immunization　with　LINGO-1　antiserum　significantly　decreased　RhoA　activation　and　increased　neuronal　survival.　Adult　rats　immunized　in　this　manner　show　recovery　of　certain　hindlimb　motor　functions　after　dorsal　hemisection　of　the　spinal　cord.　Thus,　passive　immunotherapy　with　LINGO-1　polyclonal　antiserum　may　represent　a　promising　repair　strategy　following　acute　SCI.　Copyright　(C)　2010　S.　Karger　AG,　Basel