Antibiotics,　especially　halogenated　antibiotics,　which　account　for　nearly　40%　of　the　total　antibiotics　in　China,　pose　great　environmental　risks;　however,　the　superior　stability　of　C-F　bond　and　low　concentrations　hinder　their　degradation,　indicating　the　need　for　developing　of　highly　efficient　treatment　technologies.　There　is　an　additional　concern　that　some　degradation　products　could　be　as　active/toxic　as　or　even　more　than　their　parent　compound.　The　stable　C-F　bond　can　be　relative　easily　cleaved　by　UV　light　irradiation,　which　could　come　from　sunlight.　Herein,　a　novel　UV-driven　electro-Fenton　catalytic　membrane　(UV-EFCM)　filtration　system　that　favors　resistance　elimination　and　efficient　degradation　of　low-concentration　antibiotics　is　proposed　for　the　first　time.　The　photoelectrochemical/electro-Fenton　(PEC/EF)　coupling　reaction　is　synchronously　conducted　in　a　sequential　filtration　system.　Almost　complete　degradation　and　high　mineralization　(78.4　+/-　9.1%)　of　florfenicol　were　achieved　at　a　concentration　of　as　low　as　14　mu　M　with　the　hydraulic　retention　time　of　0.98　h　during　the　UV-EFCM　filtration　system.　Complete　elimination　of　its　antibacterial　activity,　and　significant　defluorination　improvement　(56　+/-　3.6%)　compared　to　electro-Fenton　filtration　process　(11　+/-　5.3%)　were　achieved　due　to　the　prior　cleavage　of　the　stable　C-F　bond　with　antibiotic　potency　under　UV　light　pretreatment.　This　study　thus　proposes　a　novel　UV-EFCM　filtration　system,　which　couples　PEC　and　EF　with　a　potential　to　tackle　the　environmental　problems　associated　with　antibiotic　pollution.