Response　surface　methodology　(RSM)　was　applied　to　optimize　the　magnetic　coagulation　conditions　for　micro-polluted　river　water　treatment.　Based　on　single-factor　experiment,　Box-Behnken　central　composition　experiment　design　was　applied.　The　poly　aluminum　Chloride　(PAC),　magnetic　particle,　polyacrylamide　(PAM),　mixing　stirring　and　flocculating　stirring　revolving　speed　were　chosen　as　causal　factors.　RSM　was　employed　to　study　the　effects　of　these　factors　on　the　turbidity　removal　efficiency.　Base　on　the　target　value　(＞95%),　the　results　show　that　the　optimum　conditions　were　PAC　29.31　mgL(-1),　magnetic　particle　61.90mgL(-1),　PAM　0.48mgL(-1),　mixing　stirring　revolving　speed　288rpm,　flocculating　stirring　revolving　speed　6　rpm.　The　average　turbidity　removal　efficiency　in　three　validation　experiments　was　95.36%,　with　the　predicted　value　was　95.19%.　The　relative　error　between　the　measured　data　and　the　predicted　value　was　0.17%.　It　confirms　that　RSM　was　a　useful　tool　to　optimize　the　magnetic　coagulation　operating　conditions　for　micro-polluted　river　water　treatment.