Antibiotic　contamination　has　already　been　one　of　hazards　to　aquatic　environment　due　to　the　abuse　of　antibiotics.　Metal-organic　frameworks　(MOFs)　are　known　as　a　kind　of　promising　porous　material　for　solving　the　environmental　deterioration.　In　this　article,　the　physicochemical　and　electrochemical　properties　of　a　series　of　porous　copper　oxide　carbon　materials　(CuOx-C)　synthesized　by　carbonizing　Cu-BTC　were　compared.　Due　to　the　suitable　carbonization　temperature,　CuOx-C-550　N,　whose　geometric　structure　was　similar　to　Cu-BTC,　possessed　a　multiscale　pore　structure　containing　many　mesopores　and　partial　macropores　in　accordance　with　the　pore　size　distribution　curves.　More　copper/copper　oxides　were　introduced　toimproving　the　electrochemical　ability,　evidence　by　XRD,　XPS,　CV　and　EIS　characterization.　Moreover,　the　degradation　of　ceftazidime　(CAZ)　through　anodic　oxidation　was　discussed.　In　AO/CuOx-C-550　N　system,　the　effects　of　current,　solution　pH,　initial　CAZ　concentration　and　Na2SO4　concentration　were　analyzed.　CAZ　removal　rate　reached　100%　within　20　min　under　the　optimal　condition　and　a　good　electrocatalytic　ability　with　90%　CAZ　removal　after　20　runs　indicated　a　good　electrochemical　stability　of　CuOx-C-550　N.　Furthermore,　the　degradation　mechanism　and　pathway　of　CAZ　were　proposed.　The　Cu(II)/Cu(I)　oxidation-reduction　couples　on　the　anodic　surface　contribute　to　the　efficiently　selective　degradation　of　cephalosporins　for　CuOx-C-550　N.　Overall,　this　study　shows　a　good　method　to　design　and　prepare　a　new　MOF　derivative　for　the　remediation　of　aquatic　contamination.　©　2020　Elsevier　Ltd