Triclosan　(TCS)　is　an　emerging　contaminant　that　threatens　the　environment　and　human　health.　This　study　was　conducted　to　investigate　TCS　abatement　by　a　novel　electro-oxidation　(EO)　process,　which　used　a　Ti-based　nickel　and　antimony　doped　tin　oxide　(NATO/Ti)　anode　and　a　carbon　nanotubes　(CNTs)　doped　carbon/PTFE　(CNTs-C/PTFE)　gas　diffusion　electrode　(GDE)　for　oxygen　reduction　reaction　(ORR).　A　comparative　study　was　also　performed　for　TCS　degradation　by　using　a　traditional　EO　with　a　nickel　foam　cathode,　termed　as　HER-EO.　The　optimal　initial　TCS　concentration,　current　density　and　solution　pH　for　TCS　degradation　during　the　ORR-EO　and　HER-EO　were　investigated.　Results　showed　that　ORR-EO　removed　more　than　98%　of　TCS　in　10-60　min　under　the　concentration　of　5-50　mg/L.　The　TCS　degradation　followed　pseudo-first-order　kinetics　and　its　main　intermediates　were　observed　during　the　ORREO　and　HER-EO　using　liquid　chromatography　combined　mass　(LC-MS).　The　results　of　FED　analysis　and　toxicity　prediction　by　ECOSAR　software　showed　that　less　intermediates　accumulated　during　the　ORR-EO　and　the　residues　were　less　harmful.　The　ORR-EO　degradation　mechanism　for　TCS　was　attacking　on　the　ether　bond　and　the　benzene　ring　by　(OH)-O-center　dot.　This　novel　ORR-EO　process　exhibits　a　great　merit　in　the　field　of　emerging　contaminants　abatement.　(C)　2020　Elsevier　Ltd.　All　rights　reserved.