Background:　The　STM　CP-24　centrifugal　pump　is　a　newly　developed　centrifugal　pump　for　extracorporeal　membrane　oxygenation　equipment.　This　study　aimed　to　combine　hydraulic　experiments,　hemodynamic　numerical　simulations,　and　standard　in　vitro　hemolysis　experiments　to　investigate　the　comprehensive　performance　of　this　centrifugal　pump.　Methods:　In　vitro　experiments　were　first　done　to　obtain　the　pressure-flow　data　of　the　centrifugal　pump　in　its　working　range　to　evaluate　its　hydraulic　performance.　Next,　the　commonly　used　clinical　working　points　were　selected　as　boundary　conditions,　and　a　computational　fluid　dynamics　method　was　applied　to　evaluate　its　hemodynamic　performance.　The　blood　pressure　distribution,　blood　flow　fields,　and　high-wall-shear-stress　zones　in　the　centrifugal　pump　were　determined　as　indicators　for　hemodynamic　evaluation.　Finally,　standard　in　vitro　hemolysis　experiments　were　performed　to　test　the　blood　compatibility　of　this　centrifugal　pump　(n=3　blood　samples).　In　addition,　its　blood　compatibility　was　evaluated　in　the　form　of　the　normalized　index　of　hemolysis　(NIH).　Results:　The　pressure-flow　curve　of　the　centrifugal　pump　showed　that　the　head　pressure　and　flow　of　the　centrifugal　pump　showed　a　mostly　linear　relationship　within　the　whole　working　range.　When　the　rotation　speed　of　the　centrifugal　pump　was　5,500　rpm,　it　achieved　a　hydraulic　performance　of　550　mmHg　head　pressure　and　8　L/min　output　flow,　which　could　meet　the　clinical　needs　of　extracorporeal　membrane　oxygenation.　Analysis　of　computational　fluid　dynamics　data　indicated　that　the　centrifugal　pump　had　excellent　hemodynamic　performance:　even　distribution　of　blood　pressure　in　the　pump,　no　blood　flow　stagnation　zone　or　dead　zone　in　the　overall　flow　field,　and　secondary　flows　in　the　gap　between　the　rotor　and　the　volute　that　significantly　reduced　the　volume　of　the　low-blood-flow　zone　close　to　the　impeller.　There　was　no　obvious　high-shear-stress　zone　on　the　surface　of　the　volute　or　the　impeller,　which　will　effectively　reduce　the　risk　of　thrombosis.　In　vitro　hemolysis　experiments　indicated　that　the　centrifugal　pump　had　excellent　blood　biocompatibility,　with　a　NIH　=0.0125?0.0022　g/100　L.　Conclusions:　The　STM　CP-24　centrifugal　pump　has　excellent　hydraulic　performance,　a　reasonable　design　of　the　hemodynamic　structure　of　the　blood　pump,　and　excellent　blood　compatibility.　Therefore,　it　can　meet　Background:　The　STM　CP-24　centrifugal　pump　is　a　newly　developed　centrifugal　pump　for　extracorporeal　membrane　oxygenation　equipment.　This　study　aimed　to　combine　hydraulic　experiments,　hemodynamic　numerical　simulations,　and　standard　in　vitro　hemolysis　experiments　to　investigate　the　comprehensive　performance　of　this　centrifugal　pump.　Methods:　In　vitro　experiments　were　first　done　to　obtain　the　pressure-flow　data　of　the　centrifugal　pump　in　its　working　range　to　evaluate　its　hydraulic　performance.　Next,　the　commonly　used　clinical　working　points　were　selected　as　boundary　conditions,　and　a　computational　fluid　dynamics　method　was　applied　to　evaluate　its　hemodynamic　performance.　The　blood　pressure　distribution,　blood　flow　fields,　and　high-wall-shear-stress　zones　in　the　centrifugal　pump　were　determined　as　indicators　for　hemodynamic　evaluation.　Finally,　standard　in　vitro　hemolysis　experiments　were　performed　to　test　the　blood　compatibility　of　this　centrifugal　pump　(n=3　blood　samples).　In　addition,　its　blood　compatibility　was　evaluated　in　the　form　of　the　normalized　index　of　hemolysis　(NIH).　Results:　The　pressure-flow　curve　of　the　centrifugal　pump　showed　that　the　head　pressure　and　flow　of　the　centrifugal　pump　showed　a　mostly　linear　relationship　within　the　whole　working　range.　When　the　rotation　speed　of　the　centrifugal　pump　was　5,500　rpm,　it　achieved　a　hydraulic　performance　of　550　mmHg　head　pressure　and　8　L/min　output　flow,　which　could　meet　the　clinical　needs　of　extracorporeal　membrane　oxygenation.　Analysis　of　computational　fluid　dynamics　data　indicated　that　the　centrifugal　pump　had　excellent　hemodynamic　performance:　even　distribution　of　blood　pressure　in　the　pump,　no　blood　flow　stagnation　zone　or　dead　zone　in　the　overall　flow　field,　and　secondary　flows　in　the　gap　between　the　rotor　and　the　volute　that　significantly　reduced　the　volume　of　the　low-blood-flow　zone　close　to　the　impeller.　There　was　no　obvious　high-shear-stress　zone　on　the　surface　of　the　volute　or　the　impeller,　which　will　effectively　reduce　the　risk　of　thrombosis.　In　vitro　hemolysis　experiments　indicated　that　the　centrifugal　pump　had　excellent　blood　biocompatibility,　with　a　NIH　=0.0125　+/-　0.0022　g/100　L.　Conclusions:　The　STM　CP-24　centrifugal　pump　has　excellent　hydraulic　performance,　a　reasonable　design　of　the　hemodynamic　structure　of　the　blood　pump,　and　excellent　blood　compatibility.　Therefore,　it　can　meet　clinical　needs.