Rheumatoid　Arthritis　(RA)　is　a　chronic　autoimmune　disease,　which　mainly　causes　inflammation　of　the　synovial　joints　and　destruction　of　cartilage　and　bone　tissue.　At　present,　a　variety　of　clinical　drugs　have　been　applied　in　the　treatment　of　rheumatoid　arthritis.　With　the　development　of　nanotechnology,　more　and　more　nano-drugs　have　been　applied　in　the　treatment　of　rheumatoid　arthritis　due　to　the　unique　physical　and　chemical　properties　of　nanomaterials.　Treatment　of　RA　with　nanomaterials　can　improve　bioavailability　and　selectively　target　damaged　joint　tissue.　In　this　review,　we　summarized　the　progress　of　the　application　of　nanomaterials　in　the　treatment　of　rheumatoid　arthritis　and　also　proposed　challenges　faced　by　nanomaterials　in　the　treatment　of　rheumatoid　arthritis.